A5076661833- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Cellular transport and secretion
- Health disparities and outcomes
- Ubiquitin and proteasome pathways
- Mental Health and Patient Involvement
- Geriatric Care and Nursing Homes
- Sleep and related disorders
- Delphi Technique in Research
- Pancreatic function and diabetes
- Genetic Neurodegenerative Diseases
- Lipid Membrane Structure and Behavior
- Health and Medical Research Impacts
- Alzheimer's disease research and treatments
- Insect and Pesticide Research
- Ethics in Clinical Research
- Intergenerational Family Dynamics and Caregiving
- Ophthalmology and Visual Impairment Studies
- Heat shock proteins research
- Retinal Imaging and Analysis
- Cholinesterase and Neurodegenerative Diseases
- vaccines and immunoinformatics approaches
- Nicotinic Acetylcholine Receptors Study
- Prenatal Substance Exposure Effects
- Global Healthcare and Medical Tourism
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2024
Research Network (United States)
2024
National Institutes of Health
2024
Health Data Research UK
2021-2023
Alzheimer's Society
2012-2022
Imperial College London
2022
Epilepsy Research UK
2020
Newcastle University
2017
University of Cambridge
2004-2007
Little is known about how the proportions of dependency states have changed between generational cohorts older people. We aimed to estimate years lived in different at age 65 1991 and 2011, new projections future demand for care.In this population-based study, we compared two Cognitive Function Ageing Studies (CFAS I CFAS II) people (aged ≥65 years) who were permanently registered with a general practice three defined geographical areas (Cambridgeshire, Newcastle, Nottingham; UK). These...
Enabling people with dementia and carers to 'live well' the condition is a key United Kingdom policy objective. The aim of this project identify what helps live well or makes it difficult in context having caring for person dementia, understand 'living means from perspective carers.
Given considerable variation in diagnostic and therapeutic practice, there is a need for national guidance on the use of neuroimaging, fluid biomarkers, cognitive testing, follow-up terminology mild impairment (MCI). MCI heterogenous clinical syndrome reflecting change function deficits neuropsychological testing but relatively intact activities daily living. risk state further functional decline with 5-15% people developing dementia per year. However, ~50% remain stable at 5 years minority,...
Objective National and global dementia plans have focused on the research ambition to develop a cure or disease‐modifying therapy by 2025, with initial focus investment in drug discovery approaches. We set out complementary ambitions areas of prevention, diagnosis, intervention, care strategies for achieving them. Methods Alzheimer's Society facilitated taskforce leading UK clinicians researchers dementia, funders research, people carer representatives develop, using iterative consensus...
Background The prevalence of visual impairment (VI) and dementia increases with age these conditions may coexist, but few UK data exist on VI among people dementia. Objectives To measure the eye causing in to identify/describe reasons for underdetection or inappropriate management. Design Stage 1 – cross-sectional study. 2 qualitative research exploring participant, carer professional perspectives care. Setting 20 NHS sites six English regions. Participants 708 participants (aged 60–89...
This commentary discusses the implications of disease-modifying treatments for Alzheimer's disease which seem likely to appear in next few years and results from a meeting British experts neurodegenerative diseases Edinburgh. The availability such would help change public professional attitudes accelerate engagement with prodromal preclinical populations who might benefit them. However, this require an updated understanding disease, namely important distinction between dementia.Since are be...
We aimed to better understand what predicts the capability "live well" with dementia by identifying relative contribution of life domains associated subjective experience living well.We analyzed data from 1547 individuals mild-to-moderate in IDEAL cohort. generated a "living latent factor measures quality life, satisfaction and well-being. used multivariate modeling identify variables related well structural equation derive for 5 examine associations these well.All were individually well....
Objective To establish the prevalence and determinants of loneliness among people living with dementia. Methods Using data from baseline wave Improving experience Dementia Enhancing Active Life (IDEAL) cohort study, we examined predictors in 1547 mild‐to‐moderate Loneliness was assessed using six‐item De Jong Gierveld scale. Results About 30.1% dementia reported feeling moderately lonely 5.2% severely lonely. Depressive symptoms increased risk social isolation were associated both moderate...
Key points The focus on living well with dementia encourages a more positive and empowering approach right support can improve the experience of An holistic to assessing needs people identifying factors that impact their well‐being is essential Enabling live better requires broad encompasses both health social systems wider community
Introduction: Understanding key influences on outcomes for caregivers of people with dementia is hampered by inconsistent conceptualization and measurement limited evidence about the relative impact different variables. We aimed to address these issues. Methods: analyzed data from 1283 community-dwelling individuals mild-to-moderate in Improving experience Dementia Enhancing Active Life cohort study. generated a “living well” latent factor measures quality life, satisfaction well-being. used...
Loss of granule content during exocytosis requires the opening a fusion pore between secretory and plasma membrane. In variety cells, this has now been shown to subsequently close. However, it is still unclear how closure physiologically regulated contentious as relates loss. Here, we examine behavior zymogen in pancreatic acinar cells. By using entry high-molecular-weight dyes from extracellular solution into lumen, show that diameter 29–55 nm. We further by 5 min after fusion, many...
ABSTRACTBackground:40% of people with dementia have disturbed sleep but there are currently no known effective treatments. Studies hygiene and light therapy not been powered to indicate feasibility acceptability shown 40-50% retention. We tested the a six-session manualized evidence-based non-pharmacological therapy; Dementia RElAted Manual for Sleep; STrAtegies RelaTives (DREAMS-START) disturbance in dementia.We conducted parallel, two-armed, single-blind randomized trial 2:1 intervention:...
During exocytosis in the pancreatic acinar cell, zymogen granules fuse directly with apical plasma membrane and also that have themselves fused membrane. Together, these primary secondary fusion events constitute process of compound exocytosis. It has been suggested sequential nature is a consequence requirement for soluble N-ethylmaleimide-sensitive protein attachment receptors, such as syntaxin 2, to enter granule. We tested this possibility by determining location 2 unstimulated...
There is great interest in conducting clinical trials of disease-modifying therapies the prodromal (early, pre-dementia), asymptomatic stages Alzheimer's disease. Diagnostic biomarker tests offer a means identifying patients, but it unclear how potential participants feel about their use. Deciding whether to take part trial complex process which eligible must balance risks and discomforts against uncertain benefits. We sought explore views through qualitative research methods.Focus groups...
Abstract Introduction We examined 3‐month service use and costs of care for people with mild‐to‐moderate dementia in Great Britain. Methods analyzed Improving the experience Dementia Enhancing Active Life cohort study baseline data on paid care, out‐of‐pocket expenditure, unpaid from participants (N = 1547) their carers 1283). In regression analyses, we estimated per‐group mean diagnostic sociodemographic subgroups. Results Use services apart primary outpatient hospital was low. Unpaid...
Abstract The reproducibility of laboratory experiments is fundamental to the scientific process. There have been increasing reports regarding challenges in reproducing and translating preclinical animal models. In Alzheimer's disease related dementias, there similar growing interest from funding organizations, researchers, broader community set parameters around experimental design, statistical power, reporting requirements. A number efforts recent years attempted develop standard...