A5012069570- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Atrial Fibrillation Management and Outcomes
- Medication Adherence and Compliance
- COVID-19 and healthcare impacts
- Antibiotic Use and Resistance
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Health Sciences Research and Education
- Economic and Financial Impacts of Cancer
- Primary Care and Health Outcomes
- Venous Thromboembolism Diagnosis and Management
- Innovations in Medical Education
- Pharmaceutical Economics and Policy
- Endometrial and Cervical Cancer Treatments
- Data Quality and Management
- Prostate Cancer Treatment and Research
- Pneumonia and Respiratory Infections
- Cancer survivorship and care
- Diabetes Treatment and Management
- Lipoproteins and Cardiovascular Health
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac Arrhythmias and Treatments
- Long-Term Effects of COVID-19
University of Strathclyde
2017-2025
Public Health Scotland
2021-2025
Cardiovascular Institute Hospital
2024
University of Zurich
2023
University of Oxford
2023
Farr Institute
2018
Lund University
2016
Evangelisches Diakoniekrankenhaus
2008
Abbott Fund
2008
McGill University Health Centre
2007
There is currently no consensus on whether atrial fibrillation (AF) patients at low risk for stroke (one non-sex-related CHA2DS2-VASc point) should be treated with an oral anticoagulant.We conducted a multi-country cohort study in Sweden, Denmark, Norway, and Scotland. In total, 59 076 diagnosed AF were included. We assessed the rates of or major bleeding during treatment non-vitamin K antagonist anticoagulant (NOAC), vitamin (VKA), treatment, using inverse probability weighted (IPTW) Cox...
Abstract Aims To assess persistence and adherence to non-vitamin K antagonist oral anticoagulant (NOAC) treatment in patients with atrial fibrillation (AF) five Western European healthcare settings. Methods results We conducted a multi-country observational cohort study, including 559 445 AF initiating NOAC therapy from Stockholm (Sweden), Denmark, Scotland, Norway, Germany between 2011 2018. Patients were followed their first prescription until they switched vitamin antagonist, emigrated,...
Background The COVID-19 pandemic caused significant disruptions in healthcare services, with previous studies estimated that the early months of led to a substantial decline new prescriptions for hypercholesterolemia and hypertension. long-term recovery systems addressing these gaps remains uncertain. We aimed assess system Scotland regarding initiation treatments hypertension post-COVID-19 pandemic.
The aim of this study was to compare the clinical effectiveness and safety direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) routine practice.
To report the use of direct oral anticoagulants (DOACs) for stroke prevention in patients with atrial fibrillation Scotland and advocate standardisation drug utilisation research methods.Retrospective cohort study using linked administrative data. Patients included those a diagnosis (confirmed hospital) who received first prescription DOAC (dabigatran, rivaroxaban, or apixaban) from September 2011 to June 2014. Drug measures discontinuation, persistence, adherence.A total 5398 (mean CHA2 DS2...
To assess associations between statin intensity and adherence, persistence discontinuation of therapy in Scotland.Retrospective cohort study, using linked electronic health records covering a period from January 2009 to December 2016. The study included adult patients (≥18 years) newly initiating statins within Greater Glasgow Clyde, Scotland. Study outcomes comprised treatment, stratified by three exposure groups (high, moderate low intensity). Discontinuation were calculated the refill-gap...
Abstract Purpose New treatments are introduced into standard care based on clinical trial results. However, it is not clear if these benefits reflected in the broader population. This study analysed outcomes of patients with metastatic castration‐resistant prostate cancer, treated abiraterone and enzalutamide, within Scottish National Health Service. Methods Retrospective cohort using record linkage routinely collected healthcare data (study period: February 2012 to 2017). Overall survival...
<h3>Objective</h3> The Access, Watch and Reserve (AWaRe) list of antibiotics was developed by the WHO to support antibiotic stewardship programmes (ASP). Access group incorporates first-line options, while have higher resistance potential or toxicity, drugs should be used only for complex infections. ASP implementation has been challenged during COVID-19 pandemic. There is a knowledge gap regarding in-hospital prescribing patterns nationally pandemic, on characteristics hospitalised patients...
Objectives We undertook a national analysis to characterise and identify risk factors for acute respiratory infections (ARIs) resulting in hospitalisation during the winter period Scotland. Design A population-based retrospective cohort analysis. Setting Participants The study involved 5.4 million residents Main outcome measures Cox proportional hazard models were used estimate adjusted ratios (aHRs) 95% confidence intervals (CIs) association between ARI hospitalisation. Results Between 1...
Abstract Aim To evaluate the utilization and prescribing patterns of antidiabetic drugs (ADDs) for patients with type 2 diabetes mellitus (T2DM) at treatment initiation first intensification. Methods A retrospective cohort study was performed using linked routinely collected data T2DM who received ADDs between January 2010 December 2020 in Scotland. The were quantified frequency/percentages, absolute/relative change, trend tests. Results Overall, 145 909 new ADD users identified,...
We sought to investigate the incidence of severe COVID-19 outcomes after treatment with antivirals and neutralising monoclonal antibodies, estimate comparative effectiveness treatments in community-based individuals. conducted a retrospective cohort study investigating clinical hospitalisation, intensive care unit admission death, those treated antibodies for Scotland between December 2021 September 2022. compared effect various on risk outcomes, stratified by most prevalent sub-lineage at...
Little is known about the duration of antibiotic use in hospital settings. We evaluated therapy for four commonly prescribed antibiotics (amoxicillin, co-amoxiclav, doxycycline, and flucloxacillin) including assessment COVID-19 impact.A repeated, cross-sectional study using Hospital Electronic Prescribing Medicines Administration system (January/2019-March/2022). Monthly median therapy/duration categories was calculated, stratified by routes administration, age, sex. The impact assessed...
Abstract Objectives To estimate the impact of COVID-19 pandemic on cardiovascular disease (CVD) and CVD management using routinely collected medication data as a proxy. Design Descriptive interrupted time series analysis anonymised individual-level population-scale for 1.32 billion records dispensed medications across 15.8 million individuals in England, Scotland Wales. Setting Community with 100% coverage from Wales, plus primary care prescribed England (including 98% English general...
Background Cancer treatment is a key component of health care systems, and the increasing number cancer medicines expanding landscape. However, evidence impact on patients has been focused more chemotherapy toxicity symptom control less effect broadly patients’ lives. Evolving electronic patient-reported outcome measures (ePROMs) presents opportunity to secure early engagement clinicians in shaping collection quality-of-life metrics presenting these data better support patient-clinician...
To identify what matters to clinicians and patients when discussing cancer medicines' impact on health-related quality of life (HRQoL).A framework HRQoL domain/domain elements was developed, informed by analysis published patient reported outcome measures (PROMs), applicable prostate cancer. Using mixed methods (eDelphi, Nominal Group Technique questionnaire), attending clinics support groups were asked which domains/domain would be important them the medicines have their HRQoL.Twenty-one 71...
A 15-year-old girl was admitted in April 2004 owing to fatigue and loss of appetite. Her paediatrician had found elevated serum levels for alkaline phosphatase. The endoscopic retrograde cholangiography documented typical signs primary sclerosing cholangitis with involvement the small large ducts. liver biopsy revealed extensive septal portal fibrosis. No evidence inflammatory bowel disease present. She started on ursodeoxycholic acid therapy improved clinically. After 22 months she...