Objective: To assess the incidence, magnitude and factors associated with first episode of non-adherence for 12 months after antiretroviral prescription. Design: A prospective study HIV-infected patients receiving their prescription in public referral centers, Belo Horizonte, Brazil. Baseline assessment occurred at moment follow-up visits first, fourth seventh month, from May 2001 to 2003. Methods: Non-adherence was self-reported defined as intake less than 95% prescribed doses 3 days before...

OBJECTIVE: To evaluate indicators related to the rational use of medicines and its associated factors in Basic Health Units. METHOD: This is a cross-sectional study carried out representative sample Brazilian cities included Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos – Serviços, 2015 (PNAUM National Survey on Access, Use Promotion Rational Medicines Services, 2015). The data were collected by interviews with users, medicine dispensing professionals,...

Este é um estudo transversal, realizado no início de 2020, que teve como objetivo investigar a saúde mental (ansiedade, depressão e estresse) em estudantes universitários durante o estágio inicial da quarentena Brasil. Os participantes responderam uma pesquisa online sobre percepção COVID-19, quarentena, traços personalidade, ideação suicida (Escala Depressão, Ansiedade Estresse). dados foram analisados pelo algoritmo CART. Participaram 1957 (1418 mulheres, 72,30%) com idade entre 18 40 anos...

Follicular lymphoma (FL) is a common type of non-Hodgkin that incurable but often follows an indolent course. While survival improving thanks to advances in diagnosis, supportive care, and new therapies, understanding outcomes their impact on overall still limited. There are few studies FL Brazil, so this study aims evaluate the patient's profile, morbidity mortality treated by Brazilian national health service (SUS) risk factors associated with treatment failure. This nationwide 16 years...

This study analyzed breast cancer patients treated with trastuzumab in Brazil's unified health system (SUS) from 2008 to 2015. A non-concurrent cohort using SUS data applied propensity score matching reduce bias between and non-trastuzumab groups. Survival probabilities were estimated via Kaplan-Meier, subgroup analysis the log-rank test. Hazard ratios (HR) calculated Cox proportional hazards models. Among 20,852 patients, overall survival rate was 92%, 94% group 90% group. Younger, black...

This article presents the central concepts of multiple case study "Health Promotion in Primary Care" conducted by Nescon-UFMG 2005. Teams Family Health Program developed twelve health promotion experiences different Brazilian regions. After a conceptual revision and field research, was defined as process improving people independently any previous disease or injury, helping them to increase control over their health. We also concluded that an increased autonomy, understood capacity...

Background: Antidepressants are widely prescribed, and it is important to describe their use characteristics. We aimed estimate the prevalence of antidepressant identify associated factors in a cross-sectional study from middle-income country. Methods: Participants (n=8,803) National Survey on Access, Use, Promotion Rational Use Medicines Brazil, with representative sample, were asked about any medicines past 30 days. Through answers, we classified antidepressants users non-users. The...

Background: The Depression Anxiety Stress Scale‐21 (DASS‐21) has been widely studied in different populations as a brief screening tool to assess features of psychological distress. Because its multidimensionality, this scale is better addressed within complex system. Objective: Therefore, research aimed at investigating the psychometric properties using network analysis and other statistical evidence validity based on internal structure, since only two studies classical methods have...

The objective of this study was to evaluate the use drugs and factors associated with polypharmacy in patients diabetes mellitus (DM) Minas Gerais. Descriptive analysis logistic regression estimate association between socio-demographic clinical characteristics were performed. Of 2619 respondents, 56.5% polypharmacy. Drugs for DM, agent renin-angiotensin system, diuretics are most frequently used. Factors such as age, comorbidities increased access health services It observed high prevalence...

Background Multiple Sclerosis (MS) is a disease that appreciably impacts on the quality of life patients and associated with high expenditure. MS chronic multifactorial disease, characterized by inflammation, demyelination axonal loss. The Brazilian public health system provides pharmacological treatment as well hospital outpatient care for relapsing-remitting secondary progressive multiple sclerosis. However, we are not aware any previous publications assessing total direct medical costs in...

The new coronavirus pandemic has appreciably impacted morbidity and mortality, as well having an economic impact worldwide. New vaccines are a potential way forward to reduce transmission rates subsequent infection. In Brazil, being distributed via the public sector; however, in future, they will be available private market. Information about consumers' willingness pay (WTP) for hypothetical vaccine against SARS CoV-2 can help future price setting discussions.A cross-sectional study was...

Introduction and objectives: Statins have become an integral part of treatment to reduce cardiac events in patients with cardiovascular disease. However, their use within the public healthcare system Brazil is unknown. Consequently, we sought determine characterize statin primary delivered by health (SUS) evaluate associated patient factors improve future use.Methods: Cross-sectional study a national representative sample from five Brazilian regions, derived National Survey on Access, Use...

To assess associations between statin intensity and adherence, persistence discontinuation of therapy in Scotland.Retrospective cohort study, using linked electronic health records covering a period from January 2009 to December 2016. The study included adult patients (≥18 years) newly initiating statins within Greater Glasgow Clyde, Scotland. Study outcomes comprised treatment, stratified by three exposure groups (high, moderate low intensity). Discontinuation were calculated the refill-gap...

As most evidence for mental health impacts of the COVID-19 crisis is cross-sectional, present study aimed to analyze longitudinal development psychological suffering among 619 Brazilian adults by assessing outcomes and individual factors in two periods: a year before month after break pandemic. major findings, pandemic was directly explained previous-year suffering, conscientiousness, perceived stress, correlated with suicidal ideation. Pandemic stress distress, neuroticism, as well life...

<bold>Objetivo.</bold>Descrever a frequência, as características e os fatores que contribuem para o suicídio em povos indígenas brasileiros. <bold>Método.</bold>Foi realizada uma revisão sistemática da literatura partir das bases de dados PubMed, SciELO, PsycINFO LILACS. Foram incluídos estudos base populacional enfocassem populações no território brasileiro. <bold>Resultados.</bold>A busca identificou 111 artigos, dos quais nove preencheram critérios inclusão. Três foram realizados na...

Aim: To evaluate the persistence of biological (TNF inhibitor [anti-TNF]) and synthetic (conventional disease-modifying antirheumatic drugs [csDMARDs]) agents for psoriatic arthritis their associated factors. Methods: A historical cohort was developed. Persistence factors were evaluated at 6 12 months. Results: total 161 patients included. The anti-TNF treatment presented higher as compared with csDMARDs (83.4 vs 50.8%; p < 0.05) months (66.4 35.6%; 0.05). From anti-TNFs, adalimumab...

Background: Biological therapies have a significant economic and clinical burden but, in general, lose their effectiveness over time. This study evaluated the medication persistence costs associated to use of anti-TNF agents for psoriatic arthritis (PsA) treatment. Methods: A historical cohort composed individuals Brazil with PsA diagnosis was developed during period between 2010 2015. The difference among verified by log-rank test. predictors non-persistence were identified Cox regression....

Abstract Background Pharmaceutical Assistance (PA) is a dynamic and multidisciplinary process that aims to supply health systems, programs or services with quality medicines, enabling access care, in an efficient timely manner. The objective of the study was evaluate profile administrative processes for treatment PsA, identify time elapsed flow its associated factors. Methods A cross-sectional medication requests PsA carried out between November 2014 December 2016. Linear regression used...

Inappropriate use and increase of health care spending reinforce the need to extend our knowledge about quality medication use.To describe evaluate profile in a representative sample adult users primary services Unified Health System (SUS) Minas Gerais.Cross-sectional study, with 1,159 interviewees 104 municipalities 253 services. Data on sociodemographic characteristics, conditions medicines were collected, these variables stratified by age group. Univariate multivariate analyses, using...

Pharmaceutical services in Brazil provide access, supply, and rational use of drugs for all population an effort has been made to improve the quality these services. Biological are high-cost supplied that can inhibit disease progression life psoriatic arthritis (PsA) patients. However, some patients did not achieve therapeutic goals.To evaluate medication adherence persistence PsA treated with tumor necrosis factor inhibitors (anti-TNF) their associated factors.A prospective observational...

The bioethical debate in the world on who should pay for continuity of post-trials treatment patients that have medical indication remains obscure and introduces uncertainties to involved trials. post-trial was only incorporated 2000s by Helsinki Declaration. Universal Declaration Bioethics Human Rights, published 2006, points out may present a broader scope than just availability investigated medicine. In latest version this Declaration, 2013, it stated "prior start clinical trial, funders,...