A5042220933- Hormonal Regulation and Hypertension
- Atrial Fibrillation Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Adrenal Hormones and Disorders
- Pharmaceutical industry and healthcare
- Adrenal and Paraganglionic Tumors
- Pharmaceutical Economics and Policy
- Estrogen and related hormone effects
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Eicosanoids and Hypertension Pharmacology
- Antiplatelet Therapy and Cardiovascular Diseases
- Statistical Methods in Clinical Trials
- Rheumatoid Arthritis Research and Therapies
- Pharmaceutical Practices and Patient Outcomes
- Medication Adherence and Compliance
- Pharmacogenetics and Drug Metabolism
- Diabetes Treatment and Management
- Chronic Lymphocytic Leukemia Research
- Malaria Research and Control
- Autoimmune and Inflammatory Disorders Research
- Birth, Development, and Health
- Primary Care and Health Outcomes
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Healthcare Systems and Technology
University of Strathclyde
2014-2020
Health Data Research UK
2019
Imperial College London
2019
Farr Institute
2017-2018
University of Glasgow
2008-2017
University of Dundee
2013-2016
National Institute for Health Research
2016
William Harvey Research Institute
2012-2016
Queen Mary University of London
2012-2016
University of Manchester
2016
Data Resource Basics: The Prescribing Information System (PIS) covers the prescribed,dispensed and reimbursed prescriptions in community pharmacies from 5.3 million residents Scotland. Summary information is available 1993 at an individual level 2009 to present. Collected: raw data are generated by three sources: ePrescribed -generated GPs messages, eDispensed –generated messages Reimbursed scanned paper dispensed pharmacies. four main categories of collected are: (1) Patient-specific, (2)...
Dysregulation of aldosterone or cortisol production can predispose to hypertension, as seen in aldosterone-producing adenoma, a form primary aldosteronism. We investigated the role microRNA (miRNA) their production, with particular emphasis on CYP11B1 (11β-hydroxylase) and CYP11B2 (aldosterone synthase) genes, which produce enzymes responsible for final stages biosynthesis, respectively. Knockdown Dicer1, key enzyme miRNA maturation, significantly altered expression human adrenocortical cell...
There is an urgent need for health authorities across Europe to fully realize potential savings from increased use of generics sustain their healthcare systems. A variety strategies were used following the availability generic losartan, first angiotensin receptor blocker (ARB) be approved and marketed, enhance its prescribing vs. single-sourced drugs in class. Demand-side ranged 100% co-payment ARBs Denmark no specific measures. We hypothesized this heterogeneity approaches would provide...
Background Primary aldosteronism (PA), the most common secondary cause of hypertension, can be screened for using aldosterone/renin ratio. This ratio is raised in PA and its accuracy depends on ability to measure plasma renin at extremely low concentrations. Methods We compared two different procedures assessing renin. The conventional method, which measures activity (PRA), technically demanding laborious, Diasorin Liaison ® concentration (PRC), an automated immunoassay. Results from each...
The aim of this study was to compare the clinical effectiveness and safety direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) routine practice.
The loss of normal regulation corticosteroid secretion is important in the development cardiovascular disease. We previously showed that microRNAs regulate terminal stages biosynthesis. Here, we assess microRNA across whole pathway. Knockdown using Dicer1 siRNA H295R adrenocortical cells increased levels CYP11A1 , CYP21A1 and CYP17A1 mRNA cortisol, corticosterone, 11-deoxycorticosterone, 18-hydroxycorticosterone, aldosterone. Bioinformatic analysis genes involved biosynthesis or metabolism...
To report the use of direct oral anticoagulants (DOACs) for stroke prevention in patients with atrial fibrillation Scotland and advocate standardisation drug utilisation research methods.Retrospective cohort study using linked administrative data. Patients included those a diagnosis (confirmed hospital) who received first prescription DOAC (dabigatran, rivaroxaban, or apixaban) from September 2011 to June 2014. Drug measures discontinuation, persistence, adherence.A total 5398 (mean CHA2 DS2...
Context: The aldosterone to renin ratio (ARR) is a marker of excess, widely used screen for primary aldosteronism (PA). significance raised ARR in normotensive and hypertensive subjects the phenotypic familial factors affecting it are unclear. Objective: We estimated distribution heritability tested associations between blood pressure (BP) with 11 polymorphisms at CYP11B1/CYP11B2 locus. Design Setting: A total 1172 individuals from 248 Caucasian families ascertained via proband were...
The locus encompassing the corticosteroidogenic genes CYP11B2 and CYP11B1 is of potential importance in essential hypertension. We analyzed association polymorphisms at this with risk hypertension, using 2 white case-control collections for discovery (n=3340) confirmation (n=2929). Single-marker haplotype analyses were performed, Intron Conversion polymorphism showing strongest hypertension both cohorts combined analysis (odds ratio=1.16, P=8.54×10(-5)). ACA associated increased relative to...
Efficient generation of structured dose instructions that enable researchers to calculate drug exposure is central pharmacoepidemiology studies. Our aim was design and test an algorithm codify instructions, applied the NHS Scotland Prescribing Information System (PIS) records about 100 million prescriptions per annum.A natural language processing (NLP) developed enabled free-text be represented by three attributes - quantity, frequency qualifier specified three, two variables, respectively....
Dengue is a serious global health problem endemic in Brazil. Consequently, our aim was to measure the costs and disease burden of symptomatic dengue infections Brazil from perspective Brazilian Public Health System (SUS) between 2000 2015, using public system databases. Specific age group incidence estimates were used calculate disability-adjusted life years (DALYs) gain better understanding burden. Areas covered: SUS spent almost USD159 million USD10 treat severe dengue, respectively, 2015....
Clinical guidelines and public health authorities lack recommendations on scalable approaches to defining monitoring the occurrence severity of bleeding in populations prescribed antithrombotic therapy.
Genome-wide association studies implicate the CYP17A1 gene in human blood pressure regulation although causative polymorphisms are as yet unknown. We sought to identify common likely explain this association. sequenced locus 60 normotensive individuals and observed 24 previously identified single-nucleotide with minor allele frequency >0.05. From these, we selected, for further studies, 7 located ≤2 kb upstream of transcription start site. In vitro reporter assays 3 these (rs138009835,...
Abstract Purpose New treatments are introduced into standard care based on clinical trial results. However, it is not clear if these benefits reflected in the broader population. This study analysed outcomes of patients with metastatic castration‐resistant prostate cancer, treated abiraterone and enzalutamide, within Scottish National Health Service. Methods Retrospective cohort using record linkage routinely collected healthcare data (study period: February 2012 to 2017). Overall survival...
Objectives To understand patterns of subcutaneous (SC) biologics use over time in adults with inflammatory rheumatic musculoskeletal diseases receiving a homecare delivery service. Design Retrospective cohort. Setting Patients secondary care SC the largest Scottish Health Board. Participants A new bespoke cohort was created from routine data gathered as part health board Homecare Service Database. 18 years who received supply biologic January 2012 to May 2015 diagnosis for rheumatoid...
ABSTRACTObjectivesThere have been a number of key changes in the clinical definition and diagnostic threshold acute coronary syndromes last 10 years. We characterised temporal geographic incidence outcomes following Acute Coronary Syndrome (ACS: Unstable Angina (UA), Non ST-segment elevation myocardial infarction (NSTEMI) (STEMI)) between 2009 2013.
 Approach65,137 hospitals stays were identified involving ACS (ICD-10: I20.0, I21 I22) relating to 55,369 individuals through secondary...
ABSTRACTObjectivesBiologics are a class of medicines recommended by UK and international guidelines for treatment patients with rheumatoid arthritis (RA) who unresponsive, intolerant or have contraindications to conventional therapies. Biologics often supplied in the their home external healthcare providers commissioned National Health Service (NHS). Patient adherence persistence biologics has not been assessed within NHS Scotland.The aim this study was evaluate patterns subcutaneous...
Abstract Background Clinical guidelines and public health authorities lack recommendations on scalable approaches to defining monitoring the occurrence severity of bleeding in populations prescribed antithrombotic therapy. We aimed develop electronic record algorithms for different phenotypes, determine incidence, time trends prognosis patients with incident cardiac disorders indicated antiplatelet and/or vitamin K antagonist (VKA) Methods examined linked primary care, hospital admission...
Aldosterone, the mineralocorticoid hormone, plays an important role in blood regulation. Autonomous secretion of aldosterone is known as primary aldosteronism (PA), most common cause secondary hypertension. PA comprises a group heterogenous disorders which makes their classification and management challenging. With advent genomic era several germline somatic mutations have been identified that are involved pathogenesis aldosteronism. This article will review our current knowledge genetic...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)