A5015053477- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Mosquito-borne diseases and control
- Immune responses and vaccinations
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- vaccines and immunoinformatics approaches
- Geriatric Care and Nursing Homes
- Viral Infections and Immunology Research
- COVID-19 and Mental Health
- Biosensors and Analytical Detection
- Inflammasome and immune disorders
- COVID-19 diagnosis using AI
- COVID-19 and healthcare impacts
- Plant Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Liver Disease and Transplantation
- Clostridium difficile and Clostridium perfringens research
- CRISPR and Genetic Engineering
Portsmouth Hospitals NHS Trust
2017-2023
Imperial College London
2022
Quadram Institute
2022
Queen Alexandra Hospital
2020
John Wiley & Sons (United States)
2018
Linde (United States)
2018
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several nucleocapsid and ORF3a have arisen independently in multiple lineages result loss of recognition epitope-specific cells assessed IFN-γ cytotoxic killing assays. Complete responsiveness was seen due to Q213K the A∗01:01-restricted CD8+ epitope FTSDYYQLY207-215; P13L, P13S, P13T B∗27:05-restricted QRNAPRITF9-17; T362I P365S A∗03:01/A∗11:01-restricted KTFPPTEPK361-369. lines...
The Delta (B.1.617.2) variant was the predominant UK circulating SARS-CoV-2 strain between May and December 2021. How infection compares with previous variants is unknown. This prospective observational cohort study assessed symptomatic adults participating in app-based COVID Symptom Study who tested positive for from 26 to July 1, 2021 (Delta overwhelmingly variant), compared (1:1, age- sex-matched) individuals presenting 28, 2020 6, (Alpha (B.1.1.7) variant). We illness (symptoms,...
Introduction Throughout the global COVID-19 pandemic, nosocomial transmission has represented a major concern for healthcare settings and accounted many infections diagnosed within hospitals. As restrictions ease novel variants continue to spread, it is important uncover specific pathways by which outbreaks occur understand most suitable control strategies future. Methods In this investigation, SARS-CoV-2 genome sequences obtained from 694 workers 1,181 patients were analyzed at large acute...
Non-alcoholic fatty liver disease (NAFLD) affects approximately one in four adults of the general population, with an important minority cases at high risk developing cirrhosis. We evaluated utility a primary care NAFLD pathway incorporating specialist nurse-led clinic and two-step testing approach for advanced fibrosis.We performed retrospective evaluation prospectively collected demographic clinical data on all patients diagnosed intermediate fibrosis score seen our between 1 May 2014 30...
Robust assay development for SARS-CoV-2 serological testing requires assessment of asymptomatic and non-hospitalised individuals to determine if assays are sensitive mild antibody responses. Our study evaluated the performance characteristics two high-throughput IgG nucleocapsid (Abbott Architect Roche) The Binding Site (TBS) Anti-Spike IgG/A/M ELISA kit in samples from healthcare workers (HCWs). 252 were collected multi-site NHS trusts analysed serology. Assay was between these three...
Throughout the COVID-19 pandemic, valuable datasets have been collected on effects of virus SARS-CoV-2. In this study, we combined whole genome sequencing data with clinical (including outcomes, demographics, comorbidity, treatment information) for 929 patient cases seen at a large UK hospital Trust between March 2020 and May 2021. We identified associations acute physiological status three measures disease severity; admission to intensive care unit (ICU), requirement intubation, mortality....
Abstract Purpose SARS-CoV-2 serology testing is key for assessing seroprevalence and antibody response post-vaccination in immunocompromised patients. Evaluation of current serological assays have been performed on samples from severe COVID-19 hospitalised However, robust assay development requires assessment asymptomatic non-hospitalised individuals to determine if are sensitive detect waning mild responses. Our study evaluated the performance characteristics between two high-throughput IgG...
Introduction A key public health strategy is to increase screening for chronic viral hepatitis. However, rates of testing Hepatitis B and C in primary care remain low. Given that hepatitis may present with an abnormal ALT or hepatic steatosis on imaging, we hypothesised this population be a suitable target increased screening. In 2014, introduced integrated pathway the initial management suspected non-alcoholic fatty liver disease (NAFLD) which included at point entry. We examined impact...