A5103265468- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Black Holes and Theoretical Physics
- Astronomical Observations and Instrumentation
- Astronomy and Astrophysical Research
- Noncommutative and Quantum Gravity Theories
- Stellar, planetary, and galactic studies
- COVID-19 and healthcare impacts
- Health Systems, Economic Evaluations, Quality of Life
- Medical History and Innovations
- Respiratory Support and Mechanisms
- Quantum Electrodynamics and Casimir Effect
- Vascular anomalies and interventions
- COVID-19 diagnosis using AI
- SARS-CoV-2 and COVID-19 Research
- Astronomical and nuclear sciences
- Central Venous Catheters and Hemodialysis
- Relativity and Gravitational Theory
- Complement system in diseases
- COVID-19 epidemiological studies
- Forensic Entomology and Diptera Studies
- Astro and Planetary Science
- Vitamin C and Antioxidants Research
- Artificial Intelligence in Healthcare
University of Edinburgh
2021-2025
Roslin Institute
2021-2024
Institute of Population and Public Health
2021
Boehringer Ingelheim (United States)
2017
Glenfield Hospital
1995
Long COVID is a debilitating multisystem condition. The objective of this study was to estimate the prevalence long in adult population Scotland, and identify risk factors associated with its development.
Background The impact of COVID-19 on physical and mental health, employment following hospitalisation is poorly understood. Methods PHOSP-COVID a multi-centre, UK, observational study adults discharged from hospital with clinical diagnosis involving an assessment between two- seven-months later including detailed symptom, physiological biochemical testing. Multivariable logistic regression was performed for patient-perceived recovery age, sex, ethnicity, body mass index (BMI),...
Several countries restricted the administration of ChAdOx1 to older age groups in 2021 over safety concerns following case reports and observed versus expected analyses suggesting a possible association with cerebral venous sinus thrombosis (CVST). Large datasets are required precisely estimate between Coronavirus Disease 2019 (COVID-19) vaccination CVST due extreme rarity this event. We aimed accomplish by combining national data from England, Scotland, Wales.We created platforms consisting...
Background: Long COVID is a debilitating multisystem condition. To estimate prevalence and identify risk factors, we analysed routinely collected data from almost the entire adult population of Scotland.Methods: A cohort adults (≥18 years) resident in Scotland between March 1, 2020, October 20, 2022, was created by linking primary care, secondary laboratory testing prescribing. Four outcome measures were used to long COVID: clinical codes, free text care records, on sick notes, novel...
To the Editor:The BA.5 sub-lineage was first detected in South Africa January 2022. 1 It designated a variant of concern by UK Health and Security Agency on May 18, 2022, became dominant June 24, 2 There are few longitudinal population-based studies risks infection serious COVID-19 outcomes BA.5.A case control cross-sectional study Denmark found that associated with an increased risk hospitalisation compared to BA.2. 3 A test negative case-control England no evidence reduced vaccine...
Background The QCovid algorithm is a risk prediction tool that can be used to stratify individuals by of COVID-19 hospitalisation and mortality. Version 1 the was trained using data covering 10.5 million patients in England period 24 January 2020 30 April 2020. We carried out an external validation version Scotland. Methods established national platform individual level for population Scotland (5.4 residents). Primary care were linked reverse-transcription PCR (RT-PCR) virology testing,...
Summary Background There are currently no effective pharmacological or non-pharmacological interventions for Long-COVID. To identify potential therapeutic targets, we focussed on previously described four recovery clusters five months after hospital discharge, their underlying inflammatory profiles and relationship with clinical outcomes at one year. Methods PHOSP-COVID is a prospective longitudinal cohort study, recruiting adults hospitalised COVID-19 across the UK. Recovery was assessed...
Abstract PHOSP-COVID is a national UK multi-centre cohort study of patients who were hospitalised for COVID-19 and subsequently discharged. was established to investigate the medium- long-term sequelae severe requiring hospitalisation, understand underlying mechanisms these sequelae, evaluate effects treatments, serve as platform enable future studies, including clinical trials. Data collected covered wide range physical measures, biological samples, Patient Reported Outcome Measures...
Introduction The QCOVID algorithm is a risk prediction tool for infection and subsequent hospitalisation/death due to SARS-CoV-2. At the time of writing, it being used in important policy-making decisions by UK devolved governments combatting COVID-19 pandemic, including deliberations on shielding vaccine prioritisation. There are four statistical validations exercises currently planned algorithm, using data pertaining England, Northern Ireland, Scotland Wales, respectively. This paper...
Abstract Background In March 2022, a concerning rise in cases of unexplained pediatric hepatitis was reported multiple countries. Cases were defined as acute with serum transaminases >500 U/L (aspartate transaminase [AST] or alanine [ALT]) children aged 16 years younger. We explored simple federated data analytics method to search for evidence unreported using routinely held data. conducted pragmatic survey analyze changes the proportion hospitalized elevated AST ALT over time. addition,...
The gauge gravity action for general relativity in any dimension using a connection the Euclidean or Poincar\'e group and symmetry-breaking scalar field is written particularly simple matrix technique. A discrete version of variables on triangulated 3-manifold given it shown how, certain class triangulations three-sphere, quantum model this defines equivalent to Ponzano-Regge gravity.
The Hamiltonian analysis of the self-dual gauge gravity theory is carried out. resulting canonical structure equivalent to that gravity.
Background: The QCovid algorithm is a risk prediction tool for COVID-19 hospitalisation and mortality that can be used to stratify patients by into vulnerability groups . We carried out an external validation of the in Scotland.Methods: established national data platform using individual level population Scotland (5.4 million residents). Primary care were linked reverse-transcription polymerase chain reaction (RT-PCR) virology testing, data. assessed performance predicting deaths our dataset...
This thesis is broadly split into two parts. In the first part, simple state sum models for minimally coupled fermion and scalar fields are constructed on a $1$-manifold. The independent of triangulation give same result as continuum partition functions evaluated using zeta-function regularisation. Some implications more physical discussed. second gauge gravity action written particularly matrix technique. coupling to scalar, Yang-Mills reviewed, with some small additions. A over histories...
Abstract Background In patients with COVID-19 requiring supplemental oxygen, dexamethasone reduces acute severity and improves survival, but longer-term effects are unknown. We hypothesised that systemic corticosteroid administration during would be associated improved health-related quality of life (HRQoL) one year after discharge. Methods Adults admitted to hospital between February 2020 March 2021 for meeting current guideline recommendations treatment were included using two prospective...
Introduction: Venous neointimal hyperplasia (VNH) is a major cause of hemodialysis arteriovenous fistula (AVF) vascular access failure. CX3CR1 mediates macrophage infiltration into the vasculature. Mice were used which had been genetically engineered to knock in human gene. Hypothesis: The hypothesis be tested that increased gene expression results VNH formation associated with AVF. Methods: We 50 mice divided 2 groups: 1. antibody (30 mg/kg administered intraperitoneally two times per week)...
Abstract Optimising statistical power in early-stage trials and observational studies accelerates discovery improves the reliability of results. Ideally, intermediate outcomes should be continuously distributed lie on causal pathway between an intervention a definitive outcome such as mortality. In order to optimise for RECOVERY trial, we devised evaluated modification simple, pragmatic measure oxygenation function - S O 2 / F I (S/F) ratio. We demonstrate that, because ceiling effect...