A5089314912- Spectroscopy and Laser Applications
- Atmospheric Ozone and Climate
- Advanced Chemical Physics Studies
- Genetic Associations and Epidemiology
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atomic and Subatomic Physics Research
- Cardiovascular Function and Risk Factors
- Nutrition and Health in Aging
- Blood Pressure and Hypertension Studies
- Nutritional Studies and Diet
- Cardiovascular Health and Disease Prevention
- Molecular Spectroscopy and Structure
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Lanthanide and Transition Metal Complexes
- Obesity, Physical Activity, Diet
- Stellar, planetary, and galactic studies
- GDF15 and Related Biomarkers
- Meteorological Phenomena and Simulations
- Forest Management and Policy
- Chronic Disease Management Strategies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Dementia and Cognitive Impairment Research
- Atrial Fibrillation Management and Outcomes
University of Oxford
2009-2025
Medical Research Council
2018-2023
MRC Population Health Research Unit
2018
University of Washington
2018
Chinese Center For Disease Control and Prevention
2008-2012
Australian Astronomical Observatory
1998-2002
Australia Telescope National Facility
1998
University of Bristol
1993-1996
Leiden University
1992-1994
Leiden Observatory
1992-1993
We have measured the equivalent width of Hα emission line for 11 006 galaxies brighter than Mb=−19 (ΩΛ= 0.7, Ωm= 0.3, H0= 70 km s−1 Mpc−1) at 0.05 < z 0.1 in 2dF Galaxy Redshift Survey (2dFGRS), fields 17 known galaxy clusters. The limited redshift range ensures that our results are insensitive to aperture bias, and residuals from night sky lines. use these measurements trace μ*, star formation rate normalized L*, as a function distance cluster centre, local projected density. find...
Background— Low-density lipoprotein (LDL) cholesterol and high-density (HDL) are established risk factors for vascular disease, but particle concentrations may be stronger determinants of risk. Methods Results— Associations between events baseline fractions, apolipoproteins B A 1 , particles assessed by nuclear magnetic resonance were considered in the Heart Protection Study randomized trial simvastatin versus placebo (>5000 during 5.3 years follow-up among 20 000 participants). Major...
Background In China, there have been few large prospective studies of the associations body mass index (BMI) with overall and cause-specific mortality that simultaneously controlled for biases can be caused by pre-existing disease smoking. Methods Prospective cohort study 224 064 men, whom 40 700 died during follow-up between 1990–91 2006. Analyses restricted to 142 214 men aged 40–79 years at baseline no history and, further reduce bias from disease, least 5 subsequent follow-up, leaving 17...
Background: Genetic studies have shown lipoprotein(a) (Lp[a]) to be an important causal risk factor for coronary disease. Apolipoprotein(a) isoform size is the chief determinant of Lp(a) levels, but its impact on benefits therapies that lower remains unclear. Methods: HPS2-THRIVE (Heart Protection Study 2–Treatment HDL Reduce Incidence Vascular Events) a randomized trial niacin–laropiprant versus placebo background simvastatin therapy. Plasma levels at baseline and 1 year post-randomization...
Background and aims In the primary prevention setting, low-dose aspirin reduces major vascular events (MVEs) by approximately 11% but increases bleeding (MB) 40–50%, implying that net benefit will be most evident when MVE-to-MB ratio is >4. This study aimed to derive cross-validated risk scores for MB MVE use identify groups who may differing benefits from treatment. Methods 431 167 UK Biobank participants without known atherosclerotic cardiovascular disease at baseline were followed...
Cross sections and rate constants are presented for the rotational excitation of OH in collision with ortho para-H2, using a new ab initio interaction potential [Offer Van Hemert, J. Chem. Phys. 99, 3836 (1993)]. The cross given at number energies compared those calculated an earlier energy surface, available experimental results. A strong oscillatory behavior is found collisions ground state para-H2 which was not apparent calculations. very much reduced ortho-H2. Rate obtained by averaging...
A three-dimensional time-dependent quantum mechanical wavepacket method is used to calculate the state-to-state reaction probabilities at zero total angular momentum for Li + HF → LiF +H reaction. Reaction starting from several different initial vibrational–rotational states (v=0,j=0,1,2) and going all possible open channels are computed over a wide range of energies. single computation dynamics yields specific state reactants final The energy dependence shows broad background structure on...
AimsPlasma levels of apolipoprotein B (apoB), the main surface protein on LDL particles, and LDL-C, amount cholesterol in those are closely correlated and, considered separately, positive risk factors. Plasma A1, HDL HDL-C, also with each other negative The interdependence these four factors is unclear.
Statins reduce LDL cholesterol (LDL-C) and the risk of vascular events, but it remains uncertain whether there is clinically relevant genetic variation in their efficacy. This study 18 705 individuals aims to identify variants related lipid response simvastatin assess impact on response. A genome-wide LDL-C apolipoprotein B (ApoB) 40 mg daily was performed 3895 participants Heart Protection Study, nine strongest associations were tested 14 810 additional participants. Selected candidate...
Aspirin is widely used in cardiovascular disease prevention but also associated with an increased risk of bleeding. The net effect aspirin on dementia and cognitive impairment uncertain.
Alzheimer's disease (AD) risk is increased in carriers of the apolipoprotein E (APOE) ε4 allele and decreased ε2 compared with ε3ε3 genotype. The aim this study was to determine whether: APOE genotype affects brain grey (GM) or white matter (WM) structure; if differences exist, age when they become apparent whether there are differential effects by sex. We used cross-sectional magnetic resonance imaging data from ~43,000 (28,494 after pre-processing) British cognitively healthy participants...
The results of time-dependent quantum mechanical calculations on the photodissociation initially nonrotating HOCl and DOCl molecules are presented. Two processes, 1 1A″←X̃ 1A′ 2 1A′←X̃ 1A′, considered. dynamics treated in a two dimensional model with fixed O–H distance dissociation process is followed rotating body-fixed frame total angular momentum J′=1. spectra product rotational distributions resulting from originating number different vibrational states presented over continuous range...
Despite previous investigations, substantial uncertainty remains about the relation between body mass index (BMI) and stroke, especially in populations with a relatively low BMI but high stroke rate.A nationally representative prospective study of mortality included 212,000 Chinese men 40 to 79 years old without known cardiovascular disease 1990 1991 who were followed up for 10 years. Standardized hazard ratios calculated by baseline systolic blood pressure (SBP) BMI.Mean SBP 124 mm Hg 21.7...
Statins are widely used to prevent cardiovascular events, but little is known about the impact of different risk factors for statin-related myopathy or their relevance reports other types muscle symptom.
Abstract Background Chronological age is the strongest risk factor for most chronic diseases. Developing a biomarker-based and understanding its important contributing biomarkers may shed light on effects of later-life health inform opportunities disease prevention. Methods A subpopulation 141 254 individuals healthy at baseline were studied, from among 480 019 UK Biobank participants aged 40–70 recruited in 2006–2010, followed up 6–12 years via linked death secondary care records. Principal...
With the advent of very large redshift surveys tens to hundreds thousands galaxies, reliable techniques for automatically determining galaxy redshifts are becoming increasingly important. The most common technique currently in use is cross-correlation a galactic spectrum with set templates. This series papers presents new method based on principal component analysis. generalizes approach by replacing individual templates simultaneous linear combination orthogonal effectively eliminates...
Background Taller adult height is associated with lower risks of ischemic heart disease in mendelian randomization (MR) studies, but little known about the causal relevance for different subtypes stroke. The present study examined Methods and findings Height-associated genetic variants (up to 2,337) from previous genome-wide association studies (GWASs) were used construct instruments ancestral populations. Two-sample MR approaches examine associations genetically determined stroke its...
Reactive scattering probabilities are computed over a wide range of collision energies for model system based on the Li+HF→LiF+H reaction using both grid time-dependent and time-independent quantum mechanical methods. The computations carried out fixed Li–F–H angle which is chosen to be that at barrier chemical lowest. calculated this display many sharp features as function energy ascribed resonances. calculations have been very dense grid, thus permitting detailed comparison between methods...
Background Increased body mass index (BMI) is known to be related ischaemic heart disease (IHD) in populations where many are overweight (BMI ≥ 25 kg/m2) or obese 30). Substantial uncertainty remains, however, about the relationship between BMI and IHD with lower levels.
In warm and dense interstellar clouds, the amount of ortho-H2 is comparable to that para-H2. Yet most models excitation molecules have considered only We present here calculations rate coefficients for rotational OH by both para- in their ground states within coupled-states formulation. The coupled results are shown reproduce satisfactorily more accurate close-coupling calculations. importance inclusion (j = 1) explored using statistical equilibrium models. general, presence reduces...