A5019476173- Nutrition, Genetics, and Disease
- Metabolomics and Mass Spectrometry Studies
- Nutritional Studies and Diet
- Diet and metabolism studies
- Statistical Methods and Inference
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Lipid metabolism and disorders
- Metabolism, Diabetes, and Cancer
- Advanced Statistical Methods and Models
- Diet, Metabolism, and Disease
- Genetic Associations and Epidemiology
- Consumer Attitudes and Food Labeling
- Data Analysis with R
- Adipose Tissue and Metabolism
- Gene Regulatory Network Analysis
- Gene expression and cancer classification
- Advanced Causal Inference Techniques
- Atherosclerosis and Cardiovascular Diseases
- Nuclear Receptors and Signaling
- Congenital heart defects research
- Lysosomal Storage Disorders Research
- Fatty Acid Research and Health
- Probabilistic and Robust Engineering Design
- Sparse and Compressive Sensing Techniques
Max Rubner Institut
2016-2025
University of Lübeck
2014-2017
German Centre for Cardiovascular Research
2017
University of Stuttgart
2012-2016
Institute for Integrative and Experimental Genomics
2014
Ezetimibe lowers plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting the activity Niemann-Pick C1-like 1 (NPC1L1) protein. However, whether such inhibition reduces risk coronary heart disease is not known. Human mutations that inactivate a gene encoding drug target can mimic action an inhibitory and thus be used to infer potential effects drug.We sequenced exons NPC1L1 in 7364 patients with 14,728 controls without who were European, African, or South Asian ancestry. We...
Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD show pleiotropy; that is, they are also other diseases or traits. This study sought to systematically test if genetic variants for non-CAD diseases/traits associate and undertake a comprehensive analysis the extent pleiotropy all loci. In discovery analyses involving 42,335 cases 78,240 control subjects we tested 29,383 common (minor allele frequency >5%) single...
Scope Knowledge on the influence of current diet trimethylamine‐N‐oxide (TMAO) levels in humans is still inconsistent. Thus, we aimed to investigate associations with urine and plasma TMAO determine effect different foods variation. Methods results concentrations 297 healthy individuals were assessed using 1 H‐NMR spectroscopy for 24 h collection spot urine, LC‐MS plasma. Of 35 food groups, those a correlation ρ >|0.15| or further investigated multivariate linear regression models showing...
In clinical nutrition, it is regularly observed that individuals respond differently to a dietary treatment. Personalized nutrition aims consider such variability in response by delivering personalized nutritional recommendations. Ideally, the optimal treatment for each individual will be selected and then dispensed according specific individual’s characteristics. The aim of this paper discuss apply existing statistical methods, which can adequately used context nutrition. We estimation...
In addition to their role in lipid absorption, bile acids (BAs) are also known for several relevant (endocrine) activities including contributing the regulation of energy homeostasis and some non-communicable diseases (NCDs). Furthermore, moderately elevated unconjugated bilirubin levels, as observed Gilbert’s syndrome (GS), may protect against NCDs. We therefore hypothesized that BA profile GS subjects differs from normo-bilirubinemic individuals. To test this, we performed a human...
Abstract Purified diets (PD) increase standardization and repeatability in rodent studies but lead to differences the phenotype of animals compared grain-based “chow” diets. PD contain less fiber are often devoid soluble fiber, which can impact gut health. Thus, aim present study was modify AIN93G by addition promote more natural development as seen with chow One hundred twenty male C57BL/6J mice were fed over 12 weeks either a diet, or one three modified increased content different ratios...
Although sugars and sugar derivatives are an important class of metabolites involved in many physiologic processes, there is limited knowledge on their occurrence pattern biofluids.Our aim was to obtain a comprehensive urinary profile healthy participants demonstrate the wide applicability usefulness this profiling approach for nutritional as well clinical studies.In cross-sectional KarMeN study, 24-h urine samples 301 unrestricted diet, assessed via recall, were analyzed by newly developed...
Scope Diabetes is thought to primarily represent a disturbance of carbohydrate metabolism; however, population studies employing metabolomics have mainly identified plasma amino acids and lipids, or their products, as biomarkers. In this pilot study, the aim analyze wide spectrum sugar compounds in fasting state during an oral glucose tolerance test (OGTT) healthy, prediabetic, type 2 diabetic volunteers. Methods results The three volunteer groups underwent standard OGTT. Plasma samples...
Inflammatory diseases, specifically rheumatoid arthritis (RA), are assumed to increase the risk of coronary artery disease (CAD). More recently, multiple single-nucleotide polymorphisms (SNP) associated with RA were identified. If causal mechanisms affecting risks and CAD overlapping, alleles for might also CAD.Sixty-one SNP associating in genome-wide significant analyses tested association CARDIoGRAM (Coronary ARtery DIsease Genome wide Replication Meta-analysis), a metaanalysis including...
In this paper, we consider first an estimator of the residual variance treated by Evans [(2005), 'Estimating Variance Multiplicative Noise', in 18th International Conference on Noise and Fluctuations, ICNF, AIP Proceedings, 780, pp. 99–102], Jones [(2008), 'Non-Parametric Estimation Residual Moments Covariance', Proceedings Royal Society A: Mathematical, Physical Engineering Sciences, 464, 2831–2846] Liitiäinen, Corona, Lendasse 'On Nonparametric Estimation', Neural Processing Letters, 28,...
Introduction: Endurance exercise alters whole-body as well skeletal muscle metabolism and physiology, leading to improvements in performance health. However, biological mechanisms underlying the body's adaptations different endurance protocols are not entirely understood. Methods: We applied a multi-platform metabolomics approach identify urinary metabolites associated metabolic pathways that distinguish acute response two interventions at distinct intensities. In our randomized crossover...
There are many examples in clinical nutrition with individuals responding differently to a dietary intervention. Here, personalized nutritional recommendations could be targeted, tailoring interventions address plurality response. For this, we reconsidered two randomized controlled trials investigating whether different supplementation doses of cholecalciferol resulted an increased serum 25(OH)D concentration. Three statistical methods were applied order identify participants who would enjoy...
Personalized nutrition aims to exploit heterogeneity. One reason for heterogeneity may be the presence of one or more subgroups that respond better a dietary intervention than observed average in entire population considered. However, designing studies solely with intention carry out subgroup analyses is challenging as unknown. In addition, anticipated effects are rarely known advance. This study investigates usefulness methodology where principled post hoc investigations used. By means both...
Abstract Introduction In metabolomics, the investigation of associations between metabolome and one trait interest is a key research question. However, statistical analyses such are often challenging. Statistical tools enabling resilient verification clear presentation therefore highly desired. Objectives Our aim to provide contribution for analysis metabolomics data, offering widely applicable open-source workflow, which considers intrinsic complexity data. Methods We combined selected R...