A5034894320- Genomic variations and chromosomal abnormalities
- Systemic Lupus Erythematosus Research
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Bacteriophages and microbial interactions
- Genetic Mapping and Diversity in Plants and Animals
- Venomous Animal Envenomation and Studies
- Biopolymer Synthesis and Applications
- Cancer Research and Treatments
- Medical Imaging and Pathology Studies
- Phagocytosis and Immune Regulation
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- E-commerce and Technology Innovations
- Genomics, phytochemicals, and oxidative stress
- Genomics and Rare Diseases
- Neuroscience and Neuropharmacology Research
- Galectins and Cancer Biology
- Biochemical and Structural Characterization
- Plant pathogens and resistance mechanisms
- Cholesterol and Lipid Metabolism
- Circular RNAs in diseases
- Lipid metabolism and disorders
Affiliated Hospital of Youjiang Medical University for Nationalities
2020-2025
Xuzhou Medical College
2020-2024
Nanjing Drum Tower Hospital
2024
Children's Hospital of Fudan University
2023
Suizhou Central Hospital
2023
Tianjin University
2020-2022
University of Jinan
2018-2020
Beijing Anzhen Hospital
2020
Capital Medical University
2010-2020
Fujian Provincial Hospital
2018
Agricultural practices could affect bacterial diversity and community structure by altering soil physical chemical properties. Straw returning tillage are widely used in agriculture, however, the effects of these agricultural on microbiomes still unclear. In present study, we compared 18 communities with different straw treatment combinations. The V3-V4 regions 16S ribosomal RNA were amplified analyzed high-throughput sequencing technology. results showed that consistently dominated...
Maize (Zea mays mays) oil is a rich source of polyunsaturated fatty acids (FAs) and energy, making it valuable resource for human food, animal feed, bio-energy. Although this trait has been studied via conventional genome-wide association study (GWAS), the single nucleotide polymorphism (SNP)-trait associations generated by GWAS may miss underlying when traits are based on many genes, each with small effects that can be overshadowed genetic background environmental variation. Detecting these...
A novel conotoxin, κ-conotoxin (κ-BtX), has been purified and characterized from the venom of a worm-hunting cone snail, Conus betulinus. The toxin, with four disulfide bonds, shares no sequence homology any other conotoxins. Based on partial amino acid sequence, its cDNA was cloned sequenced. deduced consists 26-residue putative signal peptide, 31-residue mature 13-residue extra peptide at C terminus. is cleaved off by proteinase post-processing. All three Glu residues are γ-carboxylated,...
The spatial distribution of proteome at subcellular levels provides clues for protein functions, thus is important to human biology and medicine. Imaging-based methods are one the most approaches predicting location. Although deep neural networks have shown impressive performance in a number imaging tasks, its application localization has not been sufficiently explored. In this study, we developed imaging-based approach localize proteins levels. Based on image features extracted from...
Abstract Long noncoding RNAs play an important role in several pathogenic processes diabetic nephropathy, but the relationship with epithelial-mesenchymal transition DN is unclear. Herein, we found that KIFAP3-5:1 expression was significantly down-regulated plasma samples, db/db mouse kidney tissues and high glucose treated renal tubular epithelial cells compared to normal healthy samples untreated cells. Overexpression of improved fibrosis mice rescued cultured The silence will exacerbate...
Tumor necrosis factor-alpha (TNF-α) is a potent proinflammatory cytokine that inhibits osteoblast differentiation while stimulating osteoclast and bone resorption. TNF-α activates MAP kinase pathway leading to inhibition of osterix (Osx) expression. also induces the expression E3 ubiquitin ligase protein Smurf1 Smurf2 promotes degradation Runx2, another key transcription factor regulating formation. We showed previously overexpression glucocorticoid (GC)-induced leucine zipper (GILZ)...
Abstract Background Increasing evidence has indicated that circular RNAs (circRNAs) play a role in various diseases. However, the influence of circRNAs nephritis remains unknown. Methods Microarray analysis and RT-qPCR were used to detect expression circRNA. Type I IFN administrated RMC HEK293 cells establish cell model. CCK-8, MTT assay, flow cytometry assess proliferation, viability, apoptosis cells. Bioinformatics dual luciferase reporter assay interaction circ_0007059, miRNA-1278, SHP-1....
Four peptide inhibitors of small-conductance Ca(2+)-activated, apamin-sensitive K(+) channels (SK(Ca)) have been isolated from the venom Chinese scorpion Buthus martensi, named BmP01, BmP02, BmP03, and BmP05, respectively [Romi-Lebrun, R. (1997) Eur. J. Biochem. 245, 457-464]. Among them BmP05 with 31 amino acid residues has intensively studied due to its most potent toxicity. To investigate structure-function relationship wild type seven mutants (their C-termini unamidated) were...
Abstract Martentoxin, a novel K + ‐channel‐specific peptide has been purified and characterized from the venom of East‐Asian scorpion ( Buthus martensi Karsch). The whole cDNA precursor sequence suggested that martentoxin was composed 37 residues with unique compared other neurotoxins. genomic DNA showed an additional intron situated unexpectedly in 5′ UTR region, besides one located close to C‐terminal signal peptide. patch‐clamp recording found at applied dose 100 n m could strongly block...
Objective: The study aimed to investigate the effects of quercetin on Aquaporin 1 (AQP1) translocation in high glucose condition and made an attempt clarify underlying mechanisms provide new ideas for treatment diabetic cataract (DC). Methods: human lens epithelial line SRA01/04 cells were divided into groups mentioned below: normal glucose, with a specific time (0 h, 2 4 8 12 24 h), plus phosphoinositide 3-kinase (PI3K) inhibitor LY294002, mammalian target rapamycin (mTOR) rapamycin,...
Constitutive or excessive activation of Toll-like receptor (TLR) signaling pathway can disrupt the body's immune tolerance to autoantigen, thus promoting development autoimmune disease. However, expression profile TLR in peripheral blood neutrophils pathogenesis microscopic polyangiitis (MPA) remains unclear. Thus, improved understanding pathobiology this disease may aid therapeutic targets for patients with MPA. In present study, we assessed pathway-related genes PCR array analysis was...
Summary Traditional genetic studies focus on identifying variants associated with the mean difference in a quantitative trait. Because also influence phenotypic variation via heterogeneity, we conducted variance‐heterogeneity genome‐wide association study to examine contribution of variance heterogeneity oil‐related traits. We identified 79 unique variance‐controlling single nucleotide polymorphisms (vSNPs) from sequences 77 candidate genes for 21 traits using Levene test ( P < 1.0 × 10...
Fractalkine (FKN) is a chemokine with several roles, including chemotaxis; adhesion; and immune damage, which also participates in cell inflammation apoptosis responds to the pathogenesis of autoimmune diseases. Given involvement regulatory T cells (Treg) diseases, this study investigated mechanism FKN renal injury Treg via p38 mitogen-activated protein kinase (p38MAPK) signaling pathway lupus-prone mice. Lupus was induced BALB/c female mice by injection pristane, followed isolation CD4
Objective: This study was to analyze the association of lipid parameters with insulin resistance Chinese elderly population in different glycemic status. Methods: Data were from China National Chronic Diseases and Nutrition Survey (2015). A total 15 535 participants aged 60 above who had completed survey questionnaire, physical examination, fasting blood biochemistry measurements included this study. According American Diabetes Association (2010) criteria, divided into normal glucose...