A5082359162- Management of metastatic bone disease
- Global Cancer Incidence and Screening
- Smoking Behavior and Cessation
- Spine and Intervertebral Disc Pathology
- Economic and Financial Impacts of Cancer
- Advanced Radiotherapy Techniques
- Spinal Fractures and Fixation Techniques
- Radiopharmaceutical Chemistry and Applications
- Healthcare Policy and Management
- Brain Metastases and Treatment
- Health disparities and outcomes
- Family Support in Illness
- Colorectal and Anal Carcinomas
- Advances in Oncology and Radiotherapy
- T-cell and Retrovirus Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Oral and Maxillofacial Pathology
- Insect and Arachnid Ecology and Behavior
- Boron Compounds in Chemistry
- Viral-associated cancers and disorders
- Biosimilars and Bioanalytical Methods
- Colorectal Cancer Surgical Treatments
- Behavioral Health and Interventions
- Sexual Assault and Victimization Studies
Stanford University
2022-2025
Stanford Medicine
2024-2025
University of California, San Diego
2019-2022
Kaiser Permanente
2016-2019
Emory University
2016-2017
Vanderbilt University
2016
Tobacco smoking is a major cause of chronic disease worldwide. Smoking may induce cellular and molecular changes including epigenetic modification, with both short-term long-term modification patterns that contribute to phenotypic expression diseases. Recent epigenome-wide association studies (EWAS) have identified dozens smoking-related DNA methylation (DNAm) sites. However, the X chromosomal DNAm sites been largely overlooked due lack an analytical framework for dealing sex-dimorphic...
Objectives: Smokers on chronic opioid therapy (COT) for noncancer pain use prescription opioids at higher dosages and are increased risk misuse dependence relative to nonsmokers. The current study aims assess whether smoking is associated with problems concerns COT from the perspective of patient. Materials Methods: In a large sample (N=972) adult patients prescribed pain, we examined sex-specific associations between status patient perceptions using regression analyses, adjusting...
Abstract Background For patients with spine metastases, stereotactic radiosurgery (SRS) provides excellent local control and pain response. Despite increasing use of this treatment modality, there is no consensus on the optimal dose fractionation SRS for efficacy toxicity. We have initiated a single-center phase III randomized trial that compares two regimens similar biological equivalent (BED) to determine isolated effect control. Methods Patients one three cervical, thoracic, or lumbar...
Objectives: To examine rates of smoking and tobacco treatment utilization by insurance coverage status (Medicaid, commercial, exchange) among newly enrolled patients in the post Affordable Care Act (ACA) era. Methods: We examined new members who Kaiser Permanente Northern California through Medicaid, exchange, or nonexchange commercial plans (N=122,298) first 6 months 2014 following ACA implementation. compared these groups on prevalence tested whether smokers each group differed...
Disparities in prostate cancer-specific mortality (PCSM) between African American and non-Hispanic White (White) patients have been attributed to biological systemic factors. We evaluated drivers of these disparities the Surveillance, Epidemiology, End Results (SEER) national registry an equal-access system, Veterans Health Administration (VHA).We identified diagnosed with cancer 2004 2015 SEER (n = 311 691) VHA 90 749). analyzed association race metastatic disease at presentation using...
Sexual assault (SA) is alarmingly common and associated with higher prevalence of psychiatric medical conditions. However, many prior studies are limited to cross-sectional designs. Health care systems electronic health records provide unique longitudinal data examine whether SA changes in utilization.The sample included 1350 Kaiser Permanente Northern California adult female patients a diagnosis from 2009 2015 4050 without diagnosis, matched on age, facility, continuous enrollment during...
Background Although treatment with checkpoint blockade is now accepted as standard of care for cutaneous melanoma, few studies have investigated its role in sinonasal melanoma (SNM). We aimed to evaluate whether immunotherapy was associated improved survival SNM and compare the effect metastatic melanoma. Methods This a cohort study patients included United States National Cancer Database who had been diagnosed or between 2012 2015 complete information regarding status. The primary outcome...
ABSTRACT: Task partitioning in eusocial animals is most likely an evolutionary adaptation that optimizes the efficiency of colony to grow and reproduce. It was investigated indirect task two castes sizes; this involves which material transported not transferred directly from one individual another, but where it dropped by ant be picked up another. In separate approaches, confirmed previous results pertaining leaf caching activities among Atta colombica with involving dropping sexdens...
Objectives: We examined the impact of Affordable Care Act–mandated elimination tobacco cessation pharmacotherapy (TCP) copayments on patient use TCP, overall and by income. Methods: Electronic health record data captured any combination (eg, nicotine gum plus patch) TCP among adult smokers newly enrolled in Kaiser Permanente Northern California (KPNC). KPNC eliminated 2015. included current first 6 months 2014 (before copayment elimination, N=16,199) or 2015 (after N=16,469). Multivariable...
Background Apolipoprotein D (ApoD) has been proposed as a predictor of breast cancer recurrence among estrogen receptor-positive (ER+), tamoxifen-treated patients. Methods We conducted population-based case-control study nested in population 11,251 women aged 35–69 years at diagnosis with Stage I–III between 1985 and 2001 on Denmark's Jutland Peninsula registered the Danish Breast Cancer Cooperative Group. identified 541 recurrent or contralateral cancers cases ER+ disease treated tamoxifen...
The Affordable Care Act (ACA) promised to narrow smoking disparities by expanding access healthcare and mandating comprehensive coverage for tobacco treatment starting in 2014. We examined whether two years after ACA implementation receiving clinician advice quit smokers' knowledge use of resources remained. conducted telephone interviews 2016 with a stratified random sample self-reported smokers newly enrolled the Kaiser Permanente Northern California's (KPNC) integrated delivery system...
Abstract Treatment paradigms for esophageal cancer are evolving and there is a growing need prognostic predictive biomarkers to guide clinical decision making. Perioperative chemotherapy has emerged as standard of care adenocarcinoma (EAC), yet some patients with an elevated local recurrence risk or poor tolerance intensified may benefit from neoadjuvant therapy including radiation. Biomarkers predicting treatment response radiation, chemotherapy, immunotherapy in other gastrointestinal...
Abstract Background: For patients with spine metastases, stereotactic radiosurgery (SRS) provides excellent local control and pain response. Despite increasing use of this treatment modality, there is no consensus on the optimal dose fractionation SRS for efficacy toxicity. We have initiated a phase III randomized trial that compares two regimens similar biological equivalent (BED) to determine isolated effect control. Methods: Patients one three cervical, thoracic, or lumbar metastases...