A5069005996- Ubiquitin and proteasome pathways
- Asthma and respiratory diseases
- RNA modifications and cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- VLSI and FPGA Design Techniques
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Odor and Emission Control Technologies
- Muscle Physiology and Disorders
- Lung Cancer Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Electronic Packaging and Soldering Technologies
- 3D IC and TSV technologies
- Circular RNAs in diseases
- Indoor Air Quality and Microbial Exposure
- Inhalation and Respiratory Drug Delivery
- Cardiovascular Function and Risk Factors
- Toxin Mechanisms and Immunotoxins
- Prostate Cancer Treatment and Research
- Pulmonary Hypertension Research and Treatments
- Peptidase Inhibition and Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- Immunotherapy and Immune Responses
Shanghai University of Traditional Chinese Medicine
2020-2023
The First Affiliated Hospital, Sun Yat-sen University
2021-2022
Zhongshan Hospital
2021-2022
Fudan University
2021-2022
Sun Yat-sen University
2015-2022
Jiangnan University
2022
China Electronics Technology Group Corporation
2020
Benzo(a)pyrene (BaP) is a ubiquitous air pollutants, and BaP exposure leads to risk of respiratory diseases. The oversecretion airway mucus high expression mucin 5AC (MUC5AC) are associated with common disorders caused by pollution. We aimed investigate the effect on MUC5AC expression, especially mechanisms which induces gene expression. human epithelial cell NCI-H292 was used test effects in vitro. mRNA protein were assessed real-time quantitative PCR, immunochemistry, western blotting. A...
Pulmonary rehabilitation is a crucial part of the nonpharmacological treatment stable chronic obstructive pulmonary disease (COPD), but management remains problematic. WeChat could serve as useful tool in patient management. Baduanjin popular exercise China that usually applied rehabilitation, which has been confirmed to be effective improving lung function and life quality.This study aimed explore efficiency COPD patients.A total 200 patients from respiratory department Putuo Hospital...
Skeletal muscle wasting is a clinically remarkable phenotypic feature of pulmonary arterial hypertension (PAH) that increases the risk mortality. Growth differentiation factor 11 (GDF11), centrally involved in PAH pathogenesis, has an inhibitory effect on skeletal growth other conditions. However, whether GDF11 pathogenesis remains unknown. We showed serum levels patients were increased following PAH. MCT-treated model accompanied by increase circulating and local catabolic markers (Fbx32,...
Abstract Background Asthma is a chronic airway inflammatory disease characterized by inflammation, mucus hypersecretion, hyper-reactivity. Sanzi Yangqin Decoction (SZYQD) widely prescribed for asthma treatment. Its anti-asthma activities have been reported in animal model, but the exact mechanism and targets of SZYQD treatment not fully elucidated. Methods A network pharmacological approach was used to predict active components, targets, signalling pathways asthma, including potential target...
Benzo(a)pyrene (BaP), an environmental pollutant, is present in high concentrations urban smog and cigarette smoke has been reported to promote mucin 5AC (MUC5AC) expression. Epithelium-derived inflammatory cytokines are considered important modulator of mucus oversecretion MUC5AC overexpression. Here, we investigated whether the effect BaP on overexpression was associated with cytokine autocrine activity vivo vitro.In vivo, BALB/c mice were treated ovalbumin (OVA) presence or absence BaP....
Background: Polygonum cuspidatum is a Chinese medicine commonly used to treat phlegm-heat asthma. However, its anti-asthmatic active ingredients and mechanism are still unknown. The aim of this study was predict the pathways further explore potential molecular in asthma by using network pharmacology. Methods: their targets related were seeked out with TCM systematic pharmacology analysis platform (TCMSP), ingredient-target constructed. GeneCards, DrugBank OMIM databases collect screen...
BACKGROUND:Loss of the epithelial barrier is characterized by a reduction in E-cadherin expression and hallmark asthma. Qi-xian decoction (QXT) Chinese medicinal formula that has been used to effectively treat This study aimed investigate effect QXT on human lung 16HBE cells ovalbumin-challenged mice explore underlying molecular mechanism. MATERIAL AND METHODS:Ovalbumin (OVA)-induced were as model Real-time PCR Western blotting utilized examine mRNA protein levels. Lung tissue reactive...
In this paper, the thermal stress problem in a novel chip embedded integration package is analyzed by finite element method. A can improve system level. kind of package, cavity silicon substrate, benzocyclobutene (BCB) filled gap space between and substrate. As expansion coefficients three parts (BCB\substrate\chip) are different, internal will occur package. The research focuses on effect characteristic size stress. Through simulation parametric design structure size, we obtain detail cloud...
<sec> <title>BACKGROUND</title> Pulmonary rehabilitation is a crucial part of the nonpharmacological treatment stable chronic obstructive pulmonary disease (COPD), but management remains problematic. WeChat could serve as useful tool in patient management. Baduanjin popular exercise China that usually applied rehabilitation, which has been confirmed to be effective improving lung function and life quality. </sec> <title>OBJECTIVE</title> This study aimed explore efficiency COPD patients....
Prostate cancer (PCa) ranks as the 2nd most common cause of death in men [1]. Radical prostatectomy or radiation therapy was considered traditional for localized prostate but not with metastatic stage. Although current mainstay PCa included surveillance PSA doubling time, androgen deprivation, targeting PI3K/AKT signaling axis, DNA damage repair, immune checkpoint, etc, currently identified biomarkers were robustly validated prognostication direct therapy, therefore, exploring novel...