A5062314391- Atmospheric chemistry and aerosols
- Air Quality and Health Impacts
- 3D Surveying and Cultural Heritage
- 3D Shape Modeling and Analysis
- Atmospheric and Environmental Gas Dynamics
- Vehicle emissions and performance
- Plant Molecular Biology Research
- Remote Sensing and LiDAR Applications
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- Ferroptosis and cancer prognosis
- Advanced Neural Network Applications
- RNA modifications and cancer
- Mathematics Education and Teaching Techniques
- Industrial Gas Emission Control
- Plant biochemistry and biosynthesis
- Single-cell and spatial transcriptomics
- Digital Imaging for Blood Diseases
- Plant Stress Responses and Tolerance
- Vehicle License Plate Recognition
- vaccines and immunoinformatics approaches
- Imbalanced Data Classification Techniques
State Key Laboratory of Pollution Control and Resource Reuse
2018-2024
Nanjing University
2021-2024
Tsinghua University
2022-2024
Inner Mongolia University
2023-2024
University of Sheffield
2024
Shanghai Normal University
2023
Zhejiang University
2019-2023
Wenzhou University
2023
Hangzhou DAC Biotech (China)
2023
Shandong Normal University
2023
The fat mass and obesity-associated enzyme (FTO) can catalyze the demethylation of N6-methyladenosine (m6A) residues in mRNA, regulates cellular level m6A modification, plays a critical role human obesity cancers. Herein, we develop single-quantum-dot (QD)-based fluorescence resonance energy transfer (FRET) sensor for identification specific FTO demethylase inhibitors. FTO-mediated induce cleavage demethylated DNA to generate biotinylated fragments, which may function as capture probes...
Abstract Abundant emissions have made China as one of the hotpots atmospheric reactive nitrogen (Nr) deposition over world. Here we conducted multi‐year simulation and explored trend interannual variations (IAVs) China's Nr for different forms (wet dry) species (oxidized reduced nitrogen, OXN RDN) during 2008–2017. Sensitivity analysis scenarios were applied to evaluate roles anthropogenic meteorological conditions on changing deposition. The annual mean was simulated at 15.7 ± 0.9 kg N ha...
Abstract. Due to the rapid development of industrialization and a substantial economy, China has become one global hotspots nitrogen (N) sulfur (S) deposition following Europe USA. Here, we developed dataset with full coverage N S from 2005 2020, multiple statistical models that combine ground-level observations, chemistry transport simulations, satellite-derived vertical columns, meteorological geographic variables. Based on newly random forest method, multi-year averages dry oxidized...
Rab14 is a member of RAS oncogene family, and its dysfunction has been reported to be involved in various types human cancer. However, expression function were still unclear gastric The aim this study was investigate the mechanism cancer cell lines. Quantitative real-time PCR (qRT-PCR) performed 17 adenocarcinoma tissues 4 lines detect Rab14. 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT), colony formation flow cytometry assays employed determine proliferative ability,...
Abstract Prostate cancer (PCa), the second leading cause of death in American men, is a relatively slow-growing malignancy with multiple early treatment options. Yet, significant number low-risk PCa patients are over-diagnosed and over-treated long-term quality life effects. Further, there ever increasing evidence metastasis higher mortality when hormone-sensitive or castration-resistant tumors treated indistinctively. Hence, critical need to discover clinically-relevant actionable...
T-cell receptor (TCR) detection can examine the extent of immune responses. Therefore, article analyzed characteristic data glioma obtained by DNA-based TCR high-throughput sequencing, to predict disease with fewer biomarkers and higher accuracy. We downloaded online six TCR-related diversity indices establish a multidimensional classification system. By comparing actual presence 602 correlated sequences, we two-dimensional datasets. Multiple methods were utilized for both datasets accuracy...
Salt tolerance is an important mechanism by which plants can adapt to a saline environment. To understand the process of salt tolerance, we performed global analyses mRNA alternative polyadenylation (APA), regulatory during eukaryotic gene expression, in Arabidopsis thaliana and its halophytic relative Eutrema salsugineum with regard their responses stress. Analyses showed that while APA occurs commonly both Eutrema, possesses fewer genes than (47% vs. 54%). However, proportion was...
Immobilization of enzyme could offer the biocatalyst with increased stability and important recoverability, which plays a vital role in enzyme's industrial applications. In this study, we present new strategy to build an intelligent carrier by coating titania nanoparticles thermoresponsive epoxy-functionalized polymers. Zero-valent copper-mediated living radical polymerization (Cu(0)-LRP) was utilized herein copolymerize N-isopropylacrylamide (NIPAM) glycidyl acrylate (GA) directly from...
Recent supervised point cloud upsampling methods are re-stricted by the size of training data and limited in terms covering all object shapes. Besides challenges faced due to acquisition, networks also struggle gener-alize on unseen records. In this paper, we present an internal approach at a holistic level referred as "Zero-Shot" Point Cloud Upsampling (ZSPU). Our is agnostic relies solely infor-mation provided particular without patching both self-training testing phases. This...
Stomata control gas exchange and water transpiration are one of the most important physiological apparatuses in higher plants. The regulation stomatal aperture is closely coordinated with photosynthesis, nutrient uptake, plant growth, development, so on. With advances scanning electron microscopy (SEM), high-resolution images stomata cell surfaces can be obtained from detached tissues. However, this method does not allow for rapid analysis dynamic variation situ under nondestructive...
MicroRNAs (miRNAs) have been well studied in human carcinogenesis and cancer progression. Our previous study showed the down-regulation of miR-338-3p expression gastric (GC). However, reasons this dysregulation remain largely unclear.Bisulfite sequence analysis was performed to explore methylation status promoter region miR-338-3p. Cell wound-healing transwell assays were examine capacity cell migration interaction. A dual-luciferase reporter used validate bioinformatics-predicted target...
Previous studies have shown that news events are relevant to stock price movements. We propose a novel multi-category driven trends prediction model, which uses the historical data of China's A-share market and stock-related listed companies as training set. extract several categories related investment, including performance pre-release event, executive increasing or decreasing shareholdings dividends employee option plan etc. Both SVM models neural networks used with event features....
The chaperonin 60 (Cpn60) protein is of great importance to plants due its involvement in modulating the folding numerous chloroplast polypeptides. In chloroplasts, Cpn60 differentiated into two subunit types—Cpn60α and Cpn60β rice genome encodes three α β plastid subunits. However, functions family members were poorly understood. order investigate molecular mechanism OsCpn60β1, we attempted disrupt OsCpn60β1 gene by CRISPR/Cas9-mediated targeted mutagenesis this study. We succeeded...
Studies over the past decade have generated a wealth of molecular data that can be leveraged to better understand cancer risk, progression, and outcomes. However, understanding progression risk differentiating long- short-term survivors cannot achieved by analyzing from single modality due heterogeneity disease. Using scientifically developed tested deep-learning approach leverages aggregate information collected multiple repositories with modalities (e.g., mRNA, DNA Methylation, miRNA)...
Abstract With the continuous development of information technology and running speed computers, informatization has led to generation increasingly more medical data. Solving unmet needs such as employing constantly developing artificial intelligence data providing support for industry is a hot research topic. Cytomegalovirus (CMV) kind virus that exists widely in nature with strict species specificity, infection rate among Chinese adults than 95%. Therefore, detection CMV great importance...
We develop a bidirectional isothermal amplification strategy for the sensitive detection of transcription factors in cancer cells.
The metal-polyphenol network has been widely employed in the field of nanodrugs delivery due to its pH-responsiveness.
In the real scene of 3D object detection, point cloud collected for a single is incomplete, resulting in misalignment classification and regression features uncertainty boundaries. Existing works pay little attention to caused by incompleteness clouds. To address this issue, we propose Feature Decoupling Uncertainty Estimation single-stage detector named FDUE-Net. First, design Classification-Regression Attention module extract shared low-level high-level decoupling paradigm, generating...