A5018655486- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- T-cell and Retrovirus Studies
- Salivary Gland Tumors Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Vascular Tumors and Angiosarcomas
- CAR-T cell therapy research
- Cutaneous lymphoproliferative disorders research
- Acute Myeloid Leukemia Research
- Virus-based gene therapy research
- Islanding Detection in Power Systems
- Retinal Diseases and Treatments
- Gastrointestinal Tumor Research and Treatment
- Platelet Disorders and Treatments
- Higher Education Learning Practices
- Inflammatory Biomarkers in Disease Prognosis
- Adolescent and Pediatric Healthcare
- Glycosylation and Glycoproteins Research
- MRI in cancer diagnosis
- Ocular Oncology and Treatments
- Cancer Immunotherapy and Biomarkers
- Vascular Malformations and Hemangiomas
Capital Medical University
2007-2024
Beijing Tongren Hospital
2007-2024
Beijing Children’s Hospital
2019
Beijing Ditan Hospital
2017
Background: Asparaginase (ASP) is the cornerstone drug in treatment of extranodal NK/T-cell lymphoma (ENKTCL), and mechanisms resistance to ASP remain largely unknown. Long non-coding RNAs play important roles chemotherapy various cancers. However, expression BCYRN1 its role ENKTCL still unidentified. Methods: Lentivirus-mediated overexpression knockdown were performed SNK-6 cells. Cell autophagy was analyzed by adenovirus expressing GFP-LC3B fusion protein. RNA pull-down Binding Protein...
Blue rubber bleb naevus syndrome (BRBNS) is an extremely rare venous malformation that often manifests as multiple haemangioma‐like lesions in the skin and gastrointestinal tract. The drug sirolimus plays a key role signalling pathway of angiogenesis subsequent development BRBNS its use has been described several case reports. We present series four patients with who exhibited good treatment response to sirolimus. All were administered oral at doses 1.0–1.5 mg/m2/day target level 5–10 ng/mL...
Background There are no established biomarkers predictive of the efficacy treatment for ocular adnexal lymphoma (OAL). Purpose To evaluate effectiveness pretreatment dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted (DWI) in predicting response OAL to chemotherapy. Material Methods Twenty-one patients, who were pathologically diagnosed with OAL, retrospectively analyzed. According National Comprehensive Cancer Network (NCCN) evaluation criteria...
We retrospectively evaluated the long-term outcomes of patients receiving an EPOCHL (EPOCH + L-asparaginase) regimen as first-line chemotherapy for newly diagnosed extranodal natural killer/T cell lymphoma, nasal type (ENKTL). Ninety-six received 2-8 cycles EPOCHL. After 2-4 cycles, 55.2% had complete response (CR) and 39.6% partial (PR). 42.7% developed progressive or relapsed disease. The 5-year progression-free survival (PFS) rates were 56.1% overall, 59.8% stage I/II, 34.9% III/IV...
<h3>Objective:</h3> To compare the efficacy and safety of novel SVILE regimen with P-GemOx in patients newly diagnosed extranodal natural killer/T-cell lymphoma, nasal type (ND-ENKTL). <h3>Methods:</h3> From April 2015 to July 2018, 103 ND-ENKTL were randomly assigned (experimental group) or (control chemotherapy followed by radiotherapy consolidation chemotherapy. The primary endpoint was overall response rate after 3 cycles chemotherapy, secondary study endpoints complete (CR),...
Extranodal natural killer (NK)/T-cell lymphoma (ENKTCL) is an aggressive with marked heterogeneity, resulting in a distinct prognosis even patients the same disease stage. The nomogram-revised risk index (NRI) has been proposed to stratify ENKTCL. Numerous reports have revealed prognostic role of serum ferritin various cancers.We aimed evaluate NRI our single cohort ENKTCL treated uniformly, explore value ferritin, and establish new model better ENKTCL.We included 326 detailed data regarding...
Objective Extranodal natural killer/T cell lymphoma (NKTCL) is an aggressive EBV-related lymphoma, originating from NK cells or T cells. Previous study demonstrated that CD56 negative NKTCL should be recognized as a distinct subtype. In this study, the value of in validated era asparaginase, and genomic analysis was done to dissect differences between CD56-negative positive NKTCL. Methods 443 patients with newly diagnosed were enrolled retrospective correlation positivity survival outcomes...
To the Editor: Extranodal natural killer/T-cell lymphoma (ENKTCL) is a highly aggressive (NHL), closely associated with Epstein–Barr virus (EBV) infection. By using combination of radiotherapy (RT) and asparaginase-based chemotherapy, more than 70% patients early stage ENKTCL have been cured.[1] However, great challenges exist among at newly diagnosed advanced or relapsed/refractory ENKTCL. Hemophagocytic lymphohistiocytosis (HLH) fatal syndrome characterized by persistent fever, cytopenia,...
Objective To assess the impact of different treatment strategies and risk factors on prognosis patients with extranodal NK/T-cell lymphoma, nasal type (ENKTL) in a single medical center. Methods analysis The clinical features 266 ENKTL were retrospectively analyzed, among whom those stages I II received sandwich therapy, while III IV underwent chemotherapy plus autologous hematopoietic stem cell transplantation. Kaplan–Meier curves, univariate multivariate Cox regression analyses employed...
To determine the optimal variation in SUVlbm
Objective To study clinical features, treatment and prognosis of nasal NK/T cell lymphoma associated Hemophagocytic Syndrome (HPS).Methods Retrospectively analysis method was used to analyze the data 3 patients with HPS. Results fulfilled criteria All had adverse prognostic factors lymphoma.1 patient developed HPS as main primary manifestations underlying lymphoma,the other 2 during progression. In three cases, bone marrow infiltrated cells.When occurred,the disease progressed rapidly.The...
We retrospectively analyzed the treatment outcomes of elderly patients (aged ≥ 60 years) with extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) and investigated prognostic factors. Fifty-two received chemotherapy alone, radiotherapy or followed by ± consolidation as induction therapy. Overall, 97.26% in stage I/II had overall response (OR) 86.1% complete (CR), whereas 71.4% III/IV OR 35.7% CR. The 3-year freedom from progression (FFP) rate survival (OS) were 78.2% 85.0%,...
Extranodal NK/T-cell lymphoma (ENKTCL) is a highly aggressive and Epstein-Bar virus (EBV)-associated hematologic malignancy, most prevalent in the Far East South America. No standard treatment strategy has been defined. It well recognized that combination of asparaginase-based chemotherapy (CT) radiotherapy (RT) benefit early-stage ENKTCL. validated upfront RT can cure stage I patients ENKTCL without risk factors, asparaginase (either L-asparaginase or pegaspargase) backbone for
Purpose: Extranodal NK/T-cell lymphoma (ENKTCL) is a highly aggressive lymphoma, with dismal outcomes for patients advanced disease. No standard chemotherapy regimens were defined yet, especially those concurrent hemophagocytic lymphohistiocytosis (HLH). Methods: Patients stage ENKTCL treated combination of gemcitabine, pegaspargase, etoposide, and dexamethasone (GPED) since January 2020 in our center. The clinical characteristics, short-term efficacy, long-term survival outcomes, safety...
Nasal-type extranodal nature killer-T-cell lymphoma (NKTCL) originates from mature killer (NK) cell or NK-like T cell. This cells are usually CD3e, CD56 and Epstein-Barr Virus (EBV) positive the later plays an important role in pathogenesis. A number of lines animal models NKTCL have been established used experimental studies. always has various chromosome aberrations most common is 6q- which not specific for disease. Various abnormalities genes expression epigenetic also found, might...
Extranodal NK/T cell lymphoma,nasal type is a common subtype of non-Hodgkin's lymphomas in China.Many difficulties remain its diagnosis and treatment.Correct can be established according to the typical histology findings immunology phenotypes with CD33（E）,EBER and/or CD56 positive.Prognostic factors should assessed initiation diagnosis.Ann Arbor staging classification has still being widely used PET-CT scan strongly recommended.Chemotherapy followed by radiotherapy been considered for...