A5033226523- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- interferon and immune responses
- Liver Diseases and Immunity
- Drug-Induced Hepatotoxicity and Protection
- Genetic and Kidney Cyst Diseases
- Hepatitis Viruses Studies and Epidemiology
- Genetic Syndromes and Imprinting
- Cytomegalovirus and herpesvirus research
- Viral Infections and Outbreaks Research
- Pancreatitis Pathology and Treatment
- Renal and related cancers
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- Gut microbiota and health
- Thermal Regulation in Medicine
- Sepsis Diagnosis and Treatment
First Affiliated Hospital of Fujian Medical University
2016-2025
Fujian Medical University
2016-2025
Center for Digestive and Liver Diseases
2016-2023
NIHR Birmingham Liver Biomedical Research Unit
2023
Huashan Hospital
2022
Fudan University
2022
National Institute for Communicable Disease Control and Prevention
2022
Abstract B- and T-lymphocyte attenuator (BTLA) levels are increased in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). This condition is characterized by susceptibility to infection T-cell immune exhaustion. However, whether BTLA can induce exhaustion increase the risk of remains unclear. Here, we report that significantly circulating intrahepatic CD4 + T cells from HBV-ACLF, positively correlated disease severity, prognosis, complications. were upregulated...
Summary Background and Aims We aimed to define gender‐specific, optimal alanine aminotransferase (ALT) cut‐off values for the prediction of significant liver histological changes (SLHC) in Chinese patients with grey zone (GZ) chronic hepatitis B (CHB) normal ALT. Methods In a retrospective study, we included 1101 consecutive GZ CHB ALT assigned training or internal validation cohorts. an independent cohort 842 external validation. performed receiver operating characteristic (ROC) curve,...
BACKGROUND Transient elastography (FibroScan) is a new and non-invasive test, which has been widely recommended by the guidelines of chronic hepatitis B virus (HBV) management for assessing hepatic fibrosis staging. However, some confounders may affect diagnostic accuracy FibroScan device in AIM To evaluate value effect inflammation on stage liver patients with HBV infection. METHODS The data 416 infection who accepted FibroScan, biopsy, clinical, biological examination were collected from...
The association between hepatitis B surface antigen (HBsAg) and 'e' (HBeAg) levels liver inflammation fibrosis in patients with chronic (CHB) the immune clearance (IC) remains elusive. aim of present study was to investigate whether HBsAg HBeAg were associated CHB during IC phase. Kendall's rank correlation analysis receiver operating characteristic curves used determine HBsAg, pathological stages. Multivariate by forward logistic regression analyze significant predictors cirrhosis. A...
AimsThis study aimed to investigate associations between ceruloplasmin (CP) levels, inflammation grade and fibrosis stages in patients with chronic hepatitis B (CHB) establish a noninvasive model predict cirrhosis. MethodsLiver biopsy samples sera were collected from 198 CHB randomized into training group (n=109) validation (n=89). CP levels determined using nephelometric immunoassays. Relationships liver analyzed by Spearman rank correlation. Receiver operator characteristic (ROC) curves...
The microbes and metabolomics of microbiota dysbiosis in the gut different phases hepatitis B virus (HBV) infection are not fully understood.To investigate specific metabolites immune-tolerant (IT) immune-active (IA) chronic (CHB).Clinical fecal samples from healthy individuals patients IT IA HBV were collected. Next, non-target metabolomics, bioinformatics, 16S rDNA sequencing analyses performed.A total 293 14 phyla, 22 classes, 29 orders, 51 families, 190 genera identified. four phyla...
Viral load reduction facilitates recovery of antiviral T-cell responses. Dynamic alterations in intrahepatic viraemia clearance and immune cell reactivity during the early phase nucleoside analogue (NA) therapy impact these changes on HBeAg seroconversion are unknown. Fifteen HBeAg-positive chronic hepatitis B (CHB) patients were treated with adefovir dipivoxil. to HBV core surface antigens tested using ELISPOT assay from baseline week 48 post-treatment (at 4-week intervals). Before at 12...
AIMTo develop a non-invasive model to evaluate significant fibrosis and cirrhosis by investigating the association between serum ceruloplasmin (CP) levels liver in chronic hepatitis B (CHB) patients with normal or minimally raised alanine aminotransferase (ALT). METHODSSerum samples biopsy were obtained from 193 CHB ALT who randomly divided into training group (n = 97) validation 96).Liver histology was evaluated METAVIR scoring system.Receiver operator characteristic curves applied...
To establish an effective prognostic nomogram for acute-on-chronic hepatitis B liver failure (ACHBLF).The was based on clinical data of 203 ACHBLF patients who admitted to the First Affiliated Hospital Fujian Medical University from 2009 2014. The area under receiver-operating characteristic curve (AUC) and calibration were carried out verify predictive accuracy ability nomogram. result validated in internal external validation cohorts. Kaplan-Meier survival used analysis.We developed a new...
Hepatitis B e antigen (HBeAg)-positive chronic hepatitis (CHB) in the immune-tolerant (IT) phase is significantly associated with high risk for hepatocellular carcinoma, suggesting requirement antiviral therapy, particularly those histological liver injury. This study aimed to establish a non-invasive panel assess significant fibrosis IT B.One hundred and thirteen IT-phase CHB patients were retrospectively recruited divided into two histopathological groups according their profiles:...
Manganese (Mn2+) has been shown to promote type I interferon (IFN) production and activate the cyclic GMP-AMP synthase (cGAS)/Stimulator of Interferon Genes (STING) signaling pathway, suggesting that Mn2+ could be used as an adjuvant for vaccination.In present study, effects on vaccination against hepatitis B virus (HBV) were evaluated. We treated mouse hepatocytes kuppfer cells with or without adeno-associated (AAV)-HBV infection. Expression IFN-α IFN-β activation TBK1 IRF3 monitored....
Background The presence of significant liver fibrosis in hepatitis B virus (HBV)-infected individuals with persistently normal serum alanine aminotransferase (PNALT) levels is a strong indicator for initiating antiviral therapy. Serum ceruloplasmin (CP) negatively correlated HBV-infected individuals. Aim To examine the potential value CP and develop noninvasive index including to assess among PNALT. Methods Two hundred seventy-five PNALT were retrospectively evaluated. association between...
Background and AimsAspartate aminotransferase-to-platelet ratio index (APRI) fibrosis-4 (FIB-4) are widely used to assess liver fibrosis in chronic hepatitis B virus (HBV) infection. Currently, the definition of normal alanine aminotransferase (ALT) is controversial. We aimed examine diagnostic value APRI FIB-4 HBV carriers with different upper limits (ULNs) for ALT.
Abstract A proportion of chronic hepatitis B virus (HBV) carriers with normal alanine transaminase (ALT) present significant liver histological changes (SLHC). To construct a noninvasive nomogram model to identify SLHC in HBV different upper limits (ULNs) for ALT. The training cohort consisted 732 who were stratified into four sets according ULNs ALT: I, II, III, and IV. external validation comprised 277 carriers. Logistic regression least absolute shrinkage selection operator analyses...
Von Meyenburg complexes (VMCs) are a rare type of ductal plate malformation. We herein report two Chinese families with VMCs, and the suspicious gene mutation this disease. Proband A was 62-year-old woman abnormal echographic presentation liver. She received magnetic resonance imaging (MRI) examination liver biopsy, results showed she had VMCs. Histologically proved hepatocellular carcinoma found 1 year after diagnosis B 57-year-old intrahepatic diffuse lesions displayed by abdominal...
Aim To investigate the prevalence and characteristics of hepatitis B e antigen (HBeAg) negative/treatment naïve subjects with low virus (HBV) DNA levels (<104 copies/ml) alanine aminotransferase (ALT) (<2 × upper limit normal) in patients HBV-related hepatocellular carcinoma (HCC). Methods A total 226 treatment diagnosed HCC, divided into five Barcelona Clinic Liver Cancer (BCLC) stages, were enrolled retrospectively analyzed. Virological parameters including surface (HBsAg), HBeAg, HBV...
Hepatitis B surface antigen (HBsAg) levels are used to evaluate and monitor clinical phases of chronic hepatitis infection but their significance is unclear in the late complications, cirrhosis liver hepatocellular carcinoma. This study aimed HBsAg across whole natural history virus infection, including complications. retrospective, cross-sectional enrolled 838 treatment-naive patients diagnosed with at First Affiliated Hospital Fujian Medical University between 2009 2012. Patients were...
To determine whether liver stiffness measurement (LSM) indicates inflammation in chronic hepatitis B (CHB) with different upper limits of normal (ULNs) for alanine aminotransferase (ALT).We grouped 439 CHB patients using ULNs ALT: cohort I, ≤40 U/L (439 subjects); II, ≤35/25 (males/females; 330 and III, ≤30/19 231 subjects). Furthermore, 84 96 ALT (≤40 U/L) formed the external prospective validation groups, respectively. We evaluated correlation between LSM biopsy-confirmed inflammation,...
Objective Patients with chronic hepatitis B (CHB) often fail to achieve clearance of the surface antigen (HBsAg) peginterferon treatment. Our study aimed develop a simple-to-use scoring system predict likelihood HBsAg following treatment alfa-2b(PEG-IFN-α2b) in patients CHB. Methods A total 231 were enrolled and divided into ( n = 37) non-HBsAg 194) groups. Multifactor logistic models constructed using univariate multiple regression analyses. The area under receiver operating characteristic...
This study aimed to investigate the changes of toll-like receptor 4 (TLR4), proinflammatory cytokine expression, hepatitis B virus surface antigen (HBsAg), and envelope (HBeAg) expression as well innate immune cell percentages in a mouse model persistent (HBV) infection better understand response. Mouse models HBV infection, HBsAg HBeAg were developed using high-pressure tail-vein injection recombinant adeno-associated viruses. Enzyme-linked immunosorbent assays (ELISAs) used determine serum...