A5100549359- Pickering emulsions and particle stabilization
- Proteins in Food Systems
- Asymmetric Hydrogenation and Catalysis
- Semiconductor materials and devices
- Diet, Metabolism, and Disease
- Pancreatic and Hepatic Oncology Research
- Catalytic C–H Functionalization Methods
- Synthetic Organic Chemistry Methods
- Pharmacological Effects and Toxicity Studies
- Immune Cell Function and Interaction
- Food Chemistry and Fat Analysis
- Renal Transplantation Outcomes and Treatments
- High Temperature Alloys and Creep
- Asymmetric Synthesis and Catalysis
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Advanced Cellulose Research Studies
- Advanced Materials and Mechanics
- Cholesterol and Lipid Metabolism
- Additive Manufacturing and 3D Printing Technologies
- Astro and Planetary Science
- Inflammation biomarkers and pathways
- Intermetallics and Advanced Alloy Properties
- Ferroptosis and cancer prognosis
- Mycobacterium research and diagnosis
- Diatoms and Algae Research
First Affiliated Hospital of Fujian Medical University
2023-2025
Fujian Medical University
2023-2025
Beijing University of Chinese Medicine
2025
Northeast Forestry University
2023-2024
Dalian Institute of Chemical Physics
2023-2024
Chinese Academy of Sciences
2023-2024
Tianjin Fourth Central Hospital
2024
Shandong University
2024
Soochow University
2024
Dalian University of Technology
2024
The T-cell surface molecule TIGIT is an immune checkpoint that inhibits responses, but its roles in cancer are little understood. In this study, we evaluated the role plays development and progression of gastric cancer. We show percentage CD8 T cells TIGIT+ was increased patients compared with healthy individuals. These showed functional exhaustion impaired activation, proliferation, cytokine production, metabolism, all which were rescued by glucose. addition, tissue cell lines expressed...
Mycobacterium tuberculosis (Mtb) is the leading infectious disease killer worldwide. We discovered that intracellular Mtb fails to grow in macrophages which fatty acid β-oxidation (FAO) blocked. Macrophages treated with FAO inhibitors rapidly generate a burst of mitochondria-derived reactive oxygen species, promotes NADPH oxidase recruitment and autophagy limit growth Mtb. Furthermore, we demonstrate ability trimetazidine reduce pathogen burden mice infected These studies will add knowledge...
Tacrolimus is extensively used for the prevention of graft rejection following solid organ transplantation in pregnant women. However, knowledge gaps dosage tacrolimus patients with different CYP3A5 genotypes and infection conditions have been identified. This study aimed to develop a physiologically based pharmacokinetic (PBPK) model characterize maternal fetal pharmacokinetics during pregnancy explore provide adjustments. We developed PBPK models nonpregnant validated them via data from...
Abstract Pancreatic cancer (PC) has the poorest prognosis compared to other common cancers because of its aggressive nature, late detection, and resistance systemic treatment. In this study, we aimed identify novel biomarkers for PC patients further explored their function in progression. We analyzed GSE62452 GSE28735 datasets, identifying 35 differentially expressed genes (DEGs) between specimens non-tumors. Based on DEGs, performed machine learning identified eight diagnostic involved...
The rapid development of deep learning techniques has driven the emergence a neural network-based variational Monte Carlo method (referred to as FermiNet), which manifested high accuracy and strong predictive power in electronic structure calculations atoms, molecules well some periodic systems. Recently, implementation effective core potential (ECP) scheme it further facilitates more efffcient practice. But there still lack comprehensive assessments on ECP's performance under FermiNet. In...
The circadian clock genes are known important for kidney development, maturation and physiological functions. However, whether how they play a role in renal regeneration remain elusive. Here, by using the single cell RNA-sequencing (scRNA-seq) technology, we investigated dynamic gene expression profiles states after acute injury (AKI) gentamicin treatment zebrafish. core such as per1/2 nr1d1, which encode transcriptional repressors of system, strongly induced proximal tubule epithelial cells...
Abstract Nickel-based single-crystal superalloys are crucial materials for the preparation of aero-engine turbine blades. Many solute elements added to strengthening. However, relationship between clustering behavior atoms and properties nickel-based is still unclear. Herein, we conduct first-principles calculations on γ phases with Mo−Mo Mo−Mo−Ru clusters reveal possibility stabilizing mechanism clusters. Introducing Mo lowers total energy, binding formation energy phase due replacement...
We present a palladium-catalyzed asymmetric hydrogenation of lactones under base-free conditions through DKR and KR with high enantioselectivity. This work provides new strategy for esters conditions.
<title>Abstract</title> Aqueous two-phase systems (ATPS) with multifunctional attributes have significant promise as biomimetic materials, but current approaches do not harness their full potential. We show that ATPSs can be stabilized to form microcapsules by the interfacial assembly of chitin nanofibers (ChNF) and rod-like cellulose nanocrystals (CNC). The high structural stability ChNF/CNC complex integrates permeability transport across membrane at liquid/liquid interface. Driven density...
Three-dimensional (3D) integration based on through-silicon-via (TSV) technology provides a solution to the miniaturization of electronic systems. In this paper, novel integrated passive devices (IPDs) including capacitor, inductor, and bandpass filter are designed by employing TSV structures. For lower manufacturing costs, polyimide (PI) liners used in TSVs. The influences structural parameters TSVs electrical performance TSV-based capacitor inductor individually evaluated. Moreover, with...