Lindsey A. Roth
A5017217536- Asthma and respiratory diseases
- Genetic Associations and Epidemiology
- IL-33, ST2, and ILC Pathways
- Epigenetics and DNA Methylation
- Allergic Rhinitis and Sensitization
- Assisted Reproductive Technology and Twin Pregnancy
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Noise Effects and Management
- Respiratory and Cough-Related Research
- Maternal and Perinatal Health Interventions
- School Health and Nursing Education
- Occupational exposure and asthma
- Immunodeficiency and Autoimmune Disorders
- Health, psychology, and well-being
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Preterm Birth and Chorioamnionitis
- Nutrition, Genetics, and Disease
- Helicobacter pylori-related gastroenterology studies
- Occupational and environmental lung diseases
- Breastfeeding Practices and Influences
- Genetic diversity and population structure
- Intestinal Malrotation and Obstruction Disorders
- Indoor Air Quality and Microbial Exposure
- Maternal and fetal healthcare
New York University
1952-2024
NYU Langone Health
2021-2022
University of California, San Francisco
2011-2018
Pulmonary and Critical Care Associates
2014
California Environmental Protection Agency
2008-2010
Epidemiologic studies have demonstrated an association between acute exposure to ambient fine particles and both mortality morbidity. Less is known about the relative impacts of specific chemical constituents particulate matter<2.5 microm in aerodynamic diameter (PM2.5) on hospital admissions.This study was designed estimate risks PM2.5 several species admissions for respiratory diseases among children.We obtained data daily counts hospitalizations children<19 <5 years age total...
Air pollution is a known asthma trigger and has been associated with short-term symptoms, airway inflammation, decreased lung function, reduced response to rescue medications.To assess causal relationship between air childhood using data that address temporality by estimating exposures before the development of establish generalizability association studying diverse racial/ethnic populations in different geographic regions.This study included Latino (n = 3,343) African American 977)...
Obesity is associated with increased asthma morbidity, lower drug responsiveness to inhaled corticosteroids, and worse control. However, most prior investigations on obesity control have not focused pediatric populations, considered environmental exposures, or included minority children.To examine the association between body mass index categories among boys girls; whether these associations are modified by age race/ethnicity.Children adolescents ages 8-19 years (n = 2,174) were recruited...
The burden of asthma is highest among socioeconomically disadvantaged populations; however, its impact differentially distributed racial and ethnic groups.To assess the collective effect maternal educational attainment, annual household income, insurance type on childhood minority, urban youth.We included Mexican American (n = 485), other Latino 217), African 1,141) children (aged 8-21 yr) with without from San Francisco Bay Area. An index was derived to socioeconomic status predicting...
Contemporary genetic variation among Latin Americans human groups reflects population migrations shaped by complex historical, social and economic factors. Consequently, admixture patterns may vary geographic regions ranging from countries to neighborhoods. We examined the of across island Puerto Rico degree which it could be explained historic events. analyzed a census-based sample 642 Rican individuals that were genotyped for 93 ancestry informative markers (AIMs) estimate African,...
Asthma is a chronic inflammatory disease with strong genetic predisposition. A major challenge for candidate gene association studies in asthma the selection of biologically relevant genes.Using epithelial RNA expression arrays, HapMap allele frequency variation, and literature, we identified six possible susceptibility genes childhood including ADCY2, DNAH5, KIF3A, PDE4B, PLAU, SPRR2B. To evaluate these genes, compared genotypes 194 predominantly tagging SNPs 790 asthmatic, allergic...
African Americans are disproportionately burdened by asthma. We assessed the individual and joint contribution of socioeconomic status (SES) on asthma morbidity among American youth.We examined 686 (8-21 years) with To account for effects SES, a composite index was derived from maternal educational attainment, household income, insurance status. Ordinal logistic regression used to estimate effect SES control. Models were adjusted age, sex, controller medication use, in utero smoke exposure,...
Asthma is a complex genetic disease caused by combination of and environmental risk factors. We sought to test classes variants largely missed genome-wide association studies (GWAS), including copy number (CNVs) low-frequency variants, performing whole-genome sequencing (WGS) on 16 individuals from asthma-enriched asthma-depleted families. The samples were obtained an extended 13-generation Hutterite pedigree with reduced heterogeneity due small founding gene pool as result communal...
Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, homologous genomic regions associated with AHR human asthma-related phenotypes. Our goal was to identify genes integrating associations genome-wide association study (GWAS) data. We used Efficient Mixed Model Association (EMMA) analysis conduct GWAS baseline measures from males females 31 strains. Genes near or containing SNPs...