A5032692244- Forensic and Genetic Research
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Genetic Associations and Epidemiology
- Genetics, Bioinformatics, and Biomedical Research
- Cuban History and Society
- Evolution and Paleontology Studies
- Biomedical and Engineering Education
- Genomics and Rare Diseases
- Race, Genetics, and Society
- RNA and protein synthesis mechanisms
- Forensic Anthropology and Bioarchaeology Studies
- Genetic and phenotypic traits in livestock
- Career Development and Diversity
- Digestive system and related health
- Nutrition, Genetics, and Disease
- Neurobiology and Insect Physiology Research
- Species Distribution and Climate Change
- Historical and Cultural Archaeology Studies
- CRISPR and Genetic Engineering
- Immunodeficiency and Autoimmune Disorders
- Plant Reproductive Biology
- Chromosomal and Genetic Variations
- Plant and animal studies
- Amphibian and Reptile Biology
University of Puerto Rico-Mayaguez
2013-2022
Martinez VA Medical Center
2022
Ponce Health Sciences University
2017
Arizona State University
2017
University of Puerto Rico System
2006-2010
Fred Hutch Cancer Center
2006
Kaiser Permanente
2006
University of California, San Francisco
2006
Northwestern University
2006
Columbia University
2006
The Caribbean basin is home to some of the most complex interactions in recent history among previously diverged human populations. Here, we investigate population genetic this region by characterizing patterns genome-wide variation 330 individuals from three Greater Antilles (Cuba, Puerto Rico, Hispaniola), two mainland (Honduras, Colombia), and Native South American (Yukpa, Bari, Warao) We combine these data with a unique database genomic over 3,000 diverse European, African, use local...
There is great scientific and popular interest in understanding the genetic history of populations Americas. We wish to understand when different regions continent were inhabited, where settlers came from, how current inhabitants relate genetically earlier populations. Recent studies unraveled parts using genotyping arrays uniparental markers. The 1000 Genomes Project provides a unique opportunity for improving our population by providing over hundred sequenced low coverage genomes exomes...
There is widespread agreement that science, technology, engineering, and mathematics programs should provide undergraduates with research experience. Practical issues limited resources, however, make this a challenge. We have developed bioinformatics project provides course-based experience for students at diverse group of schools offers the opportunity to tailor local curriculum institution-specific student needs. assessed both attitude knowledge gains, looking insights into how respond...
Contemporary genetic variation among Latin Americans human groups reflects population migrations shaped by complex historical, social and economic factors. Consequently, admixture patterns may vary geographic regions ranging from countries to neighborhoods. We examined the of across island Puerto Rico degree which it could be explained historic events. analyzed a census-based sample 642 Rican individuals that were genotyped for 93 ancestry informative markers (AIMs) estimate African,...
In their 2012 report, the President's Council of Advisors on Science and Technology advocated “replacing standard science laboratory courses with discovery-based research courses”—a challenging proposition that presents practical pedagogical difficulties. this paper, we describe our collective experiences working Genomics Education Partnership, a nationwide faculty consortium aims to provide undergraduates experience in genomics through scheduled course (a classroom-based undergraduate...
The haplogroup identities of 800 mtDNAs randomly and systematically selected to be representative the population Puerto Rico were determined by restriction fragment length polymorphism (RFLP), revealing maternal ancestries in this highly mixed 61.3% Amerindian, 27.2% sub-Saharan African, 11.5% West Eurasian. Eurasian frequencies low all 28 municipalities sampled, displayed no geographic patterns. Thus, a statistically significant negative correlation was observed between Amerindian African...
Puerto Ricans, an admixed population of African, European, and Native American ancestries, have the highest asthma prevalence, morbidity, mortality rates any United States' population. Although socioeconomic status (SES) is negatively correlated with incidence in most populations, no such relationship has been identified among Ricans. We hypothesized that, this population, association between SES may interact genetic ancestry.We analyzed 135 Rican subjects 156 control recruited from six...
A hallmark of the research experience is encountering difficulty and working through those challenges to achieve success. This ability essential being a successful scientist, but replicating such in teaching setting can be difficult. The Genomics Education Partnership (GEP) consortium faculty who engage their students genomics Course-Based Undergraduate Research Experience (CURE). Students participate genome annotation, generating gene models using multiple lines experimental evidence. Our...
To estimate the maternal contribution of Native Americans to human gene pool Puerto Ricans--a population mixed African, European, and Amerindian ancestry--the mtDNAs two sample sets were screened for restriction fragment length polymorphisms (RFLPs) defining four major American haplogroups. The set collected from people who claimed have a ancestor with physiognomic traits had statistically significant higher frequency (69.6%) than did unbiased (52.6%). This suggests that, despite fact that...
Abstract We have isolated clones corresponding to the autosomal chorion locus of Drosophila melanogaster, from two distantly (D. virilis and D. grimshawi) one closely subobscura) related species. In all species is unique within genome encompasses same four genes an adjacent nonchorion gene, in order. specifically amplifies ovary, as melanogaster. present nucleotide sequences DNA segments that total 8.3 kb length include gene s15-1 subobscura, virilis, grimshawi well s19-1 subobscura...
In a previous study, Keith (1983) showed by sequential gel electrophoresis of the esterase-5 protein in Drosophila pseudoobscura that highly polymorphic locus with many alleles can have very similar frequency distributions populations separated 500 km. The present work studies another locus, xanthine dehydrogenase, same California population samples, using technique to distinguish allelic classes. Twelve electromorphs were found one and 15 other. Both shared single frequent (approximately...
Abstract Since the first Spanish settlers brought horses to America centuries ago, several local varieties and breeds have been established in New World. These were generally a consequence of admixture different arriving from Europe. In some instances, selectively bred for specific traits, such as appearance, endurance, strength, gait. We looked at genetics two breeds, Puerto Rican Non-Purebred (PRNPB) (also known “Criollo”) Paso Fino (PRPF), Caribbean Island Rico. While it is reasonable...
The Genomics Education Partnership (GEP) engages students in a course-based undergraduate research experience (CURE). To better understand the student attributes that support success this CURE, we asked about their attitudes using previously published scales measure epistemic beliefs work and science, interest grit. We found, general, bring with them into classroom contribute to two outcome measures, namely, learning as assessed by pre- postquiz perceived self-reported benefits. While GEP...
Abstract Risk genes for Mendelian (single-gene) disorders (SGDs) are consistent across populations, but pathogenic risk variants that cause SGDs typically population-private. The goal was to develop “QChip1,” an inexpensive genotyping microarray comprehensively screen newborns, couples, and patients SGD in Qatar, a small nation on the Arabian Peninsula with high degree of consanguinity. Over 10 8 8445 Qatari were identified inclusion array containing 165,695 probes 83,542 known potentially...
Solenodons are insectivores that live in Hispaniola and Cuba. They form an isolated branch the tree of placental mammals highly divergent from other eulipothyplan The history, unique biology, adaptations these enigmatic venomous species could be illuminated by availability genome data. However, a whole assembly for solenodons has not been previously performed, partially due to difficulty obtaining samples field. Island isolation reduced numbers have likely resulted high homozygosity within...
Solenodons are insectivores found only in Hispaniola and Cuba, with a Mesozoic divergence date versus extant mainland mammals. the oldest lineage of living eutherian mammal for which mitogenome sequence has not been reported. We determined complete sequences six Hispaniolan solenodons (Solenodon paradoxus) using next-generation sequencing. The solenodon mitogenomes were 16,454-16,457 bp long carried expected repertoire genes. A mitogenomic phylogeny confirmed basal position relative to...
Little is known about the natural history of Sphaerodactylus species endemic to three islands located in Mona Passage separating Greater Antillean Hispaniola and Puerto Rico. In this study, parts two mitochondrial genes, 16S rRNA 12S rRNA, were sequenced determine relationships between sphaerodactylids that live other Caribbean from same genus. While main goal was identify biogeographical origin these species, we also identified a genetically distinct type dwarf gecko warrants future...
Islands have been used as model systems for studies of speciation and extinction since Darwin published his observations about finches found on the Galapagos. Amazon parrots inhabiting Greater Antillean represent a fascinating species diversification. Unfortunately, many these birds are threatened result human activity some, like Puerto Rican parrot, now critically endangered. In this study we combination de novo reference-assisted assembly methods, integrating it with information obtained...
Maternal lineages of West Eurasian and North African origin account for 11.5% total mitochondrial ancestry in Puerto Rico. Historical sources suggest that this arrived mostly from European migrations took place during the four centuries Spanish colonization This study analyzed 101 control region sequences diagnostic coding variants a sample set randomly systematically selected using census-based sampling frame to be representative Rican population, with goal defining Eurasian-North maternal...
Objetivo: Este trabajo integra información de la secuencia del ADNmt norte Suramérica con Puerto Rico, el fin comprender poblamiento Caribe, especialmente los taínos. De paso, arroja sobre hechos demográficos en Colombia precolombina.Metodología: Se obtuvieron 59 muestras y Venezuela, las cuales fueron analizadas junto a otras dos pertenecientes indios warao disponibles Genbank. alinearon secuencias HVR-I II (Hypervariable Region) se compararon rCRS. El 93,4% resultaron ser origen...