A5074503965- Antimicrobial Peptides and Activities
- Probiotics and Fermented Foods
- Enzyme-mediated dye degradation
- Polydiacetylene-based materials and applications
- Antifungal resistance and susceptibility
- Forensic Anthropology and Bioarchaeology Studies
- COVID-19 and healthcare impacts
- Microbial bioremediation and biosurfactants
- Fermentation and Sensory Analysis
- Biochemical and Structural Characterization
- Race, Genetics, and Society
- Protein Hydrolysis and Bioactive Peptides
- Forensic and Genetic Research
- Diversity and Career in Medicine
- Advanced Materials and Mechanics
- Alcohol Consumption and Health Effects
- Nail Diseases and Treatments
- Hydrogels: synthesis, properties, applications
- Lipid Membrane Structure and Behavior
- Vanadium and Halogenation Chemistry
- Lichen and fungal ecology
- Fungal Infections and Studies
- Plant Disease Resistance and Genetics
- Polymer composites and self-healing
University of Puerto Rico-Mayaguez
2015-2023
University of Wisconsin–Madison
2003-2007
Mayo Clinic
1998
Soils and decayed plant litter contain significant quantities of chlorinated aromatic polymers that have a natural but largely unknown origin. We used cupric oxide ligninolysis coupled with gas chromatography/mass spectrometry to show Curvularia inaequalis, widely distributed ascomycete, the rings lignin in wood it was degrading. In aspen for 24 weeks, two chlorolignin fragments, 5-chlorovanillin 2-chlorosyringaldehyde, were each found at approximately 10 mug/g (dry weight). These levels...
ABSTRACT Two fungal chloroperoxidases (CPOs), the heme enzyme from Caldariomyces fumago and vanadium Curvularia inaequalis , chlorinated 1-(4-ethoxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1,3-dihydroxypropane, a dimeric model compound that represents major nonphenolic structure in lignin. Both enzymes also cleaved this dimer to give 1-chloro-4-ethoxy-3-methoxybenzene 1,2-dichloro-4-ethoxy-5-methoxybenzene, they depolymerized synthetic guaiacyl Since CPOs occur soils fungi produce them are...
To estimate the maternal contribution of Native Americans to human gene pool Puerto Ricans--a population mixed African, European, and Amerindian ancestry--the mtDNAs two sample sets were screened for restriction fragment length polymorphisms (RFLPs) defining four major American haplogroups. The set collected from people who claimed have a ancestor with physiognomic traits had statistically significant higher frequency (69.6%) than did unbiased (52.6%). This suggests that, despite fact that...
For over 3 decades, sexual development in the human fungal pathogen Cryptococcus neoformans and other fungi has been initiated by growing compatible mating partners on V8 juice medium. Although this medium is an efficient inducer of development, mechanism which it promotes process unknown. To understand how induces we attempted to purify inducing factors from juice, carried out a complete compositional analysis juice. We discovered that no single factor responsible for effects Rather, unique...
Fungal infections are a pressing concern for human health worldwide, particularly immunocompromised individuals. Current challenges such as the elevated toxicity of common antifungal drugs and emerging resistance towards these could be overcome by multidrug therapy. Natural antimicrobial peptides, AMPs, in combination with other agents promising avenue to address prevailing challenges. However, they possess limited biostability susceptibility proteases, which has significantly hampered their...
The widespread distribution of fungal infections, with their high morbidity and mortality rate, is a global public health problem. increase in the population immunocompromised patients combined selectivity currents treatments emergence drug-resistant strains are among most imperative reasons to develop novel antifungal formulations. Antimicrobial β-peptides peptidomimetics natural antimicrobial peptides (AMPs), which have been proposed as developmental platforms enhance AMPs biostability....
Case Western Reserve University (CWRU)/University Hospitals Cleveland Medical Center in Cleveland, OH, and the of Pittsburgh (Pitt) Pittsburgh, PA, forged a strategic alliance to form Rustbelt for AIDS Research. The Research developed National Institutes Health-supported diversity, equity, inclusion pathway initiative termed "Rustbelt Investigators Next Generation (RING) Program" that provides research training experiences Puerto Rican students will help them pursue biomedical career HIV.
Summary Synthetic peptidomimetics of antimicrobial peptides are promising as drug candidates because they promote membrane disruption and exhibit greater structural proteolytic stability. We previously reported selective antifungal 14-helical β-peptides, but the mechanism toxicity β-peptides remains unknown. To provide insight into mechanism, we studied β-peptide binding to artificial membranes living Candida albicans cells. investigated ability interact with permeate small unilamellar...