A5056962059- Innovative Microfluidic and Catalytic Techniques Innovation
- Chemical Synthesis and Analysis
- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Click Chemistry and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Data Visualization and Analytics
- Insect and Pesticide Research
- Oxidative Organic Chemistry Reactions
- Synthesis and Biological Evaluation
- Insect symbiosis and bacterial influences
- Chemical Synthesis and Reactions
- Experimental Learning in Engineering
- X-ray Diffraction in Crystallography
- Venomous Animal Envenomation and Studies
- Genetics, Bioinformatics, and Biomedical Research
- Nanomaterials for catalytic reactions
- Biomedical and Engineering Education
- Radical Photochemical Reactions
- Protein purification and stability
- Complex Network Analysis Techniques
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Animal Behavior and Reproduction
- Catalytic C–H Functionalization Methods
University of Reading
2015-2024
University of North Texas
2017
Massachusetts Institute of Technology
2014-2016
San Francisco State University
2009-2014
University of Manchester
2013-2014
University of Cambridge
2006-2011
Lawrence Berkeley National Laboratory
2010
Webster University
2010
Dalhousie University
2009
Innovative Technology and Science (United Kingdom)
2007
Parasitoid Wasp Genomes wasps, which prey on and reproduce in host insect species, play important roles plant herbivore interactions, may provide valuable tools the biological control of pest species. The Nasonia Genome Working Group (p. 343 ; see news story by Pennisi ) presents genome three very closely related species: vitripennis, N. giraulti , longicornis . findings document rapid evolution between a endosymbiont that can cause nuclear-cytoplasmic incompatibilities affect speciation.
Ants are some of the most abundant and familiar animals on Earth, they play vital roles in terrestrial ecosystems. Although all ants eusocial, display a variety complex fascinating behaviors, few genomic resources exist for them. Here, we report draft genome sequence particularly widespread well-studied species, invasive Argentine ant ( Linepithema humile ), which was accomplished using combination 454 (Roche) Illumina sequencing community-based funding rather than federal grant support....
We report the draft genome sequence of red harvester ant, Pogonomyrmex barbatus . The was sequenced using 454 pyrosequencing, and current assembly annotation were completed in less than 1 y. Analyses conserved gene groups (more 1,200 manually annotated genes to date) suggest a high-quality comparable recently insect genomes Sanger sequencing. ant is model for studying reproductive division labor, phenotypic plasticity, sociogenomics. Although P. similar other hymenopterans ( Apis mellifera...
Leaf-cutter ants are one of the most important herbivorous insects in Neotropics, harvesting vast quantities fresh leaf material. The use leaves to cultivate a fungus that serves as colony's primary food source. This obligate ant-fungus mutualism is few occurrences farming by non-humans and likely facilitated formation their massive colonies. Mature leaf-cutter ant colonies contain millions workers ranging size from small garden tenders large soldiers, resulting complex polymorphic caste...
Multistep in flow: The Seyferth-Gilbert reagent 1 has been applied a flow system to rapidly synthesize terminal alkynes. further triazole 3 from alcohol 2 three-step oxidation/homologation/copper(I)-catalyzed azide-alkyne cycloaddition sequence without isolation of intermediates (see scheme).
There is widespread agreement that science, technology, engineering, and mathematics programs should provide undergraduates with research experience. Practical issues limited resources, however, make this a challenge. We have developed bioinformatics project provides course-based experience for students at diverse group of schools offers the opportunity to tailor local curriculum institution-specific student needs. assessed both attitude knowledge gains, looking insights into how respond...
A mild method for regioselective formation of 1,5-substituted 1,2,3-triazoles is described. The zinc-mediated reaction works at room temperature and successful across a wide range azido/alkynyl substrates. Additionally, the triazole 4-position can be further functionalized through intermediate aryl-zinc to accommodate diverse three-component coupling strategy.
Honey bee colonies are subject to numerous pathogens and parasites. Interaction among multiple parasites is the proposed cause for Colony Collapse Disorder (CCD), a syndrome characterized by worker bees abandoning their hive. Here we provide first documentation that phorid fly Apocephalus borealis, previously known parasitize bumble bees, also infects eventually kills honey may pose an emerging threat North American apiculture. Parasitized show hive abandonment behavior, leaving hives at...
The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions carboxylic acids in the presence diphenylphosphoryl azide and trapping intermediate isocyanates with various nucleophiles.
The cycloaddition of acetylenes with azides to give the corresponding 1,4-disubstituted 1,2,3-triazoles is reported using immobilised reagents and scavengers in pre-packed glass tubes a modular flow reactor.
A multipurpose mesofluidic flow reactor capable of producing gram quantities material has been developed as an automated synthesis platform for the rapid on-demand key building blocks and small exploratory libraries. The is configured to provide maximum flexibility screening reaction parameters that incorporate on-chip mixing columns solid supported reagents expedite chemical syntheses.
The preparation and use of an azide-containing monolithic reactor is described for in a flow chemistry device particular conducting Curtius rearrangement reactions via acid chloride inputs.
Here we describe general flow processes for the synthesis of alkyl and aryl azides, development a new monolithic triphenylphosphine reagent, which provides convenient format use this versatile reagent in flow. The utility these tools was demonstrated by their application to Staudinger aza-Wittig reaction sequence. Finally, multistep aza-Wittig, reduction purification process designed, allowing access amine products an automated fashion.
In their 2012 report, the President's Council of Advisors on Science and Technology advocated “replacing standard science laboratory courses with discovery-based research courses”—a challenging proposition that presents practical pedagogical difficulties. this paper, we describe our collective experiences working Genomics Education Partnership, a nationwide faculty consortium aims to provide undergraduates experience in genomics through scheduled course (a classroom-based undergraduate...
A segmented flow-based microreactor is used for the continuous production of faceted nanocrystals. Flow segmentation proposed as a versatile tool to manipulate reduction kinetics and control growth nanostructures; tuning size shape. Switching gas from oxygen carbon monoxide permits adjustment in nanostructure 1D (nanorods) 2D (nanosheets). CO key factor formation Pd nanosheets Pt nanocubes; operating second phase, reductant, capping agent. This combination confines specific structures. In...
A general flow process for the multi-step assembly of peptides has been developed and this procedure used to successfully construct a series Boc, Cbz Fmoc N-protected dipeptides in excellent yields purities, including an extension method enable preparation tripeptide derivative.
Abstract Mehrstufig und fließend: Das Seyferth‐Gilbert‐Reagens 1 wurde in einem Durchfluss‐System zur schnellen Synthese von terminalen Alkinen eingesetzt. Weitere Anwendung fand das System bei der des Triazols 3 aus dem Alkohol 2 einer dreistufigen Sequenz Oxidation, Homologisierung Kupfer(I)‐katalysierter Azid‐Alkin‐Cycloaddition ohne Isolierung Zwischenstufen (siehe Schema). magnified image
Background DNA methylation is a common regulator of gene expression, including acting as developmental events and behavioral changes in adults. Using the unique system genetic caste determination Pogonomyrmex barbatus, we were able to document during development, also across both ancient contemporary hybridization events. Methodology/Principal Findings Sodium bisulfite sequencing demonstrated vivo symmetric CG dinucleotides P. barbatus. We found non-CpG sequences. This validated two...
The Pd-catalyzed aminocarbonylation of aromatic bromides was investigated in both a silicon microreactor and packed-bed tubular reactor. An automated transient temperature ramp method with in-line IR analysis led to significantly more rapid determination reaction kinetics than traditional steady-state screening for offline GC analysis.
The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used prepare various amides tri-substituted guanidines from situ generated iminophosphoranes.
A scalable method for the preparation of 4,5-disubstituted thiazoles and imidazoles as distinct regioisomeric products using a modular flow microreactor has been devised. The process makes use microfluidic reaction chips packed immobilized-reagent columns to effect bifurcation pathway.
Many network visualizations make the assumption that an administrator has previously determined subset of data should be visualized. Yet problem remains if visualization provides no insight into events warrant further consideration, then must go back to determine what visualized next. This is a critical issue given amount under only small portion which can examined at any one time. In this paper we present context for by providing high-level view events. Our not starting point visualization,...
Herein we describe a facile protocol for the reduction of aromatic ketones and aldehydes to corresponding methylene unit. The procedure involves isolation carbomethoxyhydrazone intermediate that is easily decomposed reduced product without requirement large quantities pernicious hydrazine.