A5086052147- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Pediatric health and respiratory diseases
- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
- Blood disorders and treatments
- Respiratory and Cough-Related Research
- Cystic Fibrosis Research Advances
- Pneumocystis jirovecii pneumonia detection and treatment
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Autoimmune and Inflammatory Disorders
- Inflammasome and immune disorders
- Mast cells and histamine
- Mycobacterium research and diagnosis
- Chronic Lymphocytic Leukemia Research
- Autoimmune Bullous Skin Diseases
- Infections and bacterial resistance
- Viral-associated cancers and disorders
- Indoor Air Quality and Microbial Exposure
Case Western Reserve University
2011-2023
Nationwide Children's Hospital
2023
University Hospitals of Cleveland
2004-2022
Mayfield Brain & Spine
2016-2020
Lake Erie College of Osteopathic Medicine
2020
Allergy Associates Research Center
2009-2019
Richmond University Medical Center
2011-2016
University Hospitals Landerbrook Health Center
2016
University Hospitals Cleveland Medical Center
2015
Regional Medical Center
2014
Obesity is associated with increased asthma morbidity, lower drug responsiveness to inhaled corticosteroids, and worse control. However, most prior investigations on obesity control have not focused pediatric populations, considered environmental exposures, or included minority children.To examine the association between body mass index categories among boys girls; whether these associations are modified by age race/ethnicity.Children adolescents ages 8-19 years (n = 2,174) were recruited...
X‐linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by marked reduction in all classes of serum immunoglobulins and the near absence mature CD19 + B‐cells. Although malignancy has been observed patients with XLA, we present first reported case acute myeloid leukemia (AML) patient XLA. We also demonstrate complete correction XLA phenotype following allogeneic hematopoietic cell transplantation for treatment patient's leukemia. Pediatr Blood Cancer 2015;62:1674–1676....
Summary Background Leukotrienes play an important role in allergic and inflammatory diseases, but reports on the involvement of arachidonate 5‐lipoxygenase‐activating protein (ALOX5AP) leukotriene A 4 hydrolase (LTA4H) asthma have been inconclusive. Objective To determine whether polymorphisms ALOX5AP LTA4H genes are risk factors for two different Latino groups: Mexicans Puerto Ricans. Methods The gene was sequenced individuals from both groups to identify novel polymorphisms....
The effects of in utero tobacco smoke exposure on childhood respiratory health have been investigated, and outcomes inconsistent.To determine if is associated with persistent asthma Mexican, Puerto Rican, black children.There were 295 asthmatic children, aged 8 to 16 years, who underwent spirometry, clinical data collected from the parents during a standardized interview. effect development related was evaluated by logistic regression.Children had higher odds smoke, but not current than did...
Allergy skin testing is considered a safe method for IgE-mediated allergic responses although anaphylactic events can occur. Reported rates of anaphylaxis per patient are not consistent and range from 0.008 to 4%. The aim this study was determine the rate epinephrine use associated with allergy skin-prick (SPT) intradermal (IDT) in suburban practice over 13 years. This retrospective chart review used billing procedure coding records during time period January 1997 June 2010 identify...
Abstract Introduction Anaphylaxis is a life threatening systemic inflammatory process that share mediators involved in the coagulation cascade. Platelet activating factor, known to increase platelet aggregation, has also been implicated as an important mediator of anaphylaxis. Although other reactions are associated with increased risk thrombosis, anaphylaxis currently not reported one them. Furthermore role platelets may have perianaphylaxis period well understood. We here present...
Hyper-IgE syndrome (HIES), or Jobs disease, is a rare immunologic disorder characterized by the triad of staphylococcal abscesses, pneumonia with pneumatocele formation, and elevated IgE. It has been shown to have multiple modes inheritance, autosomal dominant being more common than recessive, sporadic cases as well. A mutation in signal transducer activator transcription 3 (STAT3) gene linked development forms HIES. Peripheral eosinophilia, typically greater two standard deviations from...
The i.v. immunoglobulin (IVIG) therapy is one of the mainstays treatment for humoral immunodeficiencies, but there limited knowledge adverse reactions associated with this therapy, especially occurring in postinfusion period. purpose prospective, observational, multicenter study was to identify and quantify that can occur both during after IVIG infusions (Gamimune N) patients immunodeficiency. Patients primary immunodeficiencies requiring were followed over a 6-month period, data regarding...
Introduction: Heterozygous mutations in signal transducer and activator of transcription 1 (STAT1) have been associated with selective deficiencies to mycobacterial or fungal infections. Recent reports revealed that patients found carry de novo heterozygous STAT1 encoding specific amino acid substitutions can go on develop progressive combined immunodeficiency, distinct from the limited susceptibilities infection previously reported for mutations. Objectives: We present a case mother her son...