Abstract Objective —To determine whether dogs with naturally occurring canine parvoviral (CPV) enteritis have laboratory evidence of hypercoagulability. Design —Case-control study. Animals —9 CPV and 9 age-matched control dogs. Procedure —Blood was collected from all within 24 hours admission for thromboelastography (TEG) determination activated partial thromboplastin time (aPTT), prothrombin (PT), antithrombin III (AT) activity, fibrinogen concentration. Fibrin-fibrinogen degradation...

Abstract Objective: To describe the technique of thromboelastography (TEG) and review applications this coagulation test in humans small animals. Data sources: sources included scientific reviews original research publications. Human data synthesis: TEG has been used for documentation hypercoagulable hypocoagulable states shown to be beneficial patient management. Veterinary Clinical evaluation veterinary medicine is limited; however, recent reports have documented evidence...

Abstract Objective – To evaluate population characteristics, injuries, emergency diagnostic testing, and outcome of dogs with blunt trauma requiring intensive care in an urban hospital. Design Retrospective study 1997–2003. Setting All data obtained from the University Pennsylvania Matthew J. Ryan Veterinary Hospital. Animals Dogs admitted to unit for treatment following trauma. Interventions None. Measurements Main results Of 235 that met inclusion criteria, 206 (88%) survived 29 (12%) did...

The effect of animal-assisted activities (AAA) on the animal participants has been minimally investigated, and welfare these animals questioned. To enhance our understanding animals' welfare, we measured cortisol collected from serial saliva samples 15 healthy adult dogs registered with an AAA organization. We every 30 min before, during, after a standardized 60-min session across three settings: (activity) for college students in communal area residence hall, novel located room without...

While the world awaits a widely available COVID-19 vaccine, availability of testing is limited in many regions and can be further compounded by shortages reagents, prolonged processing time delayed results. One approach to rapid leverage volatile organic compound (VOC) signature SARS-CoV-2 infection. Detection dogs, biological sensor VOCs, were utilized investigate whether positive urine saliva patient samples had unique odor signature. The virus was inactivated all training with either...

To document the clinical, clinicopathologic, and pathologic findings in cats with severe sepsis, identify abnormalities unique to this species, criteria that could be used antemortem diagnose systemic inflammatory response syndrome cats.Retrospective study.29 confirmed have sepsis at necropsy.Pertinent history, physical examination findings, results of hematologic biochemical testing were extracted from medical records.Clinical diagnoses included pyothorax, septic peritonitis, bacteremia...

To determine the effects of nonsteroidal anti-inflammatory drugs various cyclooxygenase selectivities on hemostasis and prostaglandin expression in dogs.8 client-owned dogs with clinical signs osteoarthritis.Dogs received aspirin (5 mg/kg, PO, q 12 h), carprofen (4 24 deracoxib (2 meloxicam (0.1 h) for 10 days each, an interval at least 14 between treatments. On 0 10, blood was collected platelet aggregation assays, thrombelastography, measurement lipopolysaccharide-stimulated E(2),...

Abstract Background: As veterinary medicine has become more sophisticated, with greater numbers of patients receiving intensive care, an acute respiratory distress (ARDS)‐like syndrome have been recognized. Methods: A consensus definition meeting was held for the purpose developing veterinary‐specific definitions lung injury (ALI) and ARDS. Results/conclusions: Three clinically based distress‐like syndromes occurring in were described. Neonatal equine (NERDS) defined separately due to...

To analyze thromboelastograms (TEGs) of naturally occurring cases immune-mediated hemolytic anemia (IMHA) in order to identify whether a hypercoagulable state was present and its presence associated with differences survival.Retrospective study spanning January 2000 June 2008. Medical records dogs were evaluated. Endpoints considered death or discharge from the hospital.Academic teaching hospital.Thirty-nine diagnosis IMHA at least one TEG performed during hospitalization included.None.Four...

All cells release low molecular weight organic compounds that possess finite vapor pressures at body and/or ambient temperatures. These volatile (VOCs) may an odor and can be found emanating from all fluids. As turn malignant, analysis of changes in these VOCs provide insight into cancer onset diagnosis. Previous studies have demonstrated dogs trained to distinguish ovarian tissues various stages grades normal tissue other gynecological malignancies with sensitivity specificity over 95%....

A prospective, nonrandomized study was performed to evaluate the role of endotoxin and tumor necrosis factor (TNF) in dogs with parvoviral enteritis. Seventeen naturally occurring enteritis were enrolled study. Plasma samples obtained for quantification TNF on presentation at 3 6 hours after therapy either fluids prior antibiotics, or concurrently antibiotics. All received standard supportive therapy. Fourteen 17 had their plasma during period; 7 measurable TNF. No detectable from normal...

Abstract Objective: To describe and compare the patient population, treatment, outcome in dogs with septic peritonitis from 2 time periods at same institution. Design: Retrospective study. Setting: The Matthew J. Ryan Veterinary Hospital University of Pennsylvania. Animals: Dogs treated surgically for between 1988–1993 1999–2003. Interventions: None. Measurements: Preoperative physical clinicopathologic data, surgical findings, anesthetic parameters, outcome. Main results: No significant...

To identify hemostatic abnormalities in dogs with protein-losing nephropathies (PLN) that represent risk factors for pathologic thrombosis.Cross-sectional observational study of client-owned PLN, nonprotein losing renal failure (RF), and systemic illness (SI) exclusive primary disease.Urban University Referral Center.A total 29 (n=11 n=7 RF, n=11 SI) were enrolled between January 2001 July 2002. Samples also collected from 20 clinically normal to serve as hemostasis assay controls.None....

One of the proposed mechanisms ventilator-associated lung injury is cyclic recruitment atelectasis. Collapse dependent regions with every breath should lead to large oscillations in PaO2 as shunt varies throughout respiratory cycle. We placed a fluorescence-quenching PO2 probe brachiocephalic artery six anesthetized rabbits after saline lavage. Using pressure-controlled ventilation oxygen, ventilator settings were varied random order over three levels positive end-expiratory pressure (PEEP),...

Objective: To determine the clinical efficacy of abdominal fluid to peripheral blood ratios creatinine and potassium concentrations diagnose uroperitoneum in dogs. Design: Records 13 dogs with confirmed uroabdomen were retrospectively analyzed. Prospective evaluation 8 nonrenal ascites provided data for a control population. Setting: Veterinary Medical Teaching Hospital. Animals: Client owned Interventions: None Measurements Main Results: Abdominal (mEq/L) (mg/dl) recorded. Peripheral also...

To determine whether hyperglycemia is associated with head trauma in dogs and cats the degree of corresponds to severity neurologic injury or outcome.Retrospective study.52 70 122 age- species-matched control cats.Severity was classified as mild, moderate, severe. Blood glucose concentrations recorded within 1 hour after admission were compared between case animals among groups when grouped on basis outcome.Blood concentration significantly higher than animals. However, blood not...

Background:Low‐molecular‐weight heparin (LMWH) has potential benefit in cats at risk for thromboembolic disease. However, LMWH pharmacokinetics not been characterized the cat. Drug effect with may be evaluated analysis of factor Xa inhibition (anti‐Xa) or thromboelastography (TEG). Hypothesis:Administration previously recommended dosages and schedules to healthy will result hypocoagulable TEG. Animals:In vivo research was performed 5 purpose‐bred cats. Methods:In a prospective study...

Volutrauma and atelectrauma have been proposed as mechanisms of ventilator-associated lung injury, but few studies compared their relative importance in mediating injury. The objective our study was to compare the injury produced by stretch (volutrauma) vs. cyclical recruitment (atelectrauma) after surfactant depletion. In saline-lavaged rabbits, we used high tidal volume, low respiratory rate, positive end-expiratory pressure produce nondependent regions dependent regions. Tidal changes...

Background:Low-molecular-weight heparin (LMWH) has potential benefit in cats at risk for thromboembolic disease. However, LMWH pharmacokinetics not been characterized the cat. Drug effect with may be evaluated analysis of factor Xa inhibition (anti-Xa) or thromboelastography (TEG). Hypothesis:Administration previously recommended dosages and schedules to healthy will result hypocoagulable TEG. Animals:In vivo research was performed 5 purpose-bred cats. Methods:In a prospective study...