A5027075534- Respiratory viral infections research
- Influenza Virus Research Studies
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- COVID-19 epidemiological studies
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Antibiotic Use and Resistance
- Healthcare Systems and Technology
- Mycobacterium research and diagnosis
- Lymphoma Diagnosis and Treatment
- Hemoglobin structure and function
- Erythrocyte Function and Pathophysiology
- Infectious Diseases and Mycology
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Neonatal Health and Biochemistry
- Patient Satisfaction in Healthcare
- Toxin Mechanisms and Immunotoxins
- Heparin-Induced Thrombocytopenia and Thrombosis
Madigan Army Medical Center
2000-2009
Texas Oncology
2008
Sarah Cannon
2007-2008
Mary Crowley Cancer Research Center
2008
Duke University
2007
Purpose Generation of broad cytotoxic T-lymphocyte responses against multiple epitopes and tumor-associated antigens (TAAs) may provide effective immunotherapy in patients with cancer. We evaluated a single-vial peptide vaccine consisting nine HLA-A2 supertype-binding (two native seven analog modified for optimal HLA binding or T-cell receptor stimulation) covering five TAAs the universal helper pan-DR epitope, formulated as stable emulsion incomplete Freund's adjuvant (Montanide ISA 51;...
Hemoglobin solutions have several potential advantages as substitutes for erythrocytes transfusion. a prolonged shelf life, are associated with lower risk of transfusion reactions, and provide faster uptake oxygen.1 Hemoglobin-based oxygen carriers (HBOC) been studied primarily in patients hemorrhage, but the absence cell-surface antigens these suggests that they may role treatment autoimmune hemolytic anemias. We report use polymerized bovine hemoglobin, HBOC-201 (Hemopure, Biopure,...
Denileukin diftitox, a chimeric protein, uses the cytocidal properties of diphtheria toxin to cells expressing interleukin-2 receptors. The aim this study was evaluate efficacy and safety denileukin diftitox in treatment advanced relapsed nonsmall cell lung cancer (NSCLC).Multicenter phase II trial patients with NSCLC Eastern Cooperative Oncology Group PS 0-2, stage IIIB/IV at diagnosis, who had failed least 1 previous chemotherapy regimen. infused 18 microg/kg/d x 5 days, every 21 days for...
Abstract Background Households represent important settings for transmission of influenza and other respiratory viruses. Current diagnosis treatment relies upon patient visits to healthcare facilities, which may lead under‐diagnosis delays. This study aimed assess the feasibility an at‐home approach via home testing, telehealth care, rapid antiviral delivery. Methods We conducted a pilot interventional remote in Seattle‐area households with children during 2019‐2020 season using...
Twenty medications are associated with drug-induced organizing pneumonia; however, thalidomide is not listed as a potential causative agent. Thalidomide (Thalomid, Celgene Corp., Summit, NJ), an angiogenesis inhibitor and immunomodulator that reduces tumor necrosis factor-alpha, used for the treatment of multiple myeloma. We report case pneumonia in 58-year-old male myeloma treated dexamethasone thalidomide.
8057 Background: IDM-2101 is a 10-peptide vaccine designed to induce multi-specific CTL responses against MHC class I epitopes of CEA, p53, HER-2/neu and MAGE 2/3. Seven are modified for enhanced binding or heteroclitic T-cell activation 2 native wild-type (WT) sequences. Also included the II helper epitope PADRE. We report here immune clinical activity from Phase trial IDM-2101. Methods: 68 HLA-A2+ good performance patients (pts) with Stage IIIB/IV recurrent NSCLC were enrolled. Patients...
3068 Background: The 10-peptide EP-2101 vaccine is designed to induce multi-specific CTL responses against epitopes in CEA, p53, HER-2/neu and MAGE 2/3. Seven are modified for enhanced MHC binding or heteroclitic T-cell activation including the previously described CAP1–6D analog 2 native wild-type (WT) sequences. Also included helper epitope PADRE. We report here immunogenicity results from a Phase II trial of vaccine. Methods: 66 HLA-A2+ good performance patients with Stage IIIB/IV NSCLC...
Abstract Background Households represent important settings for transmission of influenza and other respiratory viruses. Current diagnosis treatment relies upon patient visits to healthcare facilities, which may lead under-diagnosis delays. This study aimed assess the feasibility an at-home approach via home testing, telehealth care, rapid antiviral delivery. Methods We conducted a pilot interventional remote in Seattle-area households with children during 2019-2020 season using...
Objective: Reducing antibiotic overuse is a point of emphasis the Centers for Disease
 Control and Prevention (CDC). Despite this, both telemedicine traditional in-person
 medical care struggle to meet national guidelines. This study evaluates antibiotic
 prescribing practices at 98point6, Seattle-based provider virtual primary care. This
 paper reviews novel combination machine learning with physician-led virtual
 platform smartphone interface exceed published...