A5102874420- HIV Research and Treatment
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Virology and Viral Diseases
- Glycosylation and Glycoproteins Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- bioluminescence and chemiluminescence research
- Bacteriophages and microbial interactions
- Renal Diseases and Glomerulopathies
- Platelet Disorders and Treatments
- Mast cells and histamine
- Cutaneous Melanoma Detection and Management
- Animal Genetics and Reproduction
- Heparin-Induced Thrombocytopenia and Thrombosis
- Respiratory viral infections research
- Macrophage Migration Inhibitory Factor
- Protein Structure and Dynamics
- Lipid Membrane Structure and Behavior
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Advanced Biosensing Techniques and Applications
- Herpesvirus Infections and Treatments
- Atrial Fibrillation Management and Outcomes
- Xenotransplantation and immune response
Molecular Research Institute
1997
Fairfield Hospital
1994-1996
Monash University
1988-1991
The University of Melbourne
1984-1986
BLZ-100 (tozuleristide) is an intraoperative fluorescent imaging agent that selectively detects malignant tissue and can be used in real time to guide tumor resection. The purpose of this study was assess the safety, tolerability, pharmacokinetics explore pharmacodynamics fluorescence skin tumors. In first-in-human study, administered intravenously 21 adult patients 2 days before excising known or suspected cancers. Doses were 1, 3, 6, 12, 18 mg, with 3–6 patients/cohort. Fluorescence...
Dendritic cells isolated from thymus and tonsil were tested for susceptibility to HIV-1 strains that are tropic macrophages or T cell lines. DCs purified by sorting before infection expressed high levels of CD4 HLA-DR lacked markers T, B, NK cells, macrophages. Viral entry reverse transcription was found after pulsing with could infect During the first 36 h PCR signals gag sequences increased in In contrast little if any viral DNA able pulsed transmit responding during an allogeneic...
Glomerular fibrin deposition and augmentation of procoagulant activity (PCA) are dependent on glomerular macrophage infiltration in anti-glomerular basement membrane antibody-induced glomerulonephritis (anti-GBM GN) rabbits. Expression PCA the surface macrophages and/or intrinsic cell by cytokines (such as IL 1) potential mechanisms which may augment PCA. Macrophages were isolated from glomeruli rabbits developing anti-GBM GN to measure their expression. These characterized morphological...
Myristoylated 21- and 25-residue N-terminal peptides of the Nef protein HIV-1 lysed human erythrocytes were cytotoxic toward a CD4+ T cell line, CEM, primary peripheral blood mononuclear cells (PBMCs). The corresponding nonmyristoylated only very weakly hemolytic cytotoxic. A myristoylated peptide consisting residues 31-50 was neither nor Alteration tryptophan residue at position 13 to serine did not change activity. Studies ultraviolet fluorescence 5 in peptide, using an artificial membrane...
We have found that the hemolytic and cytotoxic activities of myristoylated Nef N-terminal peptides require a net positive charge in first seven amino residues sequence. The are considerably less dependent on secondary structure peptides. Film balance studies showed both active inactive interacted with neutral phospholipid monolayers, suggesting binding to lipids was not sufficient condition for lytic activity. It also nonmyristoylated peptide did interact same extent monolayer, indicating...
Summary Anti-HuPl-ml (reactive with IIIa) and anti-C2G7 the carboxyl terminal of a chain fibrinogen) were used to investigate platelet aggregation, fibrinogen binding thromboxane synthesis induced by low dose collagen (LDC) or high (HDC) in normal aspirin treated platelets. inhibited LDC aggregation almost completely whilst abolishing binding; production although reduced, still occurred. Thus activation was dependent on Gp IIIa. Aggregation platelets HDC anti-HuPl-ml 15-35% association...
TPS9084 Background: BLZ-100 is an intraoperative, fluorescent imaging agent designed to specifically label malignant tissue and enable more complete surgical resection of tumor tissue. achieves targeting through the peptide portion molecule, a modified chlorotoxin (CTX) peptide, its properties from coupled near-infrared dye, indocyanine green. Tumor-specific uptake has been shown in multiple mouse models dogs with spontaneous cancers. Methods: In order characterize safety BLZ-100,...