A5030929271- Nitric Oxide and Endothelin Effects
- Sulfur Compounds in Biology
- Hemoglobin structure and function
- Retinoids in leukemia and cellular processes
- Adenosine and Purinergic Signaling
- Receptor Mechanisms and Signaling
- Chronic Kidney Disease and Diabetes
- Renin-Angiotensin System Studies
- Nuclear Receptors and Signaling
- Pediatric Urology and Nephrology Studies
- Synthesis and Catalytic Reactions
- Smoking Behavior and Cessation
- Dermatology and Skin Diseases
- Renal and related cancers
- Organic and Inorganic Chemical Reactions
- Consumer Attitudes and Food Labeling
- Flavonoids in Medical Research
- TGF-β signaling in diseases
- Pluripotent Stem Cells Research
- Phosphodiesterase function and regulation
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Pharmaceutical studies and practices
- Infective Endocarditis Diagnosis and Management
- Tissue Engineering and Regenerative Medicine
University of Patras
2015-2025
National and Kapodistrian University of Athens
2012-2015
Jena University Hospital
2012
MetaMorph (United States)
2004
University of Washington
2002
Srinakharinwirot University
2002
Baylor College of Medicine
1993-1996
The University of Texas MD Anderson Cancer Center
1996
Matrix Research (United States)
1993
Augusta University
1993
Electronic cigarettes (e-cigs) are advertised as a less harmful nicotine delivery system or new smoking cessation tool. We aimed to assess the in vivo effects of e-cig vapor lung and compare them those cigarette smoke (CS). exposed C57BL/6 mice for either 3 days 4 wk ambient air, CS, containing 1) propylene glycol/vegetable glycerol (PG:VG-Sol; 1:1), 2) PG:VG with (G:VG-N), 3) flavor (PG:VG-N+F) determined oxidative stress, inflammation, pulmonary mechanics. E-cig vapors, especially...
IL-22 is an IL-10 homologue that binds to and signals through the class II cytokine receptor heterodimer IL-22RA1/CRF2-4. produced by T cells induces production of acute-phase reactants in vitro vivo, suggesting its involvement inflammation. Here we report identification a designated IL-22RA2 (IL-22 receptor-alpha 2) appears be naturally expressed soluble receptor. shares amino acid sequence homology with IL-22RA1 (also known as IL-22R, zcytor11, CRF2-9) physically adjacent IL-20Ralpha...
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic (DAergic) neurons in substantia nigra and gradual depletion dopamine (DA). Current treatments replenish DA deficit improve symptoms but induce dyskinesias over time, neuroprotective therapies are nonexistent. Here we report that Nuclear receptor-related 1 (Nurr1):Retinoid X receptor α (RXRα) activation has double therapeutic potential for PD, offering both symptomatic improvement....
Retinoids have been used in the successful treatment of a variety human hyperproliferative diseases. Their role smooth muscle cell (SMC) growth control, however, has not clearly established. The present study was designed to assess retinoid receptor mRNA expression profile SMCs and determine whether retinoids exert growth-inhibitory effect these cells.Five six receptors were expressed both cultured aorta as determined by Northern blotting or reverse transcriptase-polymerase chain reaction....
A murine cardiac specific homeobox gene, Nkx-2.5/CSX, a potential Drosophila tinman homologue, may have fundamental role in myocyte differentiation. DNA binding targets for Nkx-2.5 were recently shown to represent novel homeodomain sequences, some of which resembled serum response elements (SREs); [Chen CY, Schwartz RJ (1995): J Biol Chem 270: 15628–15633]. In this study, facilitated factor (SRF) DNA-binding activity the multiple SREs found on α-actin promoter and together stimulated...
Platelet-derived growth factor (PDGF)-BB is a well-known smooth muscle (SM) cell (SMC) phenotypic modulator that signals by binding to PDGF alphaalpha-, alphabeta-, and betabeta-membrane receptors. PDGF-DD recently identified family member, its role in SMC modulation unknown. Here we demonstrate inhibited expression of multiple genes, including SM alpha-actin myosin heavy chain, upregulated the potent differentiation repressor gene Kruppel-like factor-4 at mRNA protein levels. On basis...
We report the discovery of a Nurr1-RXRα heterodimer-selective rexinoid which emerged from structural modification aminopyrimidine XCT0135908. Although XCT0135908 demonstrated high selectivity for heterodimer over other RXRα dimerization partners, its poor in vivo stability and limited brain penetration hindered utility. Structure–activity relationship (SAR) studies alongside bioactivity evaluations diverse series substituted pyrimidines led to BRF110, brain-penetrant compound retaining...
ABSTRACT. Tubulointerstitial fibrosis is a major characteristic of progressive renal diseases. Platelet-derived growth factor (PDGF) family regulatory molecules consisting PDGF-A and -B, along with the newly discovered PDGF-C -D. They signal through cell membrane receptors, PDGF receptor α (PDGF-Rα) β (PDGF-Rβ). Involvement PDGF-B PDGF-Rβ in initiation progression has been well documented. The authors studied localization ligands receptors by immunohistochemistry, emphasis on role PDGF-D...
ABSTRACT. The PDGF family consists of at least four members, PDGF-A, -B, -C, and -D. All the isoforms bind signal through two known receptors, receptor-α receptor-β, which are constitutively expressed in kidney upregulated specific diseases. It is well established that PDGF-B plays a pivotal role mediation glomerular mesangial cell proliferation. However, little roles recently discovered PDGF-C -D mediating renal injury. In this study, adenovirus constructs encoding PDGF-B, were injected...
In the post-genomic era, rapid evolution of high-throughput genotyping technologies and increased pace production genetic research data are continually prompting development appropriate informatics tools, systems databases as we attempt to cope with flood incoming information. Alongside new that serve enhance connectivity, emerging information should contribute creation a powerful knowledge environment for genotype-to-phenotype in context translational medicine. area pharmacogenomics...
Intense research is conducted to identify new molecular mechanisms of angiogenesis. Previous studies have shown that the angiogenic effects hydrogen sulfide (H<sub>2</sub>S) depend on activation ATP-sensitive potassium channels (K<sub>ATP</sub>) and C-type natriuretic peptide (CNP), which can act through K<sub>ATP</sub>, promotes endothelial cell growth. We therefore investigated whether direct K<sub>ATP</sub> induces responses it required for CNP or vascular growth factor (VEGF). Chick...
The aim of this study was to understand the general public's and healthcare professionals' views on nutrigenomics.We designed a cross-sectional survey professionals (n = 87) public 1504) in three largest cities Greece (Athens, Thessaloniki Patras).Our data revealed that only 11.5% respondents from had been advised take genetic test order explore relationship between their genes nutritional status. Although 80.5% would have willing recommend patients/clients undergo nutrigenomic analysis...
Levels of circulating angiopoietin-2 (Ang-2) increase in sepsis, raising the possibility that Ang-2 acts as a modulator sepsis cascade. To investigate this, experimental was induced male C57BL6 mice by multidrug-resistant isolate <i>Pseudomonas aeruginosa</i>; survival determined along with neutrophil tissue infiltration and release proinflammatory cytokines. Survival significantly increased either pretreatment recombinant 2 h before or treatment 30 min after bacterial challenge. Likewise,...
Inspiratory resistive breathing (RB), encountered in obstructive lung diseases, induces injury. The soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP) pathway is down-regulated chronic and acute animal models of RB, such as asthma, pulmonary disease, endotoxin-induced Our objectives were to: (1) characterize the effects increased concurrent inspiratory expiratory resistance mice via tracheal banding; (2) investigate contribution sGC/cGMP RB-induced Anesthetized C57BL/6...