A5100637810- Flavonoids in Medical Research
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Medicinal Plant Pharmacodynamics Research
- Food Quality and Safety Studies
- Neurological Disease Mechanisms and Treatments
- Chromatography in Natural Products
- Saffron Plant Research Studies
- Drug-Induced Hepatotoxicity and Protection
- Polysaccharides and Plant Cell Walls
- Traditional Chinese Medicine Studies
- Silymarin and Mushroom Poisoning
- Radiomics and Machine Learning in Medical Imaging
- Natural Compound Pharmacology Studies
- Geochemistry and Geologic Mapping
- S100 Proteins and Annexins
- Spectroscopy and Chemometric Analyses
- Plant-Derived Bioactive Compounds
- Fungal Biology and Applications
- Polysaccharides Composition and Applications
- Thyroid Cancer Diagnosis and Treatment
- Industrial Engineering and Technologies
- Ginseng Biological Effects and Applications
Jiangxi University of Traditional Chinese Medicine
2009-2024
Chengdu University of Traditional Chinese Medicine
2006-2021
First People's Hospital of Foshan
2010-2012
The dry root of Scutellaria baicalensis, has traditionally been applied in the treatment cerebral ischemia Chinese clinics. Baicalin (BA) is considered key ingredient it for brain protection effects. bioavailability BA very low because its poor lipid and water solubility, which limits therapeutic effects clinical application. aim present study was to develop a novel BA-loaded liposome (BA-LP) formulation improve drug lipophilicity further enhance drug-concentration tissues. This also...
To improve the dissolution and bioavailability of poorly soluble drugs, novel nanosuspensions using co-processed nanocrystalline cellulose-sodium carboxymethyl starch (NCCS) as a synergetic stabilizer were first designed.Co-processed NCCS was prepared by means homogenization. Poorly baicalin (BCA) used model drug. BCA nanosuspension (BCA-NS/NCCS) dispersant via homogenization further converted into dried particle (BCA-NP/NCCS) spray drying. The influence on dispersion efficiency BCA-NS/NCCS...
The aim of this study was to prepare ursodeoxycholic acid–phospholipid complex (UDCA-PLC) enhance oral bioavailability UDCA, and the physicochemical properties were studied. Compared with those UDCA tablet after administration in rats, main pharmacokinetic characteristics UDCA-PLC orally administered evaluated. Tetrahydrofuran used as a reaction medium, phospholipids resolved into formed organic solvent evaporated off under vacuum condition. evaluated using scanning electron microscopy...
Abstract Herb processing is a typical pharmaceutical preparation process for traditional Chinese medicine. After processing, its clinical applications and pharmacological effects vary greatly, which most commonly attributed to the changing chemical properties between raw herb processed products. In this work, total of 53 compounds were detected, among 17 identified as discriminatory chemicals wine‐processed Scutellaria baicalensis , 10 components markers with cumulative content contribution...
A support vector regression (SVR) method was introduced to improve the robustness and predictability of design space in implementation quality by (QbD), taking extraction process Pueraria lobata as a case study. In this paper, time, number cycles, liquid⁻solid ratio were identified critical parameters (CPPs), yield puerarin, total isoflavonoids, extracta sicca attributes (CQAs). Models between CQAs CPPs constructed using both conventional quadratic polynomial model (QPM) SVR algorithm. The...
Baicalin, a flavonoid glycoside compound present in Scutellaria baicalensis, has shown wide spectrum of biological activities, but its liposolubility, water-solubility and mucosal permeability are all very poor, which leads to the low concentration brain poor bioavailability by oral or intravenous injective administration.The primary objective this study was formulate baicalensis extract (SBE) with phospholipid yield extract-phospholipid complex (SBEPC) , evaluate pharmacodynamics middle...
Addressing the enduring challenge of evaluating traditional Chinese medicines (TCMs), integrated evidence chain-based effectiveness evaluation TCMs (Eff-iEC) has emerged. This paper explored its capacity through a demonstration study that evaluated six commonly used anti-hepatic fibrosis patent (CPMs), including Biejiajian Pill (BP), Dahuang Zhechong (DZP), Biejia Ruangan Compound (BRC), Fuzheng Huayu Capsule (FHC), Anluo Huaxian (AHP), and Heluo Shugan (HSC), using both Eff-iEC Grading...