A5026506345- Hepatitis C virus research
- Hepatitis B Virus Studies
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Pharmacological Effects of Natural Compounds
- Drug Transport and Resistance Mechanisms
- Veterinary medicine and infectious diseases
- Salmonella and Campylobacter epidemiology
- Antibiotic Resistance in Bacteria
- HIV/AIDS drug development and treatment
- Immunotherapy and Immune Responses
- Pharmacogenetics and Drug Metabolism
- Hepatitis Viruses Studies and Epidemiology
- Viral Infections and Vectors
- Atmospheric and Environmental Gas Dynamics
- Neonatal Health and Biochemistry
- Genetic Syndromes and Imprinting
- Liver Diseases and Immunity
- Methemoglobinemia and Tumor Lysis Syndrome
- Phytochemistry and biological activity of medicinal plants
- Poisoning and overdose treatments
- Biomedical Research and Pathophysiology
- Healthcare Systems and Reforms
- Renal and related cancers
Peking University First Hospital
2012-2022
Peking University
2012-2022
Peking University International Hospital
2017-2022
Yantai Infectious Diseases Hospital
2020
First Hospital of Qinhuangdao
2020
Aerospace Center Hospital
2020
Wuxi Fourth People's Hospital
2020
Second Affiliated Hospital of Guangzhou Medical University
2020
Guangzhou Medical University
2020
Beijing YouAn Hospital
2018
To investigate the dynamic development of antimicrobial resistance Campylobacter jejuni isolated from human diarrhea in Beijing, China, between 1994 and 2010, to further analyze molecular mechanisms erythromycin-resistant strains.Susceptibility tests were performed on 203 non-duplicate clinical C. strains against eight common antibiotics using standard agar dilution method. The determinants studied erythromycin (ERY) non-susceptible strains. analysis focused 23S rRNA gene, rplD rplV...
A recent study revealed that quantitative hepatitis B core antibody (qAnti-HBc) level could serve as a novel marker for predicting treatment response. In the present study, we further investigated predictive value of qAnti-HBc in HBeAg-positive patients undergoing PEG-IFN therapy. total 140 who underwent therapy 48 weeks and follow-up 24 were enrolled this study. Serum samples taken every 12 post-treatment. The baseline response was evaluated. Patients divided into 2 groups according to...
Abstract Background The aim of this study was to evaluate the management acute adult diarrhea in China and assess adherence clinical practice national guidelines 2012 World Gastroenterology Organization guidelines. Methods A cross-sectional survey carried out among physicians 20 hospitals two different areas (Beijing, 10; Shaanxi province, 10). Summary statistics were calculated for overall group each region. Between-region differences assessed with χ 2 or t -tests. Results Data collected...
We assessed the susceptibility of 182 Campylobacter jejuni isolates from patients with diarrhea to eight antibiotics and analyzed molecular mechanisms ciprofloxacin resistance as well genetic characteristics based on multilocus sequence typing (MLST). The C257T mutation was found quinolone resistance-determining region (QRDR) gyrA gene in all ciprofloxacin-resistant strains. Mutations QRDR gyrB were silent. A total 74 strains had 7 inverted repeat (IR) (a 16-bp IR intergenic between cmeR...
BACKGROUNDPolygonum multiflorum is one of the leading causes herb-induced liver injury in China.HLA-B*35:01 reported to be a potential biomarker Polygonum multiflorum-induced (PM-DILI).However, little known about relationship between single-nucleotide polymorphisms (SNPs) and PM-DILI. AIMTo identify SNPs that indicate susceptibility METHODSWe conducted systematic study enrolling 382 participants from four independent hospitals, including 73 PM-DILI patients, 118 patients with other
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease manifested with the aberrant activation of hepatic dendritic cells (HDCs) and subsequent breakdown immune homeostasis. As an important player, HDC maintains immunological balance between tolerance to self-antigens versus destruction against pathogens in liver. However, intracellular signalling networks that program remain unclear. We have now found role canonical Wnt/β-catenin HDCs.Liver sections from AIH patients healthy...
Background: Campylobacter jejuni infection, traditionally a paediatric illness, is now seen more frequently in adolescents and adults northern China. Published surveillance reports on C. infection these patients are rare. We aimed to characterize (1) the clinical manifestations of this adults, (2) changes antibiotic resistance pathogen. Methods: retrospectively examined 492 cases aged ≥ 14 y treated at Peking University First Hospital, Beijing, China, for period January 1994 December 2010....
The dynamics of programmed death-1 (PD-1) as well cytokine/chemokine expression and its correlation with virological response in patients chronic hepatitis B (CHB) is unclear. This study was conducted 29 treatment-naïve undergoing telbivudine treatment for 52 weeks. results showed that PD-1 on both CD4+ CD8+ T cells positively correlated virus (HBV) DNA levels (r = 0.621, P < 0.0001; r 0.548, 0.002, respectively), responders, this decrease directly a HBV 0.664, 0.002; 0.572, 0.01,...
Background & Aims About 350–400 million people are infected with hepatitis B virus (HBV) chronically and 1 die of (HBV)-related liver diseases. Nucleos(t)ide analogues (NAs) have been used for the treatment against HBV. However, few studies investigated long-term effects different nucleos(t)ide on levels surface antigen (HBsAg) in patients chronic (CHB). The aims this study were to measure magnitude HBsAg reduction by monotherapy adefovir dipivoxil (ADV) entecavir (ETV), compare between two...
Objective: To investigate the clinical effect and safety of long-acting pegylated interferon-α-2b (Peg-IFN-α-2b) (Y shape, 40 kD) injection (180 μg/week) in treatment HBeAg-positive chronic hepatitis B (CHB) patients, with standard-dose Peg-IFN-α-2a as positive control. Methods: This study was a multicenter, randomized, open-label, positive-controlled phase III trial. Eligible CHB patients were screened out randomized to Peg-IFN-α-2b trial group control at ratio 2:1. The course 48 weeks...
Background Few models to predict antiviral response of peginterferon were used in hepatitis B e antigen (HBeAg)-positive chronic patients and the prediction efficacy was unsatisfied. Quantitative antibody core (anti-HBc) is a new predictor treatment response. We aimed develop model identify HBeAg-positive Chinese who more likely respond peginterferon. Methods Data from 140 recipients with applied generalized additive multiple logistic regression analysis baseline scoring system serological...
Background Knowledge on Hepatitis B surface antigen (HBsAg) kinetics in chronic hepatitis (CHB) patients with long-term adefovir dipivoxil (ADV) treatment is limited. The aims of this study were to investigate HBsAg virus (HBV) infection treated ADV and evaluate different characteristics between without loss. Methods We retrospectively evaluated 24 Chinese HBV who achieved continuous virologic suppression during therapy. genotype was determined at baseline. Liver biochemistry, e status,...
This case highlights a patient with Gilbert syndrome who underwent endoscopic retrograde cholangiopancreatography (ERCP) removal of bile duct stones, then experienced an unexplained increase in bilirubin, total bilirubin (TBIL) levels increasing from 159.5 μmol/L to 396.2 and maximum 502.8 after 9 d. Following the decrease TBIL level, enhanced magnetic resonance (MRCP) was performed exclude any possible remaining choledocholithiasis. Nevertheless, serum level increased again, rising 455.7...
Chronic hepatitis B demographics and comorbidity data are limited in China. Materials & methods: The China Health Insurance Association claims database from 2013 2016 was used to augment the existing data: proportion of patients aged >45 years increased significantly 40.3% 49% (p < 0.001). Results: Significant increases multiple comorbidities were observed, including hypertension (9.4–14.5%), hyperlipidemia (4.7–7.0%) cardiovascular disease (5.7–10%; p 0.001 for all comparisons)....
Abstract Rationale: Ciliopathies is a group of clinically and genetically overlapping disorders due to cilia abnormalities multiple organ systems are involved in. Patient concerns: We present young female patient who showed renal function impairment, Caroli syndrome (CS), liver cirrhosis, polycystic ovarian syndrome, subcutaneous cysts. Diagnoses: The was diagnosed with ciliopathy according the clinical manifestations whole-genome sequencing. Interventions: She received treatment intravenous...
The differences between Chinese herbal medicine (CHM)- and Western (WM)-induced liver injury have rarely been reported. Our aim was to investigate the clinical features of patients with drug-induced (DILI) caused by CHM or WM. medical records 726 DILI were retrospectively collected at Peking University First Hospital from January 1995 through August 2019. number inpatients in our hospital showed an increasing trend over time. incidence exhibited a linear toward increase time (P = .0012). Of...