A5100327413- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Pharmacological Effects of Natural Compounds
- Gastroesophageal reflux and treatments
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet, Metabolism, and Disease
- Radiomics and Machine Learning in Medical Imaging
- Alcohol Consumption and Health Effects
- Solar Thermal and Photovoltaic Systems
- Hepatitis Viruses Studies and Epidemiology
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Medicinal Plant Pharmacodynamics Research
- Atherosclerosis and Cardiovascular Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Solar-Powered Water Purification Methods
- Enzyme Structure and Function
- Amino Acid Enzymes and Metabolism
- Regulation of Appetite and Obesity
- Metabolism and Genetic Disorders
- Biochemical and Molecular Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Environmental and Agricultural Sciences
Hebei Medical University
2024
Shandong University of Traditional Chinese Medicine
2024
Fifth Hospital of Shijiazhuang
2024
Jiangnan University
2018-2023
Shanghai University of Traditional Chinese Medicine
2016-2022
Nanjing Medical University
2020
Anhui University of Traditional Chinese Medicine
2020
Beijing YouAn Hospital
2020
First Affiliated Hospital of Xi'an Jiaotong University
2020
Huai'an City Fourth People's Hospital
2017-2020
Oncostatin M (OSM) is a secreted cytokine mainly involved in chronic inflammatory and cardiovascular diseases through binding to OSM receptor β (OSMR-β). Recent studies demonstrated that the presence of contributed destabilization atherosclerotic plaque. To investigate whether OSMR-β deficiency affects atherosclerosis, male OSMR-β−/−ApoE−/− mice were generated utilized. Here we observed expression was remarkably upregulated both human mouse lesions, which located macrophages. We found...
Glycyrrhizin (GA) analogs in the form of 3-glucuronides and 18-epimers were synthesized their anticancer activities evaluated. Alkaline isomerization monoglucuronides is reported. In vitro vivo studies showed that glycyrrhetinic acid (GAMGs) displayed higher than those bisglucuronide GA analogs, while activity 18α-epimer was superior to 18β-epimer. 18α-GAMG firstly nicely bound epidermal growth factor receptor (EGFR) via six hydrogen bonds one charge interaction, docking calculation proved...
The gut microbiota is involved in the occurrence and development of chronic liver diseases. Zonulin considered a marker intestinal permeability. purpose this study was to assess zonulin levels patients with hepatitis B (CHB), HBV-associated cirrhosis (LC), hepatocellular carcinoma (HCC). population consisted 90 HCC patients, LC CHB healthy subjects. Serum AFP were determined. diagnostic accuracy each evaluated using receiver operating characteristic (ROC) curve analysis (AUC). significantly...
Objective Recent evidence has revealed that the aspartate aminotransferase to alanine ratio (AST/ALT ratio) may be closely associated with metabolic syndrome and insulin resistance. However, it is unclear whether AST/ALT correlates prediabetes risk. The aim of our study was examine association between ratios risk among a large cohort Chinese subjects. Methods This retrospective recruited 75204 adults normoglycemia at baseline who underwent physical examinations Rich Healthcare Group from...
Abstract Hepatocellular carcinoma (HCC) remains the most common malignant tumor worldwide. Long noncoding RNAs can modulate various tumorigenic processes. In addition, growing evidence has indicated tha Janus kinase–signal transducer and activator of transcription (JAK‐STAT) pathway is activated in multiple cancers, including HCC. Recently, it was found that LINC00346 participate several cancers. Nevertheless, biological roles HCC have been barely investigated. this study, function...
Breast cancer is the most common malignant tumor in women. Its incidence associated with obesity and metabolic syndrome (MetS), which are highly prevalent world widely have been identified as poorer prognosis factors breast including triple-negative (TNBC), has response to chemotherapy, radiotherapy, endocrine therapy. Programmed death ligand 1 (PD-L1) one of immune checkpoints ligands that facilitates escape progress. Obesity/MetS could cause systemic inflammation disorders, however,...
China is a highly endemic area of chronic hepatitis B (CHB). The accuracy existed noninvasive biomarkers including TE, APRI and FIB-4 for staging fibrosis not high enough in Chinese cohort.Using liver biopsy as gold standard, novel indicator was developed using laboratory tests, ultrasound measurements stiffness with machine learning techniques to predict significant cirrhosis CHB patients north east part China. We retrospectively evaluated the diagnostic performance named FibroBox,...
Adamantane and oseltamivir resistance among influenza viruses is a major concern to public health officials. To determine the prevalence of antiviral-resistant in Guangdong, China, 244 seasonal A (H1N1) 222 pandemic 2009 were screened for by fluorescence-based neuraminidase (NA) inhibition assay along with NA gene sequencing. Also, 147 sequenced detect adamantane markers M2. Adamantane-resistant clustering clade 2C dominant 2008, followed oseltamivir-resistant viruses, 2B during January May...
Aim . To compare the clinical efficacy of combination therapy with Bushen formula (BSF) plus entecavir (ETV) in naïve chronic hepatitis B (CHB) patients and that CHB partial virological response to ETV explore relevant immunoregulatory mechanism. Materials Methods Two hundred twenty were enrolled historical prospective cohort study. Patients categorized into a treatment group (T-Group: BSF ETV) control (C-Group: ETV). T-Group C-Group grouped T1/C1 (treatment-naïve patients) T2/C2 (patients...
Objective . To evaluate the impact of long‐term Traditional Chinese Medicine (TCM) syndrome differentiation combined with antiviral therapy Nucleos (t) ide analogues (NAs) on incidence cirrhosis in patients chronic hepatitis B. Methods This retrospective cohort study included 521 B who underwent a treatment course ≥3 years from 1998–2019. Of patients, 261 were defined as TCM users while 260 nonusers (control group). All enrolled subjects followed up until February 2019 to measure and hazard...
To evaluate the efficacy and safety of telbivudine in chronic hepatitis B women during second third trimesters pregnancy. The week 12–34 pregnant were screened this prospective non-intervention study, with HBV DNA > 106 IU/mL alanine aminotransferase 50 IU/L. patients received treatment as a group or without antiviral control group. All infants recombinant vaccine 10 μg within 12 h birth, at 4 24, immunoglobulin G birth detected markers range from 7 to months after delivery. A total 241...
Background Observational studies have suggested a potential association between abdominal viscera volume and increased risk of stroke. However, the causal relationship remains unclear. This study aims to utilize Mendelian randomization (MR) explore genetic them. Methods We conducted MR analysis effects five volumes on The variations were obtained from UK Biobank, summary data for stroke ischemic acquired MEGASTROKE consortium. employed inverse variance weighting (IVW), Egger, weighted median...
Bushen Jianpi formula (BSJPF, also known as Lingmao formula) is a traditional Chinese medicine for chronic hepatitis B (CHB). The previous study has suggested that the treatment combination of BSJPF and entecavir (ETV) can achieve significant loss e antigen (HBeAg) decrease in serum level virus (HBV) DNA HBeAg-positive CHB patients with mildly elevated alanine aminotransferase.This aimed to evaluate efficacy safety combined ETV treating HBeAg-negative patients.A total 640 were assigned...