A5017974060- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- SARS-CoV-2 detection and testing
- Telomeres, Telomerase, and Senescence
- Anodic Oxide Films and Nanostructures
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Genetics, Aging, and Longevity in Model Organisms
- Sperm and Testicular Function
- Advanced Nanomaterials in Catalysis
- Microfluidic and Bio-sensing Technologies
- Cell Adhesion Molecules Research
- Muscle Physiology and Disorders
- Nanopore and Nanochannel Transport Studies
- Luminescence and Fluorescent Materials
- RNA Research and Splicing
ShenZhen People’s Hospital
2023
Nanjing University
2019-2021
Guangdong Medical College
2020
BGI Group (China)
2014
Shaanxi Normal University
2010
Glioblastoma (GBM) is one of the most fatal tumors in brain, and its early diagnosis remains technically challenging due to complex repertoires oncogenic alterations blood-brain barrier (BBB). GBM-derived specific exosomes can cross BBB circulate body fluids, so they be noninvasive biomarkers for GBM. Herein, we propose a sensitive label-free electrochemical biosensor designed by using Zr-based metal–organic frameworks (Zr-MOFs) detection with practical application. In design, peptide ligand...
The exosome is a promising biomarker carrying many kinds of membrane proteins with huge heterogeneity, so the sensitive and multiplex analysis exosomes very significant for disease diagnosis exploration their biological functions. Herein, we propose an efficient method highly detection heterogeneity identification based on design fabrication aptamer-coated liposome complex coupled terminal deoxynucleotidyl transferase (TdT)-mediated polymerization. Specifically, in presence target exosomes,...
A simple and sensitive method for exosome detection based on steric hindrance-controlled signal amplification.
The development of a simple, sensitive, and effective method for the analysis circulating tumor cells (CTCs) is essential cancer diagnosis metastasis prediction. In this work, we have proposed an enzyme-free electrochemical specific capture, sensitive quantification, efficient release CTCs. To achieve this, interaction between CTCs corresponding aptamer designed to be located in identification probe (IP) will unfold hairpin structure IP. Consequently, IP initiate hybridization reaction...
Background . Exosomes exist in almost all body fluid and contain diverse biological contents which may be reflective of disease state. Circular RNAs (circRNAs) are stable structure have a long half-life exosomes without degradation, thus making them reliable biomarkers. However, the potential exosomal circRNAs as biomarkers coronary artery (CAD) remains to established. Here, we aimed investigate expression levels use diagnostic for CAD. Methods CircRNA obtained from three plasma samples CAD...
Mutations in the LAMA2 gene cause laminin α‑2 (merosin)‑deficient congenital muscular dystrophies, which are autosomal recessive muscle disorders. Laminin is widely expressed basement membrane of skeletal muscle, myotendinous junctions and extra‑synaptically at neuromuscular synapses. In present study, target next‑generation sequencing was used for mutation detection, polymerase chain reaction (PCR) analysis Sanger were identification small deletions. Subsequently, quantitative PCR (qPCR)...
We have proposed a simple electrochemical method in this work for the assay of tumor cells through their own steric hindrance effect.