A5077380948- Pain Mechanisms and Treatments
- Ion Channels and Receptors
- Neuropeptides and Animal Physiology
- Connexins and lens biology
- Neuroendocrine regulation and behavior
- Nerve injury and regeneration
- Acupuncture Treatment Research Studies
- Receptor Mechanisms and Signaling
- Pain Management and Placebo Effect
- Respiratory and Cough-Related Research
Shanghai Medical College of Fudan University
2024
State Key Laboratory of Medical Neurobiology
2019-2020
Fudan University
2019-2020
Chinese Institute for Brain Research
2020
Abstract Trigeminal neuralgia (TN) is debilitating and usually accompanied by mood disorders. The lateral habenula (LHb) considered to be involved in the modulation of pain disorders, present study aimed determine if how LHb participates development anxiety TN. To address this issue, a mouse model partial transection infraorbital nerve (pT-ION) was established. pT-ION induced stable long-lasting primary secondary orofacial allodynia anxiety-like behaviors that correlated with increased...
Persistent pain frequently precipitates the development of anxiety disorders, yet underlying mechanisms are not fully understood. In this study, we employed a mouse model that simulates trigeminal neuralgia and observed marked reduction in activity GABAergic neurons lateral habenula (LHb), critical region for modulating anxiety. We utilized precise optogenetic chemogenetic techniques to modulate these neurons, which significantly alleviated behaviors associated with Our investigations...