A5060585083- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Diagnosis and treatment of tuberculosis
- COVID-19 and Mental Health
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Resistance in Bacteria
- Infectious Diseases and Tuberculosis
- Plant Molecular Biology Research
- Multiple Sclerosis Research Studies
- Family Support in Illness
- Plant Stress Responses and Tolerance
- Obesity, Physical Activity, Diet
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Cardiovascular Health and Risk Factors
- Cancer survivorship and care
- Posttraumatic Stress Disorder Research
- Medical Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Optimism, Hope, and Well-being
- Bacterial Identification and Susceptibility Testing
- Air Quality and Health Impacts
- Plant Reproductive Biology
- Infectious Diseases and Mycology
- Nutritional Studies and Diet
Sichuan University
2017-2025
Chinese Center For Disease Control and Prevention
2015-2025
Fujian Agriculture and Forestry University
2020-2025
Ministry of Agriculture and Rural Affairs
2024-2025
National Cancer Center
2025
Shanghai University of Medicine and Health Sciences
2025
Center for Disease Control
2012-2024
Center for Tuberculosis Control of Guangdong Province
2013-2024
National Cancer Center
2024
Nankai University
2021-2023
The available information on the epidemic of drug-resistant tuberculosis in China is based local or regional surveys. In 2007, we carried out a national survey China.
Phenotypic and phylogenetic studies were performed on 15 isolates of an unidentified Gram-positive, anaerobic, non-sporulating coccobacillus-shaped bacterium isolated from human faeces. The novel organisms catalase-negative, indole-negative produced acetate succinate as end products metabolism. Comparative 16S rRNA gene sequencing demonstrated that the highly related to each other formed a hitherto unknown subline within clostridial cluster XIVa. robust group with number which included...
Abstract MicroRNAs (miRNAs) are small noncoding RNAs that play a vital role in plant responses to abiotic and biotic stresses. Recently, it has been discovered some primary miRNAs (pri‐miRNAs) encode regulatory short peptides called miPEPs. However, the presence of miPEPs rice, their functions response stresses, particularly stress induced by heavy metals, remain poorly understood. Here, we identified functional peptide (miPEP156e) encoded pri‐miR156e regulates expression miR156 its target...
Background Tuberculosis (TB), caused by Mycobacterium tuberculosis complex (MTBC), is one of the major causes death in world today. Although China has second largest global case rate tuberculosis, a systematic study TB prevalence not been completed. From 2006 to 2007, base line surveillance was carried out Ministry Health, and more than 4000 representative strains were selected from 31 provinces China. Methodology/Principal Findings The aim present research survey genotypes (M. tuberculosis)...
Rifampin (RIF) susceptibility is a key factor in determining the treatment effectiveness of standardized regimens. In Mycobacterium tuberculosis, both target gene mutation and efflux pump play major roles resistance to antituberculosis drugs. By eliminating RIF-resistant strains with rpoB mutation, choice RIF-monoresistant may allow us identify RIF-specific genes. This study explored RIF monoresistance mechanism M. tuberculosis. Data from DNA sequencing MIC measurements revealed that...
To explore the status quo and influencing factors of residents' knowledge, attitude practice (KAP) in prevention control coronavirus disease 2019 (COVID-19), difficulties or challenges perceived by residents their preventive practice.
China, with the third largest share of global tuberculosis cases, faces a substantial challenge in its healthcare system as result high burden multidrug-resistant and rifampicin-resistant (MDR/RR-TB). This study employs genomic epidemiological approach to assess recent transmissions between individuals, identifying potential risk factors discerning role transmitted resistant isolates emergence drug-resistant China.
The main goal of our study was to evaluate the in vitro bedaquiline susceptibility six prevalent species pathogenic nontuberculous mycobacteria (NTM) China. In addition, we investigated potential molecular mechanisms contributing resistance different NTM species. Among slowly growing (SGM), exhibited highest activity against Mycobacterium avium; MIC50 and MIC90 values were 0.03 16 mg/liter, respectively. rapidly (RGM), abscessus subsp. (M. abscessus) massiliense massiliense) seemed more...
Background. Multiple sclerosis (MS) has become a disease that represents tremendous burden on patients, families, and societies. The exact etiology of MS is still unclear, but it believed combination genetic environmental factors contribute to this disease. Although some meta-analyses the association between smoking have been previously published, number new studies with larger population data published since then. Consequently, these additional critical articles need be taken into...
Objectives The present study aimed to investigate the prevalence of central obesity among adults with normal BMI and its association metabolic diseases in Jilin Province, China. Methods A population-based cross-sectional was conducted 2012 Province Information collected by face interview. Descriptive data analysis 95% confidence intervals (CI) prevalence/frequency were conducted. Log-binomial regression analyses used find independent factors associated explore adjusted between BMI. Results...
Background Early and effective detection of Mycobacterium tuberculosis (MTB), particularly in smear-negative (TB), is a priority for global TB control. Loop-mediated isothermal amplification with procedure ultra rapid DNA extraction (PURE-LAMP) can detect sputum samples rapidly high sensitivity specificity. However, the PURE-LAMP test has not been effectively evaluated, especially resource-limited laboratories. In this study, we evaluated performance suspects from two county-level...
Objectives This study aims to estimate the prevalence of overweight and obesity determine potential influencing factors among adults in northeast China. Methods A cross-sectional survey was conducted Jilin Province, China, 2012. total 9873 men 10 966 women aged 18–79 years from general population were included using a multistage stratified random cluster sampling design. Data obtained face-to-face interview physical examination. After being weighted according complex scheme, sample used...
ABSTRACT Drug-resistant tuberculosis (TB), especially multidrug-resistant TB (MDR-TB), is still one of the most serious threats to control worldwide. Early diagnosis MDR-TB important for effectively blocking transmission and establishing an effective protocol chemotherapy. Genechip a rapid diagnostic method based on molecular biology that overcomes poor biosafety, time consumption, other drawbacks traditional drug sensitivity testing (DST) can detect MDR-TB. However, approach has not been...
Introduction A new class of Mycobacterium tuberculosis (MTB) antigen-based skin tests was recommended by WHO for the diagnosis TB infection. However, their performance in some settings remains suboptimal. Our study focused on screening novel MTB recombinant antigens and evaluating preclinical efficacy infection detection. Methods We constructed Escherichia coli BL21 expression vectors to produce a series antigens. assessed ability detect through tests. Model animals sensitized with BCG were...
Early-onset idiopathic scoliosis (EOIS) is a spinal deformity that develops before the age of 10 years with unknown etiology. Scoliosis can lead to respiratory muscle weakness and decreased motor function. Nevertheless, effects mild EOIS on pulmonary function functional exercise capacity remain poorly understood. Early detection crucial mitigate its impact children's health prevent progression. The aim this study was investigate characteristics in children identify influencing factors. 52...