A5034988033- Reproductive Biology and Fertility
- Reproductive Health and Technologies
- Pluripotent Stem Cells Research
- Menstrual Health and Disorders
- Electrospun Nanofibers in Biomedical Applications
- Telomeres, Telomerase, and Senescence
- Cancer Immunotherapy and Biomarkers
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Assisted Reproductive Technology and Twin Pregnancy
- Gut microbiota and health
- Ovarian function and disorders
- Pelvic floor disorders treatments
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Single-cell and spatial transcriptomics
- Biochemical effects in animals
- Reproductive tract infections research
- Circular RNAs in diseases
Huazhong University of Science and Technology
2022-2024
Tongji Hospital
2022-2024
National Clinical Research Center for Digestive Diseases
2022-2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Ministry of Education of the People's Republic of China
2022
Abstract STUDY QUESTION What is the current burden of infertility attributable to PCOS at global, regional, and national levels by age socio-demographic index (SDI) across 21 regions 204 countries territories? SUMMARY ANSWER The increased from 6.00 million prevalent cases in 1990 12.13 2019 globally sharply most nations. WHAT IS KNOWN ALREADY common cause anovulatory infertility, affecting up 80% women with anovulation. No comprehensive detailed epidemiological estimates reproductive aged...
Ovarian damage induced by platinum-based chemotherapy seriously affects young women with cancer, manifesting as infertility, early menopause, and premature ovarian insufficiency. However, effective prevention strategies for such are lacking. Senescent cells may be chemotherapeutic agents. We hypothesized that cisplatin can lead to senescence in during the therapeutic process, senolytic drugs protect animals against cisplatin-induced injury. Here, we demonstrated existence of senescent...
Abstract STUDY QUESTION What is the burden of premenstrual syndrome (PMS) at global, regional, and national levels across 21 regions 204 countries territories? SUMMARY ANSWER Over past few decades, global prevalent cases PMS have grown significantly from 652.5 million in 1990 to 956.0 2019, representing a 46.5% increase. WHAT IS KNOWN ALREADY PMS, which affects almost half reproductive women worldwide, has substantial social, occupational, academic, psychological effects on women’s lives....
ABSTRACT Vaginitis is the most common problem afflicting women of childbearing age. However, underlying etiological factors remain poorly understood, leading to recurrent vaginitis and constraining clinical management. Here, we explored whether gut microbiota influences risk by performing a two-sample Mendelian randomization analysis using largest genome-wide association studies date. Four taxa in genus levels were identified related vaginitis: Candidatus Soleaferrea (inverse-variance...
Would the construction of a competing endogenous RNA (ceRNA) network help identify new drug targets for development potential therapies polycystic ovary syndrome (PCOS)?Both Food and Drug Administartion (FDA)-approved candidate drugs could be identified by combining bioinformatics approaches with clinical sample analysis based on our established ceRNA network.Thus far, no effective are available treating PCOS. ceRNAs play crucial roles in multiple diseases, some them current use as...