A5013874680- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Immune cells in cancer
- Barrier Structure and Function Studies
- MicroRNA in disease regulation
- Nerve injury and regeneration
- Immune Response and Inflammation
- Neurological disorders and treatments
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
- Computational Drug Discovery Methods
- Cellular Mechanics and Interactions
- Neurological diseases and metabolism
- Organometallic Complex Synthesis and Catalysis
- NF-κB Signaling Pathways
- Enzyme Structure and Function
- Signaling Pathways in Disease
- Spinal Cord Injury Research
- Multiple Sclerosis Research Studies
- Chemical Synthesis and Reactions
- Traumatic Brain Injury and Neurovascular Disturbances
- Phytochemical Studies and Bioactivities
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
Second Military Medical University
2009-2022
Huazhong Agricultural University
2019
The regulation of inflammation is pivotal for preventing the development or reoccurrence multiple sclerosis (MS). A biased ratio high-M1 versus low-M2 polarized microglia a major pathological feature MS Here, using microarray screening, we identify long noncoding RNA (lncRNA) GAS5 as an epigenetic regulator microglial polarization. Gain- and loss-of-function studies reveal that suppresses M2 Interference with in transplanted attenuates progression experimental autoimmune encephalomyelitis...
Background The pathology of Parkinson's disease (PD) is characterized by the degeneration nigrostriatal dopaminergic pathway, as well formation intraneuronal inclusions known Lewy bodies and neurites in substantia nigra. Accumulations nitrated α-synuclein are demonstrated signature disease. However, whether nitration relevant to pathogenesis PD unknown. Methodology/Principal Findings In this study, effect (DA) neurons was determined delivering recombinant TAT-α-synuclein intracellular. We...
The major challenge for progressive multiple sclerosis therapy is the promotion of remyelination from inflammation-induced demyelination. A switch an M1- to M2-dominant polarization microglia critical in these repair processes. In this study, we identified homeobox gene msh-like homeobox-3 ( Msx3 ) as a new pivotal regulator microglial polarization. MSX3 was induced during M2 and repressed M1 cells. expression dynamically regulated experimental autoimmune encephalomyelitis (EAE), which...
Blood-brain barrier (BBB) impairment is an early prevalent feature of multiple sclerosis (MS), and remains vital for MS progression. Microglial activation precedes BBB disruption cellular infiltrates in the brain patients. However, little known about function microglia impairment. Here, acts as important modulator integrity inflammatory demyelination. depletion profoundly ameliorates experimental autoimmune encephalomyelitis (EAE). Specifically, miR-126a-5p positively correlated with four...
Macrophages in the brain barrier system include microglia parenchyma, border-associated macrophages at brain's borders, and recruited macrophages. They are responsible for neural development, maintenance of homeostasis, orchestrating immune responses. With rapid exploitation development new technologies, there is a deeper understanding system. Here we review origin, important molecules, functions macrophages, mainly focusing on We also highlight some advances single-cell sequencing...
Abstract Spinal cord injury (SCI) is a devastating type of central nervous system (CNS) trauma with limited therapeutic treatments. The polarization microglia into the M1 or M2 state has been documented to play important roles in pathogenesis SCI, although complete repertoire underlying factors not identified. Interestingly, time point at which hematomyelia (intramedullary spinal hemorrhage) alleviated coincides decrease number microglia. Here function Hemopexin (Hpx), hematogenous...
LINGO-1 is a functional component of the Nogo receptor 1 · p75(NTR) and TAJ (TNFRSF19/TROY)·LINGO-1 signaling complexes. It has recently been shown that antagonists significantly improve neuronal survival after neural injury. However, mechanism by which influences susceptibility to apoptosis remains unknown. In an effort better understand how regulates these pathways, we used established model serum deprivation (SD) induce apoptosis. We demonstrate treatment either with construct containing...
The knowledge-based statistical potential has been widely used in protein structure modeling and model quality assessment. They are commonly evaluated based on their abilities of native recognition as well decoy discrimination. However, these two aspects found to be mutually exclusive many potentials. We developed an atomic ANgle- DIStance-dependent (ANDIS) for assessment with distance cutoff being a tunable parameter. When is ≤9.0 Å, "effective interaction" employed enhance the ability...