A5100620966- Radiomics and Machine Learning in Medical Imaging
- Immune Response and Inflammation
- Retinal Imaging and Analysis
- Esophageal and GI Pathology
- Photoacoustic and Ultrasonic Imaging
- Economic and Financial Impacts of Cancer
- Gut microbiota and health
- Corporate Finance and Governance
- Sepsis Diagnosis and Treatment
- Liver Diseases and Immunity
- Cancer Genomics and Diagnostics
- Radiation Therapy and Dosimetry
- Ophthalmology and Eye Disorders
- Cardiovascular Health and Disease Prevention
- Bladder and Urothelial Cancer Treatments
- Atherosclerosis and Cardiovascular Diseases
- Traditional Chinese Medicine Analysis
- Blood Pressure and Hypertension Studies
- Cancer Immunotherapy and Biomarkers
- Tea Polyphenols and Effects
- Liver Disease Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
University of Leeds
2023-2025
Nanjing University
2022-2024
State Key Laboratory of Kidney Diseases
2024
Community Health Center
2024
Chinese PLA General Hospital
2024
Chinese People's Liberation Army
2023-2024
Mindray (China)
2024
Jiangxi Agricultural University
2023
Nankai University
2023
Genistein, the major isoflavone in soybean, was recently reported to exert beneficial effects metabolic disorders and inflammatory diseases. In present study, we investigated mechanisms of a dietary concentration genistein on response lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Our results demonstrated that effectively inhibited LPS-induced overproduction tumor necrosis factor-alpha (TNF-α) interleukin 6 (IL-6), as well nuclear factor kappa B (NF-κB) activation. addition, data...
Immunotherapy has demonstrated a limited clinical efficacy in approximately 5% of cholangiocarcinoma. The main challenges for an effective immunotherapy response cholangiocarcinoma arise from the tumor microenvironment, which is poorly understood.
<title>Abstract</title> The full text of this preprint has been withdrawn by the authors since they no longer stand findings/conclusions work. Therefore, do not wish work to be cited as a reference. Questions should directed corresponding author.
Background Angiotensin II (AngII) participates in endothelial damage and inflammation, accelerates atherosclerosis. Endothelial lipase (EL) is involved the metabolism clearance of high density lipoproteins (HDL), serum levels which correlate negatively with onset cardiovascular diseases including However, relationship between AngII EL not yet fully understood. In this study, we investigated effects on expression signaling pathways that mediate its human umbilical vein cells (HUVECs). Methods...
Diabetic nephropathy (DN), as the one of most common complications diabetes, is generally diagnosed based on a longstanding duration, albuminuria, and decreased kidney function. Some patients with comorbidities diabetes other primary renal diseases have similar clinical features to DN, which defined non-diabetic disease (NDRD). It necessary distinguish between DN NDRD, considering they differ in their pathological characteristics, treatment regimes, prognosis. Renal biopsy provides gold...
Objective This study aimed to investigate the association between novel inflammatory markers (NIMs) and non-alcoholic fatty liver disease (NAFLD). Methods A total of 6306 subjects were enrolled in this cross-sectional study. NIMs, including neutrophil lymphocyte ratio (NLR), platelet (PLR), C-reactive protein albumin (CAR), monocyte (LMR), systemic immune-inflammation index (SII) prognostic nutritional (PNI), calculated. The prevalence NAFLD its with NIMs assessed by multivariable logistic...
ABSTRACT Objective To ascertain the impact of uterine leiomyomas on pregnancy outcome, and to determine effectiveness myomectomy at time caesarean delivery. Methods A retrospective study was conducted pregnant women with leiomyomas. Clinical information including course pregnancy, mode delivery, pathology findings, postpartum were extracted from medical records analysed for statistical significance. Results There 50 pregnancies associated During grew &gt;2 cm in 46% cases. Only 6%...
Objective To quantify the trends in systolic and diastolic blood pressure (BP) among adults Shenzhen from 1997 to 2018. Design Cross-sectional study. Settings The data were collected all districts Shenzhen, China years of 1997, 2009 2018 by multistage cluster sampling procedure. Participants residents aged 18–69 China. A total 26 621 people included: 8266 8599 9756 Primary secondary outcome measures All participants surveyed about their sociodemographic lifestyle information. BP was measured...
The potential risks arising from excessive supply chain concentration have received more and attention. In practice, high hinders firms’ sustainable development, especially for firms in emerging markets. However, how to reduce remains an underexplored problem. Outward foreign direct investment (OFDI) has been important strategy reallocate optimize their relationships. Thus, we tried explore whether OFDI can serve as effective method by analyzing relationship. Using the data of Chinese...
This paper takes A-share companies listed on the Shanghai and Shenzhen stock exchanges from 2011 to 2020 as research object empirically tests impact of fintech development corporate earnings management its mechanism. It is found that significantly reduces management. conclusion still holds after a series robustness tests. The mechanism test shows by alleviating information asymmetry easing financing constraints. A heterogeneity has greater effect reducing in non-state-owned enterprises,...
The impacts of interaction between proanthocyanidin (PC) and decolorized highland barley protein (DHBP) at pH 7 9 on the functional conformational changes in DHBP were investigated. It was shown that PC strongly quenched intrinsic fluorescence primarily through static quenching. mainly bound by hydrophobic interactions. Additionally, free sulfhydryl groups surface hydrophobicity obviously decreased after combining with PC. zeta potential DHBP–PC complexes increased significantly. A change...
This study aimed to investigate the effect of virtual reality (VR) technology in children after surgery for concomitant strabismus.A total 200 with exotropia or esotropia were randomly divided into a training group and control according single even number random method (100 cases each group). Patients received VR intervention within 1 week surgery. did not receive any training.Six months surgery, orthophoria (the far near strabismus degree was ≤8Δ) rate significantly higher than (P = 0.001),...
Summary Suppressor of cytokine signalling (SOCS) proteins are crucial negative regulators in many pathways and implicated the pathogenesis infectious diseases. The purpose this study was to uncover possible associations common polymorphisms within SOCS genes with outcomes after traumatic injury. A total 1087 trauma patients (Chongqing cohort 806 Yunnan 281) were recruited followed-up for development outcomes, such as sepsis multiple organ dysfunction syndrome (MODS). Twelve selected single...
The emergency rapid response system (RRS) can reduce the mortality of hospitalized patients, and its core is activation criteria team (RRT). This study adopted a bibliometric method to analyze research status RRSs for patients.The Science Citation Index Expanded (SCI-E) database was searched using keywords "emergency" "rapid system", search results were analyzed CiteSpace software. retrieved data included annual distribution studies literature citations; source country literature;...
Abstract Background The effects of oral contrast agents (OCAs) on dosimetry have not been studied in detail. Therefore, this study aimed to examine the influence OCAs dose calculation volumetric-modulated arc therapy plans for rectal cancer. Methods From 2008 2016, computed tomography (CT) images were obtained from 33 cancer patients administered OCA with or without intravenous agent (ICA) and 14 who received no agent. CT numbers organs at risk recorded converted electronic densities....
An amorphous 1.1 nm Ir/C catalyst exhibits ultralow overpotentials of 10 and 64 mV for the hydrogen evolution reaction at current densities 100 mA cm-2, together with 117 A mg-1 mass activity outstanding long-term durability, superior to those commercial Pt/C catalyst.
The objective was to explore the pharmacological mechanism of modified shengmaiyin (MSMY) in treatment acute lymphoblastic leukemia (ALL) by network pharmacology analysis. effective components and predicted targets MSMY were collected from TCMSP Swiss target prediction databases, related ALL screened GeneCards DisGeNET. core signaling pathways active ingredients for protein-protein interaction (PPI), gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) functional enrichment We...