A5022340430- Pesticide Exposure and Toxicity
- Retinoids in leukemia and cellular processes
- Heavy Metal Exposure and Toxicity
- Human Health and Disease
- Trace Elements in Health
- Water Quality Monitoring Technologies
- Vitamin C and Antioxidants Research
- Autism Spectrum Disorder Research
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Sulfur Compounds in Biology
- Child Nutrition and Feeding Issues
- Olfactory and Sensory Function Studies
- Genetics and Neurodevelopmental Disorders
University of Toledo
2022-2025
Pyrethroids are a class of commonly used synthetic insecticides, widely in agricultural and residential settings due to their efficacy relatively low environmental impact. Nonetheless, epidemiological studies have found that exposure pyrethroids during developmental stages is linked risk for neurodevelopmental disorders. However, the molecular mechanisms behind these neurotoxic effects remain unclear. Our study investigates impact oral deltamethrin, Type II pyrethroid pesticide, on gene...
Neurodevelopmental disorders (NDDs) are a category of pervasive the developing nervous system with few or no recognized biomarkers. A significant portion risk for NDDs, including attention deficit hyperactivity disorder (ADHD), is contributed by environment, and exposure to pyrethroid pesticides during pregnancy has been identified as potential factor NDD in unborn child. We recently showed that low-dose developmental pesticide deltamethrin mice causes male-biased changes ADHD- NDD-relevant...
Human-generated negative impacts on aquatic environments are rising. Despite wild fish playing a key role in ecologies and comprising major global food source, physiological consequences of these them poorly understood. Here we address the issue through lens interrelationship between their gut microbiota, hypothesizing that microbiota reporters environs. Two geographically separate teleost wild-fish species were studied (Lake Erie, Ohio, Caribbean Sea, US Virgin Islands). At each...
Neurodevelopmental disorders (NDDs) are a category of pervasive the developing nervous system with few or no recognized biomarkers. A significant portion risk for NDDs, including attention deficit hyperactivity disorder (ADHD), is contributed by environment, and exposure to pyrethroid pesticides during pregnancy has been identified as potential factor NDD in unborn child. We recently showed that low-dose developmental pesticide deltamethrin mice causes male-biased changes ADHD- NDD-relevant...
Environmental and genetic risk factors, their interactions, contribute significantly to the etiology of neurodevelopmental disorders (NDDs). Recent epidemiology studies have implicated pyrethroid pesticides as an environmental factor for autism developmental delay. Our previous research showed that low-dose exposure pesticide deltamethrin in mice caused male-biased changes brain NDD-relevant behaviors adulthood. Here, we used a metabolomics approach determine broadest possible set metabolic...
Abstract Environmental and genetic risk factors, their interactions, contribute significantly to the etiology of neurodevelopmental disorders (NDDs). Recent epidemiology studies have implicated pyrethroid pesticides as an environmental factor for autism developmental delay. Our previous research showed that low-dose exposure pesticide deltamethrin in mice caused male-biased changes brain NDD-relevant behaviors adulthood. Here, we used a metabolomics approach determine broadest possible set...
Translation: The University of Toledo Journal Medical Sciences is the online journal launched by Toledo. Manuscripts will be considered on understanding that they report original work and are not under consideration for publication any other journal. publishes articles reporting experimental results basic or clinical research, case reports, reviews. uses a single blind peer review system each manuscript, based presented in its submission, evaluated two student reviewers one faculty reviewer....
Translation: The University of Toledo Journal Medical Sciences is the online journal launched by Toledo. Manuscripts will be considered on understanding that they report original work and are not under consideration for publication any other journal. publishes articles reporting experimental results basic or clinical research, case reports, reviews. uses a single blind peer review system each manuscript, based presented in its submission, evaluated two student reviewers one faculty reviewer....
Translation: The University of Toledo Journal Medical Sciences is the online journal launched by Toledo. Manuscripts will be considered on understanding that they report original work and are not under consideration for publication any other journal. publishes articles reporting experimental results basic or clinical research, case reports, reviews. uses a single blind peer review system each manuscript, based presented in its submission, evaluated two student reviewers one faculty reviewer....
Neurodevelopmental disorders (NDDs) have dramatically increased in prevalence to an alarming one six children, and yet both causes preventions remain elusive. Recent human epidemiology animal studies implicated developmental exposure pyrethroid pesticides, of the most common classes pesticides US, as environmental risk factor for autism neurodevelopmental disorders. Our previous research has shown that low-dose chronic (DPE) changes folate metabolites adult mouse brain. We hypothesize DPE...