A5050461905- Neuroendocrine regulation and behavior
- Pesticide Exposure and Toxicity
- Neuroscience and Neuropharmacology Research
- Evolutionary Psychology and Human Behavior
- Retinoids in leukemia and cellular processes
- Cellular transport and secretion
- Memory and Neural Mechanisms
- Olfactory and Sensory Function Studies
- Attachment and Relationship Dynamics
- Genetic and Kidney Cyst Diseases
- Human Health and Disease
- Neurobiology and Insect Physiology Research
- Microtubule and mitosis dynamics
- Lipid Membrane Structure and Behavior
- Trace Elements in Health
- Neuroscience of respiration and sleep
- Advanced Chemical Sensor Technologies
- Child and Adolescent Psychosocial and Emotional Development
- Heavy Metal Exposure and Toxicity
- Circadian rhythm and melatonin
- Genetic Neurodegenerative Diseases
- Tryptophan and brain disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Primate Behavior and Ecology
- Sulfur Compounds in Biology
University of Toledo
2020-2025
Marymount University
2024
Emory University
2009-2024
Emory National Primate Research Center
2011-2012
Center for Neurosciences
2011
Consolation behavior toward distressed others is common in humans and great apes, yet our ability to explore the biological mechanisms underlying this limited by its apparent absence laboratory animals. Here, we provide empirical evidence that a rodent species, highly social monogamous prairie vole (Microtus ochrogaster), greatly increases partner-directed grooming familiar conspecifics (but not strangers) have experienced an unobserved stressor, providing buffering. Prairie voles also match...
Abstract Centrioles are subcellular organelles found at the cilia base with an evolutionarily conserved structure and a shock absorber-like function. In sperm, centrioles flagellum essential for embryo development in basal animals. Yet, sperm have evolved diverse forms, sometimes acting like transmission system, as cattle, becoming dispensable, house mice. How centriole to become dispensable some organisms is unclear. Here, we test hypothesis that this transition occurred through cascade of...
Abstract Dopaminergic neurons of the substantia nigra exist in a persistent state vulnerability resulting from high baseline oxidative stress, high‐energy demand, and broad unmyelinated axonal arborisations. Impairments storage dopamine compound this stress because cytosolic reactions that transform vital neurotransmitter into an endogenous neurotoxicant, toxicity is thought to contribute neuron degeneration occurs Parkinson's disease. We have previously identified synaptic vesicle...
Pyrethroids are a class of commonly used synthetic insecticides, widely in agricultural and residential settings due to their efficacy relatively low environmental impact. Nonetheless, epidemiological studies have found that exposure pyrethroids during developmental stages is linked risk for neurodevelopmental disorders. However, the molecular mechanisms behind these neurotoxic effects remain unclear. Our study investigates impact oral deltamethrin, Type II pyrethroid pesticide, on gene...
Neurodevelopmental disorders (NDDs) are a category of pervasive the developing nervous system with few or no recognized biomarkers. A significant portion risk for NDDs, including attention deficit hyperactivity disorder (ADHD), is contributed by environment, and exposure to pyrethroid pesticides during pregnancy has been identified as potential factor NDD in unborn child. We recently showed that low-dose developmental pesticide deltamethrin mice causes male-biased changes ADHD- NDD-relevant...
Neurodevelopmental disorders (NDDs) are a widespread and growing public health challenge, affecting as many 17% of children in the United States. Recent epidemiological studies have implicated ambient exposure to pyrethroid pesticides during pregnancy risk for NDDs unborn child. Using litter-based, independent discovery-replication cohort design, we exposed mouse dams orally lactation Environmental Protection Agency's reference pyrethroid, deltamethrin, at 3 mg/kg, concentration well below...
Environmental and genetic risk factors, their interactions, contribute significantly to the etiology of neurodevelopmental disorders (NDDs). Recent epidemiology studies have implicated pyrethroid pesticides as an environmental factor for autism developmental delay. Our previous research showed that low-dose exposure pesticide deltamethrin in mice caused male-biased changes brain NDD-relevant behaviors adulthood. Here, we used a metabolomics approach determine broadest possible set metabolic...
Abstract A subset of people exposed to a traumatic event develops post‐traumatic stress disorder (PTSD), which is associated with dysregulated fear behavior. Genetic variation in SLC18A2 , the gene that encodes vesicular monoamine transporter 2 (VMAT2), has been reported affect risk for development PTSD humans. Here, we use transgenic mice express either 5% (VMAT2‐LO mice) or 200% (VMAT2‐HI wild‐type levels VMAT2 protein. We report VMAT2‐LO have reduced protein hippocampus and amygdala,...
Neurodevelopmental disorders (NDDs) are a category of pervasive the developing nervous system with few or no recognized biomarkers. A significant portion risk for NDDs, including attention deficit hyperactivity disorder (ADHD), is contributed by environment, and exposure to pyrethroid pesticides during pregnancy has been identified as potential factor NDD in unborn child. We recently showed that low-dose developmental pesticide deltamethrin mice causes male-biased changes ADHD- NDD-relevant...
Dopaminergic neurons of the substantia nigra exist in a persistent state vulnerability resulting from high baseline oxidative stress, energy demand, and broad unmyelinated axonal arborizations. Impairments storage dopamine compound this stress due to cytosolic reactions that transform vital neurotransmitter into an endogenous neurotoxicant, toxicity is thought contribute neuron degeneration occurs Parkinson's disease. We have previously identified synaptic vesicle glycoprotein 2C (SV2C) as...
Abstract Environmental and genetic risk factors, their interactions, contribute significantly to the etiology of neurodevelopmental disorders (NDDs). Recent epidemiology studies have implicated pyrethroid pesticides as an environmental factor for autism developmental delay. Our previous research showed that low-dose exposure pesticide deltamethrin in mice caused male-biased changes brain NDD-relevant behaviors adulthood. Here, we used a metabolomics approach determine broadest possible set...
Translation: The University of Toledo Journal Medical Sciences is the online journal launched by Toledo. Manuscripts will be considered on understanding that they report original work and are not under consideration for publication any other journal. publishes articles reporting experimental results basic or clinical research, case reports, reviews. uses a single blind peer review system each manuscript, based presented in its submission, evaluated two student reviewers one faculty reviewer....
Translation: The University of Toledo Journal Medical Sciences is the online journal launched by Toledo. Manuscripts will be considered on understanding that they report original work and are not under consideration for publication any other journal. publishes articles reporting experimental results basic or clinical research, case reports, reviews. uses a single blind peer review system each manuscript, based presented in its submission, evaluated two student reviewers one faculty reviewer....
Neurodevelopmental disorders (NDDs) have dramatically increased in prevalence to an alarming one six children, and yet both causes preventions remain elusive. Recent human epidemiology animal studies implicated developmental exposure pyrethroid pesticides, of the most common classes pesticides US, as environmental risk factor for autism neurodevelopmental disorders. Our previous research has shown that low-dose chronic (DPE) changes folate metabolites adult mouse brain. We hypothesize DPE...