A5101848986- Tryptophan and brain disorders
- Bioinformatics and Genomic Networks
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Plant Pathogens and Fungal Diseases
- Single-cell and spatial transcriptomics
- Traditional Chinese Medicine Analysis
- Neuroscience and Neuropharmacology Research
- Genetic Associations and Epidemiology
- Gene Regulatory Network Analysis
- Computational Drug Discovery Methods
- Cell Image Analysis Techniques
- Epilepsy research and treatment
- HIV Research and Treatment
- Spine and Intervertebral Disc Pathology
- Alzheimer's disease research and treatments
- SARS-CoV-2 and COVID-19 Research
- Medicinal Plant Pharmacodynamics Research
- Adipose Tissue and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Genetics and Neurodevelopmental Disorders
- Ginseng Biological Effects and Applications
- Lipid metabolism and disorders
- Plant nutrient uptake and metabolism
- Cutaneous lymphoproliferative disorders research
University of Southern California
2021-2025
University of Toledo
2020-2024
Sibley Memorial Hospital
2022
Kunming University
2012-2020
Johns Hopkins Hospital
2020
Jiaxing University
2020
Carnegie Mellon University
2018
Henry Ford Health System
2018
Wuxi Taihu Hospital
2017
Air Force Medical University
2017
Biological systems exhibit complex dynamics that differential equations can often adeptly represent. Ordinary equation models are widespread; until recently their construction has required extensive prior knowledge of the system. Machine learning methods offer alternative means model construction: be learnt from data via discovery using sparse identification nonlinear (SINDy). However, SINDy struggles with realistic levels biological noise and is limited in its ability to incorporate We...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic, infecting over 16 million people with significant mortality rate. However, there is no current Food and Drug Administration-approved drug that treats disease 2019 (COVID-19). Damage to T lymphocytes along the cytokine storm are important factors lead exacerbation of clinical cases. Here, we proposing intravenous oxytocin (OXT) as candidate for adjunctive therapy COVID-19. OXT anti-inflammatory...
Neural crest (NC) cells migrate throughout vertebrate embryos to give rise a huge variety of cell types, but when and where lineages emerge their regulation remain unclear. We have performed single-cell RNA sequencing (RNA-seq) cranial NC from the first pharyngeal arch in zebrafish over several stages during migration. Computational analysis combining pseudotime real-time data reveals that these adopt transitional state, becoming specified mid-migration, with lineage decisions being skeletal...
Abstract The COVID-19 pandemic caused by the novel SARS-CoV-2 is more contagious than other coronaviruses and has higher rates of mortality influenza. Identification effective therapeutics a crucial tool to treat those infected with limit spread this disease globally. We deployed bioinformatics workflow identify candidate drugs for treatment COVID-19. Using an “omics” repository, Library Integrated Network-Based Cellular Signatures (LINCS), we simultaneously probed transcriptomic signatures...
Abstract The common molecular mechanisms underlying psychiatric disorders are not well understood. Prior attempts to assess the pathological responsible for have been limited by biased selection of comparable disorders, datasets/cohort availability, and challenges with data normalization. Here, using DisGeNET, a gene-disease associations database, we sought expand such investigations in terms number types diseases. In top-down manner, analyzed an unbiased cluster 36 comorbid conditions at...
The tuberous root of Tetrastigma hemsleyanum Diels et Gilg (T. hemsleyanum) is a traditional Chinese medicine with wide range clinical applications. However, the scarcity its wild resources, low yield, and variable quality that results from artificial cultivation leads to expensive market prices are not conducive further industrial development T. hemsleyanum. In this study, transcriptomic non-targeted metabolomic analyses were integrated explore underlying molecular mechanisms metabolite...
Abstract Background Poor physical function is strongly associated with mortality and poor clinical outcomes in adults chronic kidney disease (CKD). Handgrip strength (HGS) an important index for the general population, association between HGS CKD worth investigating. Methods From September to November 2015, we conducted a cross-sectional study consisting of 10,407 participants Jurong City, China. Age-related sex-specific percentile curves were constructed using GAMLSS method. In addition,...
In September 2010, symptoms of blueberry stem blight were observed on highbush blueberries (Vaccinium corymbosum) in Lijiang and Qujing, Yunnan province (southwestern China). Symptoms included dieback, twig (Fig. 1) extensive dull brown vascular discolouration 2A), with crop damage ranging from 10 to 17%. These similar but distinctive those caused by N. vitifusiforme, confirmed 2008 as a pathogen China (Kong et al., 2). vitifusiforme causes characteristic reddish-brown the system well...
Blueberry (Vaccinium spp.) production in southwest and northeast China has grown to over 100,000 ha the last 20 years thanks fruit's high nutritional economic value. As blueberry acreage increases, diversity of diseases challenges for control are gaining more attention. In August 2010, stem branch blight occurred on Highbush Blueberries corymbosum L.) at commercial farms Lijiang Zongdian, Yunnan Province (southwestern China), with crop damage ranging from 10 15%. Typical symptoms disease...
Opioids are widely used for treating different types of pains, but overuse and abuse prescription opioids have led to opioid epidemic in the United States. Besides analgesic effects, chronic use can also cause tolerance, dependence, even addiction. Effective treatment addiction remains a big challenge today. Studies on addictive effects focus striatum, main component brain responsible drug dependence Some transcription regulators been associated with addiction, relationship between behaviors...
Abstract Animal models have expanded our understanding of temporal lobe epilepsy (TLE). However, translating these to cell-specific druggable hypotheses is not explored. Herein, we conducted an integrative insilico-analysis available transcriptomics dataset obtained from animals with pilocarpine-induced-TLE. A set 119 genes subtle-to-moderate impact predicted most forms ~ 97% accuracy and characteristically mapped upregulated homeostatic downregulated synaptic pathways. The deconvolution...
Astrocytes have many important functions in the brain, but their roles psychiatric disorders and responses to psychotropic medications are still being elucidated. Here, we used gene enrichment analysis assess relationships between different astrocyte subtypes, diseases, (antipsychotics, antidepressants mood stabilizers). We also carried out qPCR analyses "look-up" studies chronic effects of these drugs on marker expression. Our bioinformatic identified subtypes disorders. The highest level...
Abstract The COVID-19 pandemic caused by the novel SARS-CoV-2 is more contagious than other coronaviruses and has higher rates of mortality influenza. As no vaccine or drugs are currently approved to specifically treat COVID-19, identification effective therapeutics crucial afflicted limit disease spread. We deployed a bioinformatics workflow identify candidate for treatment COVID-19. Using an “omics” repository, Library Integrated Network-Based Cellular Signatures (LINCS), we simultaneously...
Single-cell genomic technologies offer vast new resources with which to study cells, but their potential inform parameter inference of cell dynamics has yet be fully realized. Here we develop methods for Bayesian data that jointly measure gene expression and Ca2+ in single cells. We propose share information between cells via transfer learning: a sequence the posterior distribution one is used prior next. In application intracellular signalling dynamics, fit parameters dynamical model...
Abstract Background Schizophrenia (SCZ) is a serious mental illness with complex pathology, including abnormalities in the glutamate system. Glutamate rapidly removed from synapse by excitatory amino acid transporters (EAATs). Changes expression and localization of primary transporter EAAT2 are found brain central nervous system (CNS) disorders SCZ. We hypothesize that neuronal function increased frontal cortex subjects diagnosed Study Design protein were assayed synaptosome preparations...
Abstract While the pathophysiology of schizophrenia has been extensively investigated using homogenized postmortem brain samples, few studies have examined changes in samples with techniques that may attribute perturbations to specific cell types. To fill this gap, we performed microarray assays on mRNA isolated from anterior cingulate cortex (ACC) superficial and deep pyramidal neurons 12 control subjects laser capture microdissection. Among all annotated genes, identified 134 significantly...
Objective The safety profile of traditional Chinese medicine injections has emerged as the greatest challenge to their clinical application. authors aimed perform a post-marketing surveillance study in real-world setting evaluate Xuesaitong (XST) injection China.Methods This multi-centre, post-marketing, observational enrolled patients who received XST 42 centres China between March 2015 and November 2017. Adverse drug reactions (ADRs) adverse events (ADEs) were collected evaluated database....