A5014542203- Ovarian cancer diagnosis and treatment
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Cancer Mechanisms and Therapy
- Reproductive Biology and Fertility
- Cancer Genomics and Diagnostics
- Animal Virus Infections Studies
- Immune Cell Function and Interaction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immune cells in cancer
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Bone Tumor Diagnosis and Treatments
- Cancer, Hypoxia, and Metabolism
- Congenital heart defects research
- TGF-β signaling in diseases
- Lung Cancer Research Studies
- Receptor Mechanisms and Signaling
- Plant responses to water stress
- Maternal and Perinatal Health Interventions
- Neuropeptides and Animal Physiology
- Parasitic infections in humans and animals
- bioluminescence and chemiluminescence research
Chengdu University of Traditional Chinese Medicine
2025
Imperial College London
2021-2024
Nanjing Drum Tower Hospital
2024
Ovarian Cancer Action
2021-2024
Cancer Research UK Cambridge Center
2024
University of Cambridge
2024
Peking University Third Hospital
2024
Peking University
2024
University of Macau
2020-2023
Hebei Medical University
2023
Abstract Purpose: Ovarian high-grade serous carcinoma (HGSC) is usually diagnosed at late stage. We investigated whether late-stage HGSC has unique genomic characteristics consistent with acquisition of evolutionary advantage compared early-stage tumors. Experimental Design: performed targeted next-generation sequencing and shallow whole-genome (sWGS) on pretreatment samples from 43 patients FIGO stage I–IIA to investigate somatic mutations copy-number (CN) alterations (SCNA). results 52...
Ovarian high-grade serous carcinoma (HGSC) prognosis correlates directly with presence of intratumoral lymphocytes. However, cancer immunotherapy has yet to achieve meaningful survival benefit in patients HGSC. Epigenetic silencing immunostimulatory genes is implicated immune evasion HGSC and re-expression these could promote tumor clearance. We discovered that simultaneous inhibition the histone methyltransferases G9A EZH2 activates CXCL10-CXCR3 axis increases homing effector lymphocytes...
Importance Patients with platinum-resistant or refractory ovarian high-grade serous carcinoma (PR-HGSC) have a poor prognosis and few therapeutic options. Preclinical studies support targeting PI3K/AKT/mTOR signaling in this setting, phase 1 study of the dual mTORC1/mTORC2 inhibitor vistusertib weekly paclitaxel showed activity. Objective To evaluate whether addition to improves clinical outcomes patients PR-HGSC. Design, Setting, Participants This 2, double-blind, placebo-controlled...
Activin and inhibin are both dimeric proteins sharing the same β subunits that belong to TGF-β superfamily. They well known for stimulating inhibiting pituitary FSH secretion, respectively, in mammals. In addition, activin also acts as a mesoderm-inducing factor frogs. However, their functions development reproduction of other species poorly defined. this study, we disrupted all three activin/inhibin (βAa, inhbaa ; βAb, inhbab βB, inhbb ) zebrafish using CRISPR/Cas9. The loss βAa/b but not...
As an oocyte-specific growth factor, bone morphogenetic protein 15 (BMP15) plays a critical role in controlling folliculogenesis. However, the mechanism of BMP15 action remains elusive. Using zebrafish as model, we created bmp15 mutant using CRISPR/Cas9 and demonstrated that deficiency caused significant delay follicle activation puberty onset followed by complete arrest development at previtellogenic (PV) stage without yolk accumulation. The females eventually underwent female-to-male sex...
Abstract Ovarian high‐grade serous carcinoma (HGSC) originates in the fallopian tube, with secretory cells carrying a TP53 mutation, known as p53 signatures, identified potential precursors. signatures evolve into tubal intraepithelial (STIC) lesions, which turn progress invasive HGSC, readily spreads to ovary and disseminates around peritoneal cavity. We recently investigated genomic landscape of early‐ late‐stage HGSC found higher ploidy (median 3.1) than early‐stage 2.0) samples. Here,...
Dextran sulfate sodium (DSS) is commonly used in rodent IBD models to chemically induce acute intestinal inflammation. The course of colitis includes colon tissue damages and recovery from wounded tissues. As skin wound repair was delayed by splenectomy, we asked whether splenectomy would the delay colonic healing. In splenectomized mice, body weight recovery, disease score length were delayed. Surprisingly found a great increase Gr1+CD11b+ cells spleen bone marrow DSS-administered mice....
Controlling translation initiation is an efficient way to regulate gene expression at the post-transcriptional level. However, current knowledge regarding regulatory proteins and their modes of controlling still limited. In this study, we employed tandem affinity purification mass spectrometry screen for unknown associated with machinery. Ubiquitin specific peptidase 9, X-linked (USP9X), was identified as a novel binding partner, that interacts eukaryotic factor 4B (eIF4B) in...
Abstract Inhibin was first characterized in mammals as a gonadal dimeric protein that inhibited pituitary follicle-stimulating hormone (FSH) secretion. As mammals, the inhibin-specific α subunit (INHA/Inha/inha) has also been teleosts; however, its functions and physiological importance fish reproduction remain unknown. Using CRISPR/Cas9 method, we generated an inha-deficient zebrafish line analyzed reproductive performance. expected, expression of fshb increased significantly both young...
Abstract FIGLA and NOBOX are important oocyte-specific transcription factors. Both figla-/- nobox-/- mutants showed all-male phenotype in zebrafish due to increased dominance of the male-promoting pathway. The early diversion towards males these has precluded analysis their roles folliculogenesis. In this study, we attenuated pathway by deleting dmrt1 , a key gene, fish, which allows sufficient display defects Germ cells figla-/-;dmrt1 -/- double mutant remained cysts without forming...
Abstract We aimed to comprehensively investigate the proteomic profile and underlying biological function of exosomal proteins associated with B-cell acute lymphoblastic leukemia. Exosomes were isolated from plasma samples collected five patients B-ALL healthy individuals, their protein content was quantitatively analyzed by liquid chromatography tandem mass spectrometry. A total 342 differentially expressed identified in B-ALL. The DEPs mainly metabolic processes activity regulation...
Abstract Ovarian high-grade serous carcinoma (HGSC) originates in the fallopian tube, with secretory cells carrying a TP53 mutation, known as ‘p53 signatures’, identified potential precursors. p53 signatures evolve into tubal intraepithelial carcinomas (STIC) lesions, which, turn, progress invasive HGSC that readily spread to ovary and disseminate around peritoneal cavity. We recently investigated genomic landscape of early- late-stage found higher ploidy (median 3.1) than early-stage 2.0)...
Immune checkpoint inhibitors (ICIs) are currently the first line of tumor immunotherapy for treatment a wide range tumors. However, main side effect immune is that they cause immune-related adverse events (irAEs) in patients. The relationship between occurrence effects patients and efficacy controversial. objective this study was to confirm who develop thyroid dysfunction after efficacy. This retrospective real-world clinical study, total 50 with advanced tumors treated at Anqing People's...
The potent carcinogenicity of dibenzo[a,l]pyrene (DB[a,l]P) in mouse skin is associated with an inflammatory response and a striking epidermal hyperplasia. mechanism these tissue responses not known. However, recent study has shown DB[a,l]P to be contact sensitizer. In view the programmed expression cytokines during induction hypersensitivity (CHS) elicitation CHS reactions, we analyzed cytokine mRNAs treated draining lymph nodes SENCAR mice, at selected times after single, epicutaneous...
Abstract Background Intravenous oxytocin is commonly used for labor induction. However, a consensus on the initial dosing regimen lac with conflicting research findings and varying guidelines. This study aimed to develop population kinetic‐pharmacodynamic (K‐PD) model oxytocin‐induced uterine contractions considering real‐world data relevant influencing factors establish an optimal starting intravenous oxytocin. Methods retrospective included pregnant women who underwent induction at Peking...
Abstract Purpose High grade serous carcinoma (HGSC) is the commonest type of ovarian cancer. Nearly all HGSC cases are diagnosed at late stage and it not clear whether early has unique characteristics compared to tumours. Experimental Design We analysed samples from 45 patients with FIGO I - IIA 40 pathology archives three large UK cancer centres 5 BriTROC-1 study. performed shallow whole genome sequencing (sWGS) targeted next generation investigate somatic mutations copy number alterations....
Abstract The majority of high-grade serous carcinomas (HGSC) originate in the fallopian tube. Secretory epithelial cells carrying a TP53 mutation, known as "p53 signatures", are earliest precursor lesions HGSC. According to current theories, p53 signatures then evolve into tubal intraepithelial (STIC) lesions, which, turn, progress invasive HGSC that spreads ovary and other metastatic sites. We recently investigated genomic landscape early late-stage demonstrated presence whole-genome...
Abstract As an oocyte-specific growth factor, bone morphogenetic protein 15 (BMP15) plays a critical role in controlling folliculogenesis. However, the mechanism of BMP15 action remains elusive. Using zebrafish as model, we created bmp15 mutant using CRISPR/Cas9 and demonstrated that deficiency caused significant delay follicle activation puberty onset followed by complete arrest development at previtellogenic stage without yolk accumulation. The females eventually underwent female-to-male...
Abstract Activin and inhibin are both dimeric proteins sharing the same β subunits that belong to TGF-β superfamily. They well known for stimulating inhibiting pituitary FSH secretion, respectively, in mammals. In addition, activin also acts as a mesoderm-inducing factor frogs. However, their functions development reproduction of other species poorly defined. this study, we disrupted all three activin/inhibin (βAa, inhbaa ; βAb, inhbab βB, inhbb ) zebrafish using CRISPR/Cas9. The loss βAa/b...
Abstract Ovarian high-grade serous carcinoma (HGSC) prognosis correlates directly with presence of intratumoral lymphocytes. However, cancer immunotherapy has yet to achieve meaningful survival benefit in patients HGSC. Epigenetic silencing immunostimulatory genes is implicated immune evasion HGSC and re-expression these could promote tumour clearance. We discovered that simultaneous inhibition the histone methyltransferases G9A EZH2 activates CXCL10-CXCR3 axis increases homing effector...
Supplementary Figure from The Genomic Landscape of Early-Stage Ovarian High-Grade Serous Carcinoma