A5063726930- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- PARP inhibition in cancer therapy
- Renal cell carcinoma treatment
Imperial College London
2020-2024
Ovarian Cancer Action
2020-2024
Hammersmith Hospital
2022
University of Glasgow
2020
Abstract Ovarian high-grade serous carcinoma (HGSC) originates in the fallopian tube, with secretory cells carrying a TP53 mutation, known as ‘p53 signatures’, identified potential precursors. p53 signatures evolve into tubal intraepithelial carcinomas (STIC) lesions, which, turn, progress invasive HGSC that readily spread to ovary and disseminate around peritoneal cavity. We recently investigated genomic landscape of early- late-stage found higher ploidy (median 3.1) than early-stage 2.0)...
Abstract Purpose High grade serous carcinoma (HGSC) is the commonest type of ovarian cancer. Nearly all HGSC cases are diagnosed at late stage and it not clear whether early has unique characteristics compared to tumours. Experimental Design We analysed samples from 45 patients with FIGO I - IIA 40 pathology archives three large UK cancer centres 5 BriTROC-1 study. performed shallow whole genome sequencing (sWGS) targeted next generation investigate somatic mutations copy number alterations....