A5040316427- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Mast cells and histamine
- Kruppel-like factors research
- Immune cells in cancer
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Eosinophilic Disorders and Syndromes
- PI3K/AKT/mTOR signaling in cancer
- Eosinophilic Esophagitis
- Systemic Sclerosis and Related Diseases
- IL-33, ST2, and ILC Pathways
- Pulmonary Hypertension Research and Treatments
- Ion Transport and Channel Regulation
- Genomics, phytochemicals, and oxidative stress
- ATP Synthase and ATPases Research
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
Imperial College London
2022-2024
Ovarian Cancer Action
2022-2023
Ovarian high-grade serous carcinoma (HGSC) prognosis correlates directly with presence of intratumoral lymphocytes. However, cancer immunotherapy has yet to achieve meaningful survival benefit in patients HGSC. Epigenetic silencing immunostimulatory genes is implicated immune evasion HGSC and re-expression these could promote tumor clearance. We discovered that simultaneous inhibition the histone methyltransferases G9A EZH2 activates CXCL10-CXCR3 axis increases homing effector lymphocytes...
ADP-ribosylation factor 6 (ARF6), a GTPase associated with cancer metastasis, is activated in the lung endothelium pulmonary arterial hypertension (PAH). To identify ARF6-regulated pathways relevant to PAH, we performed state-of-the-art proteomic analysis of human artery endothelial cells (HPAECs) overexpressing wildtype, constitutively active, fast-cycling and dominant negative mutants ARF6. The revealed novel link ARF6 hypoxia-inducible (HIF), addition endocytotic vesicle trafficking, cell...
High-grade serous ovarian carcinoma (HGSC) remains a disease with poor prognosis that is unresponsive to current immune checkpoint inhibitors. Although PI3K pathway alterations, such as PTEN loss, are common in HGSC, attempts target this have been unsuccessful. We hypothesized aberrant activation may alter the HGSC microenvironment and present targeting opportunity. Single-cell RNA sequencing identified populations of resident macrophages specific Pten-null omental tumors murine models,...
<p>Legends to supplementary figures</p>
<div>Abstract<p>High-grade serous ovarian carcinoma (HGSC) remains a disease with poor prognosis that is unresponsive to current immune checkpoint inhibitors. Although PI3K pathway alterations, such as <i>PTEN</i> loss, are common in HGSC, attempts target this have been unsuccessful. We hypothesized aberrant activation may alter the HGSC microenvironment and present targeting opportunity. Single-cell RNA sequencing identified populations of resident macrophages...
<p>Table of antibodies used in flow cytometry and immunohistochemistry.</p>
<p>Genes upregulated in each mouse macrophage cluster</p>
<p>8 supplementary figures</p>
<p>Up- and down-regulated differentially expressed genes in HMOX1-hi human macrophages</p>
<p>Description of supplementary methods</p>
<p>Description of supplementary methods</p>
<p>Genes upregulated in each mouse macrophage cluster</p>
<p>Up- and down-regulated differentially expressed genes in HMOX1-hi human macrophages</p>
<p>Legends to supplementary figures</p>
<p>8 supplementary figures</p>
<p>Table of antibodies used in flow cytometry and immunohistochemistry.</p>
Abstract Ovarian high grade serous carcinoma (HGSC) remains a disease of poor prognosis that is unresponsive to current immune checkpoint inhibitors. Although PI3K pathway alterations are common in HGSC, attempts target this have been unsuccessful. We hypothesised aberrant activation may alter the HGSC microenvironment and present novel targeting strategy. used both murine models patient samples study impact loss Pten , negative regulator signalling. identified populations resident...
ABSTRACT ADP-ribosylation factor 6 (ARF6), a GTPase associated with cancer metastasis, is activated in the lung endothelium pulmonary arterial hypertension (PAH). To identify ARF6-regulated pathways relevant to PAH, we performed state-of-the-art proteomic analysis of human artery endothelial cells (HPAECs) overexpressing wildtype, constitutively active, fast-cycling and dominant negative mutants ARF6. The revealed novel link ARF6 hypoxia-inducible (HIF), addition endocytotic vesicle...
Abstract Aberrant cMYC activity is a key driver of cancer, involved in several hallmark processes. Alongside the canonical proliferation, represses immune signalling cell-intrinsic manner. The histone methyltransferases EZH2 and G9a interact with to modulate gene expression, including repression genes via H3K27 H3K9 methylation. Analyses 565 cell lines derived from solid cancers demonstrated that greater cMYC-G9a/EZH2-mediated correlates lower scores manner (innate, Type I II IFN response),...
<div>Abstract<p>Ovarian high-grade serous carcinoma (HGSC) prognosis correlates directly with presence of intratumoral lymphocytes. However, cancer immunotherapy has yet to achieve meaningful survival benefit in patients HGSC. Epigenetic silencing immunostimulatory genes is implicated immune evasion HGSC and re-expression these could promote tumor clearance. We discovered that simultaneous inhibition the histone methyltransferases G9A EZH2 activates CXCL10–CXCR3 axis increases...
Supplementary Figure from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma
Supplementary Data from Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma