A5054095477- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Distributed systems and fault tolerance
- Reproductive Biology and Fertility
- Advanced Data Storage Technologies
- Parallel Computing and Optimization Techniques
- Animal Genetics and Reproduction
- Asymmetric Synthesis and Catalysis
- Genomics, phytochemicals, and oxidative stress
- Optimization and Search Problems
- Glutathione Transferases and Polymorphisms
- Axial and Atropisomeric Chirality Synthesis
- Advanced Database Systems and Queries
- Software System Performance and Reliability
- Reproductive biology and impacts on aquatic species
- Bone Tumor Diagnosis and Treatments
- Ideological and Political Education
- Invertebrate Immune Response Mechanisms
- Data Management and Algorithms
- Synthesis and Catalytic Reactions
- Epigenetics and DNA Methylation
- Synthesis and Characterization of Pyrroles
- Transplantation: Methods and Outcomes
- Congenital heart defects research
- Sexual Differentiation and Disorders
- Cancer, Hypoxia, and Metabolism
University of Macau
2019-2025
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2022-2025
Sun Yat-sen University
2021-2025
North China Electric Power University
2023-2024
Hainan University
2024
Jilin University
2011-2023
Cornell University
2023
Union Hospital
2023
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2022
Ocean University of China
2022
The IBM Streams Processing Language (SPL) is the programming language for InfoSphere® Streams, a platform analyzing Big Data in motion. By "Big motion," we mean continuous data streams at high data-transfer rates. InfoSphere processes such with both throughput and short response times. To meet these performance demands, it deploys each application on cluster of commodity servers. SPL abstracts away complexity distributed system, instead exposing simple graph-of-operators view to user. has...
Change management is a process by which IT systems are modified to accommodate considerations such as software fixes, hardware upgrades and performance enhancements. This paper discusses the CHAMPS system, prototype under development at IBM Research for Management with Planning Scheduling. The system able achieve very high degree of parallelism set tasks exploiting detailed factual knowledge about structure distributed from dependency information runtime. In contrast, today's expect an...
BINOL and VAPOL-derived double axially chiral bisphosphorylimide catalysts enable the atom-economical highly enantioselective Friedel—Crafts reaction between indoles N-tosylimines with a low catalyst loading.
Sex determination and differentiation are complex processes controlled by many different factors; however, the relationships among these factors poorly understood. Zebrafish gonadal exhibits high plasticity involving multiple pathways, which provides an excellent model for investigating interactions them. Ovarian aromatase (cyp19a1a) dmrt1 key in directing vertebrate ovary testis differentiation, respectively. Knockout of zebrafish cyp19a1a led to all-male offspring, whereas loss resulted a...
SpeedTracer, a World Wide Web usage mining and analysis tool, was developed to understand user surfing behavior by exploring the server log files with data techniques. As popularity of has exploded, there is strong desire behavior. However, it difficult perform user-oriented directly on because they tend be ambiguous incomplete. With innovative algorithms, SpeedTracer first identifies sessions reconstructing traversal paths. It does not require “cookies” or registration for session...
The problem of rollback recovery in distributed shared virtual environments, which the memory is implemented software a loosely coupled multicomputer system, examined. A user-transparent checkpointing scheme and new twin-page disk storage management technique are presented for implementing recoverable memory. can be integrated with coherence protocol managing design allows to proceed an incremental fashion without explicit undo at time recovery. system restart computation from checkpoint...
The problem of recovering from processor transient faults in shared memory multiprocessor systems is examined. A user-transparent checkpointing and recovery scheme using private caches presented. Processes can recover errors due to faulty processors by restarting the checkpointed computation state. Implementation techniques checkpoint identifiers stacks are examined as a means reducing performance degradation utilization during normal execution. This cache-based technique prevents rollback...
Activin and inhibin are both dimeric proteins sharing the same β subunits that belong to TGF-β superfamily. They well known for stimulating inhibiting pituitary FSH secretion, respectively, in mammals. In addition, activin also acts as a mesoderm-inducing factor frogs. However, their functions development reproduction of other species poorly defined. this study, we disrupted all three activin/inhibin (βAa, inhbaa ; βAb, inhbab βB, inhbb ) zebrafish using CRISPR/Cas9. The loss βAa/b but not...
Sex determination and differentiation in zebrafish involve a complex interaction of male female-promoting factors. While Dmrt1 has been established as critical male-promoting factor, the roles Anti-Müllerian hormone (Amh) androgen signaling remain less clear. This study employed an estrogen-deficient model (cyp19a1a-/-) to dissect individual combined Amh receptor (Ar) gonadal gametogenesis. Loss amh, but not ar, could rescue all-male phenotype cyp19a1a-/-, leading female or intersex,...
Growth differentiation factor 9 (GDF9) was the first oocyte-specific growth identified; however, most information about GDF9 functions comes from studies in mouse model. In this study, we created a mutant for Gdf9 gene (gdf9-/-) zebrafish using TALEN approach. The loss of caused complete arrest follicle development at primary (PG) stage. These follicles eventually degenerated, and all females gradually changed to males through sex reversal, which could be prevented by mutation male-promoting...
Abstract As a species without master sex-determining genes, zebrafish displays high plasticity in sex differentiation, making it an excellent model for studying the regulatory mechanisms underlying gonadal differentiation and gametogenesis. Despite being gonochorist, is juvenile hermaphrodite that undergoes special phase of ovary before further into functional testis ovary. The formation subsequent remain largely unknown. In this study, we explored role Nobox/nobox (new born homeobox...
H<sub>8</sub>-BINOL-type imidodiphosphoric acid (0.3–2 mol%) catalyzed highly enantioselective aza-Friedel–Crafts reactions of pyrroles and enamides/imines have been developed.
Chiral allenes are important structural scaffolds found in many natural products and drugs, addition, they also serve as building blocks for organic transformations. The conventional methods preparing chiral rely on the resolution of racemic chirality transfer between non-racemic propargylic derivatives nucleophilic reagents. In recent years, synthesis by asymmetric catalysis has been achieved fruitful results. Among them, enantioselective with catalysts is particularly prominent. this...
This study evaluated the effects of sauchinone on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) mice model and investigated underlying mechanisms downstream pathway gut microbiota. The UC was induced by DSS. disease phenotypes were determined through pathological symptoms (body weight activity index score), inflammation markers (histological inflammatory factor detections), colonic mucosal barrier damage (detection tight junction proteins). level NF-κB detected marker...
Abstract FIGLA and NOBOX are important oocyte-specific transcription factors. Both figla-/- nobox-/- mutants showed all-male phenotype in zebrafish due to increased dominance of the male-promoting pathway. The early diversion towards males these has precluded analysis their roles folliculogenesis. In this study, we attenuated pathway by deleting dmrt1 , a key gene, fish, which allows sufficient display defects Germ cells figla-/-;dmrt1 -/- double mutant remained cysts without forming...
Anti-Müllerian hormone (AMH/Amh) plays an important role in gonadal function. Amh deficiency caused severe dysgenesis and dysfunction zebrafish with hypertrophy both sexes. However, its action mechanism remains unknown. Intriguingly, the cognate type II receptor (Amhr2) is missing genome, sharp contrast to other species. Using a series of mutants (amh, fshb, fshr lhcgr), we provided unequivocal evidence for actions via modulating gonadotropin signaling on germ cell proliferation...
The differentiation efficiency of adult stem cells undergoes a significant decline in aged animals, which is closely related to the organ function and age-associated diseases. However, underlying mechanisms that ultimately lead this observed remain largely unclear. This study investigated Drosophila midguts identified an obvious upregulation caudal (cad), encodes homeobox transcription factor. factor traditionally known as central regulator embryonic anterior-posterior body axis patterning....