A5076315776- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- COVID-19 epidemiological studies
- Diagnosis and treatment of tuberculosis
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Adolescent Sexual and Reproductive Health
- SARS-CoV-2 detection and testing
- Infectious Diseases and Tuberculosis
- Cytokine Signaling Pathways and Interactions
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- Viral Infections and Outbreaks Research
- HIV, Drug Use, Sexual Risk
- Neonatal and Maternal Infections
- Vaccine Coverage and Hesitancy
- Nosocomial Infections in ICU
- Hepatitis Viruses Studies and Epidemiology
- Hemoglobinopathies and Related Disorders
- Prenatal Screening and Diagnostics
- vaccines and immunoinformatics approaches
- COVID-19 Impact on Reproduction
- Genomic variations and chromosomal abnormalities
Libreville Hospital
2014-2025
Université des Sciences de la Santé
2014-2025
German Center for Infection Research
2024
Mother Hospital
2023
Laboratoire National de Santé
2015-2021
Omar Bongo University
2021
Weatherford College
2020
National Public Health Laboratory
2014
Inserm
2009-2013
Université Paris Cité
2013
Background: Both T-cell activation during early HIV-1 infection and soluble markers of immune chronic are predictive HIV disease progression. Although the acute phase is associated with increased pro-inflammatory cytokine production, relationship between concentrations pathogenesis unknown. Objectives: To identify biomarkers measurable in plasma that predict Design: Study including 40 South African women who became infected were followed longitudinally from time infection. Methods: The 30...
The recent introduction of fluorescent bead-based technology, allowing the measurement multiples analytes in a single 25–50 µl sample has revolutionized study cytokine responses. However, such multiplex approaches may compromise ability these assays to accurately measure actual levels. This evaluates performance three commercially available immunoassays (Bio-Rad's Cytokine 17-plex kit; LINCO Inc's 29-plex and RnD System's Fluorokine-Multi Analyte Profiling (MAP) base kit A B). Inc was found...
Summary Biomarkers for treatment response would facilitate the testing of urgently needed new anti-tuberculous drugs. The present study investigated profiles 30 proinflammatory, anti-inflammatory and angiogenic factors [epidermal growth factor, eotaxin, fractalkine, granulocyte colony-stimulating granulocyte–macrophage interleukin (IL)-1α, IL-1β, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12p40, IL-12p70, IL-13, IL-15, IL-17, interferon-γ, interferon-inducible protein-10, Krebs...
Biomarkers for TB treatment response and outcome are needed. This study characterize changes in immune profiles during treatment, define biosignatures associated with outcomes, explore the feasibility of predictive models relapse. Seventy-two markers were measured by multiplex cytokine array serum samples from 78 cured, 12 relapsed 15 failed patients South Africa before therapy pulmonary TB. Promising evaluated a second cohort Uganda/Brazil consisting 17 relapse 23 cured patients. Thirty...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has emerged throughout the world. Building knowledge around Covid‐19 is crucial to devise facts based approaches respond efficiently against this pandemic. Aim We aimed investigate pre‐existing humoral cross‐reactive immunity SARS‐CoV‐2. Method have tested reactivity SARS‐CoV‐2 nucleocapsid (N) antigen of sera collected from healthy healthcare volunteers in 2014. assessed immunoglobulins reactive N‐antigen using...
SummaryBackgroundThe present study is one of the first to provide a picture antimicrobial resistance for range bacteria and classes in Gabon, Central Africa.MethodsDuring year 2010, 146 urine cytology, 143 blood cultures, 107 vaginal swabs, 23 urethral 18 other culture examinations were positives. All isolates tested antibiotic sensitivity.ResultsFour hundred thirty-seven microorganisms isolated: 210 enterobacteria, 166 staphylococci, 38 streptococci, 14 Acinetobacter, nine Stenotrophomonas....
This study investigated interleukin-4 (IL-4), IL-4 delta 2, transforming growth factor beta (TGF-beta), TGF-beta RII, Foxp3, GATA-3, T-bet, and gamma interferon (IFN-gamma) transcription in peripheral blood samples of adult pulmonary tuberculosis patients prior to after 1 week therapy. Twenty with positive results for sputum culture Mycobacterium were enrolled treated directly observed short-course antituberculosis chemotherapy. Early treatment response was assessed. At the end intensive...
Blood transfusions carry the risk of transmitting blood-borne infections. In contrast to situation in developed world, there is a limited number studies examining this problem sub-Saharan Africa. study we aimed calculate risks acquiring human immunodeficiency virus (HIV), hepatitis B (HBV), and C (HCV) infection from units blood issued by Gabonese Transfusion Centre between 2009 2011.All donations were tested for infectious diseases seroconversion incidence rates HIV, HBV HCV calculated. The...
Tuberculosis (TB) remains a public health concern worldwide, affecting millions of people every year. Detailed characterization disease pathophysiology is key to proper diagnosis, progression, or treatment follow-up and evaluation. The present study investigated C-reactive protein Procalcitonin (PCT) as candidate markers early response activity.
Seroconversion surveys of anti-SARS-CoV-2 antibodies provide accurate estimates the SARS-CoV-2 infection. This nationwide population-based cross-sectional serosurvey aimed to evaluate prevalence among residents in Gabon and compare estimated cumulative number COVID-19 cases with officially registered laboratory-confirmed up December 2021. Households each province were randomly selected. Twenty-eight localities including 16 urban 12 rural, selected participate study. Whole blood samples...
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (TB) constitute a major public health concern.To determine the timing pncA mutations that confer pyrazinamide (PZA) resistance in relation to conferring isoniazid (INH) rifampicin (RMP).Isolates from two urban centres--Paris (101 strains) Shanghai (171 strains)--were investigated for association with drugs other than PZA.The proportion found INH-monoresistant was not increased.pncA associated...
To evaluate the phytochemical constituents, antioxidant and antimicrobial potential of water-acetone, water-ethanol water extracts Coula edulis (C. edulis), Pseudospondia longifolia (P. longifolia) Carapa klaineana klaineana). Presence total phenols, flavonoids, tannins proanthocyanidins was evaluated to estimate effects plants on microbial diseases. Water-acetone, were examined for activities. All plant against six reference strains, eleven clinical isolates two fungal strains. The contents...
ABSTRACT Multidrug-resistant (MDR) and extensively drug resistant (XDR) strains of Mycobacterium tuberculosis pose major problems for global health. The GeneXpert MTB/RIF (Xpert) assay rapidly detects resistance to rifampin (RIF r ), but detection the additional that defines MDR-TB (MDR tuberculosis) XDR-TB, molecular epidemiology, specimen cultures a biosafe infrastructure are generally required. We sought determine whether remnants sputa prepared Xpert could be used directly find mutations...
Chrysophyllum pruniforme of family sapotaceae is a plant used in traditional medicine Gabon.In this study, C. barks were subjected to phytochemical screening and cytotoxicity investigations. Different concentrations aqueous total phenolic extract tested on mice human erythrocytes.Phytochemical revealed the presence flavonoids, saponins, tannins, reducing sugars, polyphenols traces anthraquinones. When vitro, extracts showed hemolytic activities erythrocytes with compounds being more...
Abstract In a context where SARS-CoV-2 population-wide testing is implemented, clinical features and antibody response in those infected have never been documented Africa. Yet, the information provided by analyzing data from critical to understand infection dynamics devise control strategies. We described assessed people screened for infection. analyzed cohort of 3464 that we molecularly our routine activity. recorded diagnosis, age, gender, blood types, white cells (WBC), symptoms, chronic...
ObjectiveVariants of concern (VOCs) associated with relatively high transmissibility appear to be rapidly spreading in Gabon. Therefore, it is imperative understand the distribution several VOCs population, which could have implications for and vaccine efficacy.MethodsBetween February May 2021, SARS-CoV-2 genomes were sequenced using Oxford nanopore MinION method respective genome diversity was elucidated. Phylogenetic analysis performed classified pangolin lineages.ResultsThe results...