A5005907099- Malaria Research and Control
- Mosquito-borne diseases and control
- Vector-borne infectious diseases
- Parasites and Host Interactions
- Viral Infections and Vectors
- Child Nutrition and Water Access
- Global Maternal and Child Health
- Phytochemicals and Antioxidant Activities
- SARS-CoV-2 and COVID-19 Research
- Complement system in diseases
- Aquaculture disease management and microbiota
- Calpain Protease Function and Regulation
- SARS-CoV-2 detection and testing
- Vibrio bacteria research studies
- Yersinia bacterium, plague, ectoparasites research
- Ginkgo biloba and Cashew Applications
- Iron Metabolism and Disorders
- COVID-19 Clinical Research Studies
- Phytochemistry and Biological Activities
- HIV Research and Treatment
- Diverse Scientific Research Studies
- Dermatological diseases and infestations
- Travel-related health issues
Centre International de Recherches Médicales de Franceville
2015-2025
Libreville Hospital
2021
Abstract Background Asymptomatic infections by Anaplasma spp. and the basis of immune response during these have not yet been established. This study investigated inflammatory cytokine responses infection in school children effect co-infection with Plasmodium spp . helminths. Methods Blood stool samples were taken from aged 5 to 17 years. Parasitological diagnosis was carried out RDT microscopy, while microscopy PCR used diagnose Plasma for assays using ELISA technique. Results A total 219...
Background: Urogenital schistosomiasis is endemic in Gabon. Our study aimed to detect the prevalence of urinary and evaluate diagnostic performance qPCR technique compared microscopy for detection Schistosoma haematobium at community level a semi-rural area. Method: A cross-sectional survey was carried out. Urine samples were examined using TICK test strips, filtration technique, qPCR. detected by targeting Dra1 gene. Results: The urogenital determined real-time PCR urine strips with that...
Abstract Background Malaria is the most deadly parasitic disease and continues to claim more than a half million of deaths across world each year, mainly those under-fives children in sub-Saharan Africa. The aim this study was determine epidemiological, clinical laboratory features patients with severe malaria at Centre Hospitalier Régional Amissa Bongo (CHRAB), referral hospital Franceville. Methods It an observational descriptive conducted CHRAB over 10 months. All admitted emergency ward...
Rickettsia felis has been reported to be a cause of fever in sub-Saharan Africa, but this association poorly evaluated Gabon. We assessed the prevalence bacterium among children <15 years age 4 areas Gabon; locations were urban, semiurban, and rural areas. DNA samples from 410 febrile 60 afebrile analyzed by quantitative PCR. Overall, R. was 10.2% (42/410 children) 3.3% (2/60 children), respectively. Prevalence differed living that are urban (Franceville, 1.3% [1/77]), semiurban...
In Gabon, a new national malaria control policy was implemented in 2003. It resulted decrease the number of cases country. March 2020, disruption routine health services due to COVID-19 pandemic has led an increase and deaths malaria. However, Franceville, south-east no data on recorded before, during after epidemic been published. Thus, objective this study determine epidemiological characteristics Franceville from 2019 2021.A retrospectively performed at Hôpital de l'Amitié Sino-Gabonaise...
Control strategies implemented a decade ago led to marked reduction in the prevalence of malaria many countries. In Dienga, southeastern Gabon, microscopic P. falciparum infection was 7% 2003, close pre-elimination threshold 5%. The aim this work determine same community later. A cohort 370 individuals aged from 3 85 years living Dienga investigated for infection; during six passages (P) 15-month period. Demographic data were collected, along with behaviors and attitudes towards malaria....
Abstract In a context where SARS-CoV-2 population-wide testing is implemented, clinical features and antibody response in those infected have never been documented Africa. Yet, the information provided by analyzing data from critical to understand infection dynamics devise control strategies. We described assessed people screened for infection. analyzed cohort of 3464 that we molecularly our routine activity. recorded diagnosis, age, gender, blood types, white cells (WBC), symptoms, chronic...
Evaluating malaria control strategies for pregnant women is essential. The objective of this study was to determine the factors influencing antenatal care (ANC) visit attendance, complete intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) and its impact on health their newborn babies living in semi-urban rural areas southeastern Gabon.This transversal performed at Centre Hospitalier Régional Paul Moukambi de Koula-Moutou (CHRPMK). Information regarding age, frequency...
Plasmodium falciparum infection can progress unpredictably to severe forms including respiratory distress and cerebral malaria. The mechanisms underlying the variable natural course of malaria remain elusive. microvascular endothelial cells-D3 lung cells both from human were cultured separately challenged with P. field isolates taken directly patients or 3D7 strain (in vitro maintained culture). capacity these induce cell apoptosis via cytoadherence not was then assessed. Overall, 27...
Due to the difficulty of obtaining blood samples, which is invasive method that currently used for detection Plasmodium spp., alternative diagnostic sampling methods are effective and non-invasive needed, particularly long-term studies. Saliva stool samples from malaria-infected individuals contain trace amounts DNA therefore could be as alternatives. Malaria was screened using rapid diagnosis tests confirmed via microscopy. Nested PCR targeting falciparum-specific STEVOR gene were performed...
Oxidative stress and inflammation play a key role in the occurrence of neurodegenerative diseases. Traditionally, Pentaclethra eetveldeana leaves are used dementia treatment. Therefore, this study aimed to evaluate antioxidant anti-inflammatory activities as well phytochemical composition from four Congo-Brazzaville regions. The 1.2-diphenyl-1-picrylhydrazyl radical-scavenging, β-carotene bleaching molybdenum reduction assays were assess activity. protein denaturation erythrocyte membrane...
La détection des parasites responsables du paludisme se fait par microscopie ou tests de diagnostic rapide mais ces techniques ne permettent pas détecter tous les cas d’infection. L'adoption moléculaires pour la P. falciparum a révélé, présence nombreuses infections faible densité indétectables routine et pourtant transmissibles. Dans cette revue, nous avons analysé, situation actuelle submicroscopiques discuter ; leurs intérêts, dans le développement stratégies lutte, visant à éliminer...
Plasmodium falciparum merozoite antigens (PfMAgs) play an essential role in the development of immunity to malaria. Currently, P. falciparum: protein 113 (Pf 113), apical membrane antigen 1 (AMA1), erythrocyte binding (EBA175), and reticulocyte homologue 5 (RH5) are among most PfMAgs studied. A comparative analysis naturally acquired antibodies against these children would increase our knowledge about protective immunity. Analysis Pf113, PfAMA1, PfEBA175, PfRH5 was conducted rural population...
In Gabon, located in West-
Background: Malaria remains the deadliest parasitic disease and continues to cause more than half a million deaths across world each year, mainly victims are sub-Saharan children. is common reason for paediatric hospitalisation. Objective: The objective was characterise malaria describe evolution after treatment in department of University Hospital Centre Amissa Bongo de Franceville. Methods: This cross-sectional study conducted from 1 February 2023 15 May 2023. A clinical biological...
A better understanding of malaria epidemiology in both asymptomatic and symptomatic individuals is essential for developing strategies to control the disease. This study was conducted determine
Abstract Background Malaria is the most deadly parasitic disease and continues to claim more than a half million of deaths across world each year, mainly those under-fives children in sub-Saharan Africa. The aim this study was determine epidemiological, clinical laboratory features patients with severe malaria at Centre Hospitalier Régional Amissa Bongo (CHRAB), referral hospital Franceville. Method It an observational descriptive conducted CHRAB over ten months. All admitted emergency ward...
Abstract Background: Evaluating malaria control strategies for pregnant women is essential. The objective of this study was to determine the factors influencing frequency prenatal consultations (PNC), adherence intermittent preventive treatment with sulfadoxine-pyrimethamine (IPT-SP) and its impact on health parturient their newborn babies living in semi-urban rural areas southeastern Gabon. Methods: This transversal performed at Centre Hospitalier Régional Paul Moukambi de Koula-Moutou...