A5019329198- Antibiotic Resistance in Bacteria
- Neonatal and Maternal Infections
- Antibiotic Use and Resistance
- Global Maternal and Child Health
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Clostridium difficile and Clostridium perfringens research
- Enterobacteriaceae and Cronobacter Research
- Escherichia coli research studies
- Sepsis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Child Nutrition and Water Access
- Urinary Tract Infections Management
- Pneumonia and Respiratory Infections
- Legionella and Acanthamoeba research
- Neonatal skin health care
- Indoor Air Quality and Microbial Exposure
- Pharmaceutical and Antibiotic Environmental Impacts
- COVID-19 and healthcare impacts
- Antifungal resistance and susceptibility
- Leptospirosis research and findings
- Antimicrobial agents and applications
- Listeria monocytogenes in Food Safety
- Nosocomial Infections in ICU
- SARS-CoV-2 detection and testing
Children's Hospital of Philadelphia
2021-2024
University of Botswana
2021-2024
University of Pennsylvania
2023-2024
Chulalongkorn University
2022
Centers for Disease Control and Prevention
2019-2021
Waterborne Environmental (United States)
2021
Epidemic Intelligence Service
2019-2021
National Center for Emerging and Zoonotic Infectious Diseases
2019-2021
Texas Department of State Health Services
2020
World Health Organization - Zimbabwe
2020
Abstract Invasive Cronobacter infections among infants are associated with severe neurologic disabilities and death. Early reports typically featured hospitalized preterm recognized contaminated powdered infant formula (PIF) as a transmission vehicle. To clarify recent epidemiology, we reviewed all cases of bloodstream infection or meningitis that were reported to the Centers for Disease Control Prevention in literature (1961–2018; n = 183). Most neonates (100/150 [67%]); 38% (42/112) died,...
Abstract To our knowledge, environmental isolation of Burkholderia pseudomallei, the causative agent melioidosis, from continental United States has not been reported. We report a case melioidosis in Texas resident. Genomic analysis indicated that isolate groups with B. pseudomallei isolates patients same region, suggesting possible endemicity to this region.
On October 16, 2017, after identifying a suspected typhoid fever case in resident of Mbare suburb Harare, Zimbabwe, the city health department investigated further and, as February 24, 2018, had identified total 3,187 cases.
In August 2017, Hurricane Harvey caused unprecedented flooding and devastation to the Houston metropolitan area (1). Mold exposure was a serious concern because investigations after Hurricanes Katrina Rita (2005) had documented extensive mold growth in flood-damaged homes (2,3). Because can cause illnesses known as invasive infections (4,5), immunosuppressed persons are at high risk for these (6,7), several federal agencies recommend that avoid mold-contaminated sites (8,9). To assess extent...
Abstract Introduction Infections due to extended spectrum beta-lactamase producing organisms (ESBL) have emerged as the leading cause of sepsis among hospitalized neonates in Botswana and much sub-Saharan Africa south Asia. Yet, ESBL reservoirs transmission dynamics within neonatal intensive care unit (NICU) environment are not well-understood. This study aimed assess efficiency feasibility a chromogenic-culture-media-based environmental sampling approach characterize bioburden NICU. Methods...
Following Hurricanes Irma and Maria, the first case of human leptospirosis ever identified in US Virgin Islands (USVI) was reported to Department Health. Leptospirosis is a potentially fatal bacterial disease caused by Leptospira species found animal urine urine-contaminated water soil. Outbreaks can occur following extreme weather events.Additional cases were 2.5 months post-hurricanes reviewing emergency department (ED) records from territorial hospitals for patients demonstrating...
We report a fatal case of SARS-CoV-2 and Mycobacterium tuberculosis coinfection in an infant, Botswana’s first paediatric COVID-19-associated fatality. The patient, 3-month-old HIV-unexposed boy, presented with fever respiratory distress the setting failure to thrive. Both patient his mother tested positive for rifampin-sensitive M. (Xpert MTB/Rif) (real time-PCR). Initially stable on supplemental oxygen antitubercular therapy, experienced precipitous clinical decline 5 days after...
ABSTRACT Sepsis is the leading postnatal cause of neonatal mortality worldwide. Globally Klebsiella pneumoniae sepsis in hospitalized neonates. This study reports development and evaluation ELISA for anti- IgG using dried blood spot samples evaluates association (anti-Kleb IgG) antibodies maternal risk sepsis. Neonates their mothers were enrolled at 0-96 hours life unit a tertiary referral hospital Gaborone, Botswana followed until death or discharge to assess episodes culture-confirmed with...
Shigella infections are an important cause of diarrhea in young children and can result severe complications. Disparities well documented among US adults. Our objective was to characterize disparities incidence severity children.We analyzed laboratory-diagnosed reported FoodNet, active, population-based surveillance system 10 sites, during 2009-2018. We calculated the rate stratified by sex, age, race/ethnicity, species, disease severity. Criteria for classification were hospitalization,...
Abstract Background In 2018, the Centers for Disease Control and Prevention Vermont Department of Health investigated an outbreak multidrug-resistant Shigella sonnei infections in a retirement community that offered continuum care from independent living through skilled nursing care. The investigation identified 24 culture-confirmed cases. Isolates were resistant to trimethoprim-sulfamethoxazole, ampicillin, ceftriaxone, had decreased susceptibility azithromycin ciprofloxacin. Methods To...
Infection prevention challenges are ubiquitous in healthcare, but some unique to or more prevalent low-and middle-income country settings. Despite limited resources, innovative and committed paediatric healthcare providers infection preventionists have found creative solutions address the very real pressing risks their patients face every day. We gathered examples of control faced by clinicians resource-limited facilities, real-world they implemented, with goal learning broader lessons...
Abstract Background Medical devices are critical to providing high-quality, hospital-based newborn care, yet many of these unavailable in low- and middle-income countries (LMIC) not designed be suitable for settings. Target Product Profiles (TPPs) often utilised at an early stage the medical device development process enable user-defined performance characteristics a given setting. TPPs can also applied assess profile match existing context. Methods We developed initial 15 product categories...
A 2018 cholera outbreak in Zimbabwe underscored the importance of community-wide water, sanitation, and hygiene interventions, as well vaccination detection reducing cholera's impact.
We describe a cluster of six SARS-CoV-2 infections occurring in crowded neonatal unit Botswana, including presumed transmission among mothers, postnatal mother-to-neonate and three neonate-to-healthcare worker transmissions. The affected neonate, born at 25 weeks’ gestation weighing 785 g, had positive test 3 weeks age which coincided with new onset hypoxaemia worsening respiratory distress. Because no isolation facility could accommodate both patient mother, they were separated for 10 days,...
Background: Multidrug-resistant Gram-negative bacteria are a major cause of sepsis among hospitalized neonates globally. Aqueous chlorhexidine gluconate (CHG) skin antisepsis has been shown to be safe for use in infants; however, its sustained effectiveness preventing pathogen colonization, bloodstream infection (BSI), and mortality is unclear. Methods: We conducted period prevalence survey, with 26 sampling events over 12 months (18 October 2022 – 31 2023) at 33-bed neonatal unit tertiary...
Sepsis is the leading postnatal cause of neonatal mortality worldwide. Globally Klebsiella pneumoniae sepsis in hospitalized neonates. This study reports development and evaluation an ELISA for anti- IgG using dried blood spot (DBS) samples evaluates association (anti-Kleb IgG) antibodies maternal with risk sepsis. Neonates their mothers were enrolled at 0–96 hours life unit a tertiary referral hospital Gaborone, Botswana followed until death or discharge to assess episodes culture-confirmed...
Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major cause of bloodstream infection among hospitalized patients in low- and middle-income countries (LMICs). CRAB infections can be difficult to treat are devastating neonates (~30% mortality). outbreaks hypothesized arise from reservoirs the hospital environment, but outbreak investigations LMICs seldom incorporate whole-genome sequencing (WGS). Methods: WGS (Illumina NextSeq) was performed at National...