A5100448263- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Fungal Infections and Studies
- Metabolism, Diabetes, and Cancer
- T-cell and B-cell Immunology
- Viral Infectious Diseases and Gene Expression in Insects
- Autoimmune Neurological Disorders and Treatments
- Neurobiology and Insect Physiology Research
- Adipose Tissue and Metabolism
- Antifungal resistance and susceptibility
- HIV Research and Treatment
- RNA modifications and cancer
- Animal Virus Infections Studies
- Plant Disease Resistance and Genetics
- Muscle Physiology and Disorders
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Mesenchymal stem cell research
- Invertebrate Immune Response Mechanisms
- Fungal Biology and Applications
- Diet, Metabolism, and Disease
- Exercise and Physiological Responses
Ludong University
2024-2025
Benaroya Research Institute
2016-2020
Second Military Medical University
2019
Changhai Hospital
2019
Yuhuangding Hospital
2017-2018
Qingdao University
2018
University of Washington
1995-2015
Southern Medical University
2012-2014
Zhujiang Hospital
2014
Zhejiang University
2010
We aimed to describe the natural history of residual insulin secretion in Type 1 Diabetes TrialNet participants over 4 years from diagnosis and relate this previously reported alternative clinical measures reflecting β-cell secretory function.Data 407 subjects 5 intervention studies were analyzed. All had baseline stimulated C-peptide values ≥0.2 nmol/L mixed-meal tolerance tests (MMTTs). During semiannual visits, MMTTs, HbA1c, doses obtained.The percentage individuals with or detectable...
BACKGROUNDResidual C-peptide is detected in many people for years following the diagnosis of type 1 diabetes; however, physiologic significance low levels detectable not known.METHODSWe studied 63 adults with diabetes classified by peak mixed-meal tolerance test (MMTT) as negative (<0.007 pmol/mL; n = 15), (0.017-0.200; 16), intermediate (>0.200-0.400; or high (>0.400; 17). We compared groups' glycemia from continuous glucose monitoring (CGM), β cell secretory responses a glucose-potentiated...
Mehta VK, Hao W, Brooks-Worrell BM, Palmer JP. Low-dose interleukin 1 and tumor necrosis factor individually stimulate insulin release but in combination cause suppression. Eur J Endocrinol 1994;130:208–14. ISSN 0804–4643 The macrophage-derived cytokines (IL-1) (TNF) have direct effects on pancreatic beta cells been hypothesized to play important roles the autoimmune cell lesion of type I diabetes because two major cells: altered secretion cytotoxicity. High doses IL-1 are cytotoxic strongly...
The purpose of this study was to investigate the underlying molecular mechanisms fracture healing mediated by bone marrow mesenchymal stem cells. Differentially expressed microRNAs in acutely injured subjects and healthy volunteers were screened microarray analysis. dual luciferase reporter system used verify whether insulin-like growth factor 1 (IGF1) direct target gene regulated miR-148a. expression level miR-148a IGF1 after osteogenic differentiation detected quantitative real-time...
Decades of studies demonstrate that ∼50% risk for type 1 diabetes (T1D) is heritable (1). The first loci linked to T1D were the HLA genes have largest effect size any susceptibility locus, followed by linkage insulin VNTR (2,3). Linkage given way genome-wide association (GWAS) identified >50 contribute developing (4). Most these impart modest relative (odds ratio ≤2.0) and together with account ∼80% heritability (5). question remains: GWAS delivered in terms our ability understand causes...
There is little information regarding β cell mass in individuals at early stages of type 1 diabetes (T1D). To investigate both acute insulin response to arginine hyperglycemia (AIRmax), as a correlate mass, and function by the intravenous glucose tolerance test (IVGTT) subjects T1D. Forty were enrolled: (1) low-risk group: relatives patients with T1D 0 antibody (n = 21) (2) high-risk ≥2 antibodies 19). Acute C-peptide responses IVGTT AIRmax. Participants underwent two AIRmax procedures on...
7‐11 November 2010, Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK
OBJECTIVE To investigate the effect of parenteral insulin therapy on endogenous secretion in Diabetes Prevention Trial–Type 1 (DPT-1). RESEARCH DESIGN AND METHODS In arm DPT-1, subjects without diabetes at high risk future type randomized to active treatment received a yearly 4-day intravenous infusion (IV-I) and daily subcutaneous (SC-I). examine effects these therapies secretion, C-peptide glucose levels were compared during oral tolerance tests (OGTTs) performed off IV-I SC-I. Forty-six...
Background: Glutamic acid decarboxylase-65 (GAD65), the enzyme that catalyzes formation of gamma-aminobutyric (GABA), is major autoantigen in both type 1 (insulin-dependent) diabetes and stiff-man syndrome (SMS). The observation GAD65 autoantibodies may be present for years before clinical onset raises question when available to initiate an immune response allow autoantibodies. In order address this it will necessary measure tissue, cells, plasma. Methods: A radioimmunoassay (RIA) was...
Recent work from one laboratory has shown, in both nonobese diabetic mice and humans, an association between insulin-dependent diabetes mellitus (IDDM) quantitative difference MHC class I molecule expression. This reported decrease expression is very controversial the mouse model of IDDM, but to our knowledge, it not been evaluated by another group human IDDM. To evaluate this question, we studied 30 patients with IDDM age- sex-matched normal controls. was measured flow cytometry...
The macrophage-derived cytokine, interleukin-1β (IL-1β), has been implicated to play an important role in the autoimmune β cell lesion of insulin-dependent diabetes mellitus (IDDM) because its inhibition insulin secretion, direct cytotoxicity, and alteration islet antigen expression. Because transforming growth factor (TGF-β) reported inhibit IL-1 receptor expression several lymphoid progenitor lines, induce antagonist protein (IRAP) production human peripheral blood monocytes, antagonize...
The onset of atopic dermatitis (AD) is complex, and its specific pathological mechanisms have not yet been fully elucidated.
G protein alpha q subunit (Gαq) can binds to the protein-coupled receptor (GPCR) for signaling and is closely related lipid metabolism. Endurance exercise an effective means of combating acquired obesity its complications, but mechanisms by which endurance modulates hereditary complications are unknown. In this study, we achieved knockdown Gαq in drosophila adipose tissue skeletal muscle constructing Gαq-UAS-RNAi/Ppl-Gal4 Gαq-UAS-RNAi/Mef2-GAl4 systems. Drosophila were subjected a three-week...
Insulin dependent diabetes mellitus (IDDM) is an autoimmune disease characterized by lymphocytic infiltration of the pancreatic islets (insulitis). Cytokines released as part insulitis process have been suggested to play important role in beta cell lesion IDDM. A possible diabetogenic effect cytokines may be mediated their inducing abnormal expression islet autoantigens. Since glutamic acid decarboxylase-65 (GAD-65) a target autoantigen IDDM, we investigated whether IL-1 beta, TNF alpha IFN...
Objective To evaluate in vivo magnetic resonance imaging (MRI) for tracking the magnetically labeled human bone marrow-derived mesenchymal stem cells (hBMSCs) which sliencing of cyclooxygenase-2 (COX-2) transplanted into nude rat through tail vein injection. Methods In present study, we knockdown COX-2 hBMSCs by lentivirus infection, detected expression reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting. Then with new superparamagnetic iron oxide...
Summary We previously assessed the kinetics of T cell turnover in vivo by labeling cells with 2H-H2O over 42 days individuals type 1 diabetes (T1D) and demonstrated an increased CD4 memory cells. have now tested at risk for T1D using a 3–4-day protocol 2H-glucose. studied 30 relatives without autoantibodies, 10 healthy controls. Peripheral blood mononuclear (PBMC) were flow-sorted into subsets interest; 2H-DNA enrichment was measured mass spectrometry in-vivo calculated as maximum fractional...