A5056753372- Vibrio bacteria research studies
- COVID-19 epidemiological studies
- Influenza Virus Research Studies
- Salmonella and Campylobacter epidemiology
- Vaccine Coverage and Hesitancy
- Respiratory viral infections research
- Escherichia coli research studies
- COVID-19 Pandemic Impacts
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Neonatal Respiratory Health Research
- Natural Language Processing Techniques
- Blood donation and transfusion practices
- Topic Modeling
- Explainable Artificial Intelligence (XAI)
- Data-Driven Disease Surveillance
- Food Security and Health in Diverse Populations
Johns Hopkins University
2021-2025
Yale University
2024-2025
First Hospital of Shijiazhuang
2015
BackgroundA global shortage of cholera vaccines has increased the use single-dose regimens, rather than standard two-dose regimen. There is sparse evidence on protection, particularly in children. In 2020, a mass vaccination campaign was conducted Uvira, an endemic urban setting eastern Democratic Republic Congo, resulting largely coverage. We examined effectiveness oral vaccine Euvichol-Plus this high-burden setting.MethodsIn matched case-control study, we recruited individuals with...
BackgroundMaximizing the impact of limited global supply killed oral cholera vaccines (kOCVs) requires understanding barriers to achieving high population coverage during vaccination campaigns as well factors that may influence declines over time. In 2020, two rounds mass with Euvichol-Plus were conducted in Uvira The Democratic Republic Congo. We used data from three serial cross-sectional representative surveys between 11 and 33 months after to:(i) estimate post-vaccination campaign...
Abstract Background Multiple prophylactic products are now available to protect against respiratory syncytial virus (RSV) in different age groups. Assessing the pre-intervention burden of RSV infections across various severity levels and risk groups is crucial, as it provides a baseline for evaluating impact these products. Methods We obtained monthly time series data on hospitalizations, intensive care unit (ICU) admissions, deaths by group, ZIP code, cause New York state from 2005 2019....
Background We conducted three serial cross-sectional representative surveys after a mass cholera vaccination campaign in Uvira, Democratic Republic of the Congo to (1) estimate coverage and explore heterogeneity by geographic demographic factors; (2) examine barriers facilitators vaccine uptake (3) describe changes over time predict future coverage. Methods collected data on sociodemographics, self-reported status, population movement knowledge, attitudes behaviours related killed oral...
IMPORTANCE Nirsevimab, a long-acting monoclonal antibody, demonstrated efficacy against respiratory syncytial virus (RSV)–associated lower tract infections (LRTI) in clinical trials. Postlicensure monitoring is essential to confirm these benefits settings. OBJECTIVE To estimate the effectiveness of nirsevimab medically attended RSV infants and assess how varies by disease severity, dosage, time since immunization. DESIGN, SETTING, AND PARTICIPANTS This test-negative case-control study...
Systematic testing for Vibrio cholerae O1 is rare, which means that the world's limited supply of oral cholera vaccines (OCVs) may not be delivered to areas with highest true burden. Here we used a phenomenological model subnational geographic targeting and fine-scale vaccine effects how expanding V. affected impact cost-effectiveness preventive vaccination campaigns across different bacteriological confirmation assumptions in 35 African countries. followed by OCV based on confirmed yielded...
Background The United States of America has the highest global number COVID-19 cases and deaths, which may be due in part to delays inconsistencies implementing public health social measures (PHSMs). Objective In this descriptive analysis, we analyzed epidemiological evidence for impact PHSMs on transmission compared these data those 10 other countries varying income levels, population sizes, geographies. Methods We PHSM implementation timing stringency against daily case counts Canada,...
Our understanding of the burden and drivers cholera mortality is hampered by limited surveillance confirmation capacity. Leveraging enhanced clinical laboratory in cholera-endemic community Uvira, eastern Democratic Republic Congo, we describe deaths across 3 epidemics between September 2021 2023 following mass vaccination.
The enteric pathogens causing diarrhoea impair children's health severely. This study retrospectively analysed 1577 isolated from inpatients and outpatients in six hospitals located Northern (Inner Mongolia), Northeastern (Hebei), Eastern (Shanghai Jiangsu), Southern (Hainan) Central (Hubei) China between 2008 2013. Of the pathogens, Salmonella presented with highest frequency (36·0%), followed by diarrhoeagenic Escherichia coli (23·7%), Staphylococcus aureus (15·0%), Shigella (13·1%),...
In response to COVID-19, governments worldwide are implementing public health and social measures (PHSM) that substantially impact many areas beyond health. The new field of PHSM data science collects, structures, disseminates on PHSM; here, we report the main achievements, challenges, focus this novel research.
Nirsevimab, a long-acting monoclonal antibody, has demonstrated efficacy against RSV-related lower respiratory tract infections (LRTIs) in clinical trials. Post-licensure monitoring is essential to confirm these benefits real-world settings.
Abstract Our understanding of the burden and drivers cholera mortality is hampered by limited surveillance confirmation capacity. Leveraging enhanced clinical laboratory in cholera-endemic community Uvira, eastern Democratic Republic Congo, we describe deaths across three epidemics between September 2021-September 2023, following mass vaccination.
Abstract Background A global shortage of cholera vaccines has increased the use single-dose regimens, rather than standard two-dose regimen. There is limited evidence on protection, particularly in children. In 2020, a mass vaccination campaign resulting largely single dose coverage, was conducted Uvira, an endemic urban setting eastern Democratic Republic Congo. We examined effectiveness oral vaccine Euvichol-Plus ® this high-burden setting. Methods recruited medically attended confirmed...
Abstract Systematic testing for Vibrio cholerae O1 is rare, which means that the world’s limited supply of oral cholera vaccines may not be delivered to areas with highest true burden. We modeled how expanding V. affected vaccine impact and cost-effectiveness across different bacteriological confirmation targeting assumptions. yielded higher efficiency slightly fewer averted cases than status quo scenarios suspected cholera. With a 10 per 10,000 incidence rate threshold, 10.3 (95% PI:...
<sec> <title>BACKGROUND</title> The United States of America has the highest global number COVID-19 cases and deaths, which may be due in part to delays inconsistencies implementing public health social measures (PHSMs). </sec> <title>OBJECTIVE</title> In this descriptive analysis, we analyzed epidemiological evidence for impact PHSMs on transmission compared these data those 10 other countries varying income levels, population sizes, geographies. <title>METHODS</title> We PHSM...