The effect of highly active antiretroviral therapy (HAART) on the survival HIV-infected children has not been well quantified. Because most pediatric HIV occurs in low- and middle-income countries, our objective was to provide a first estimate this among living resource-deprived setting.

Abstract As access to HIV/AIDS treatment increases in sub-Saharan Africa, greater attention is being paid HIV-infected youth. Little known about how HIV-positive youth are informed of their HIV infection. part a larger formative study informing program Kinshasa, Democratic Republic the Congo, semi-structured interviews were conducted with 19 (10–21 years) who had previously been told status and 21 caregivers disclosed youth's Questions explored caregivers' experiences immediate reactions...

Despite the need for HIV-positive children to adhere effectively antiretroviral treatment (ART), a guiding theory pediatric ART in resource-limited settings is still missing. Understanding factors that influence adherence critical developing adequate strategies. In-depth qualitative interviews were undertaken Kinshasa, Democratic Republic of Congo, with 20 sets HIV disclosed and nondisclosed along respective caregivers better characterize barriers, facilitators, experiences taking ART....

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Background We aimed to estimate the effect of anti-retroviral therapy (ART) on incident tuberculosis (TB) in a cohort HIV-infected children. Methods analysed data from ART-naïve, TB disease-free children enrolled between December 2004 and April 2008 into an HIV care program Kinshasa, Democratic Republic Congo. To ART incidence while accounting for time-dependent confounders affected by exposure, Cox proportional hazards marginal structural model was used. Results 364 contributed 596.0...

We aimed to describe factors associated with mortality among children receiving antiretroviral treatment (ART) at a pediatric hospital in Kinshasa, Democratic Republic of the Congo.Two hundred ninety-nine children, <18 years old, were followed for median 77 weeks (interquartile range: 61-103) post-ART initiation. Survival probability was 89.6% [95% confidence interval (CI): 85.5-92.6%] 12 months; 24 31 deaths (77.4%) occurred within 2 months ART Predictors bivariate analysis >/=2...

There is limited information on knowledge, perceptions, and management of sickle cell disease (SCD) in Africa general the Democratic Republic Congo (DRC) particular. This study explored burden 26 parents/caregivers children with SCD three selected hospitals Kinshasa, DRC. We conducted a focus group in-depth interviews affected SCD. Four themes were discussed, including knowledge diagnosis management, society's psychosocial quality life family by The majority participants/caregivers felt that...

Background: The long-term effects of combined antiretroviral therapy (cART) on CD4 percentage in HIV-infected children are incompletely understood, with evidence from resource-deprived areas particularly scarce even though most HIV live such settings. We sought to describe this relationship. Methods: Observational longitudinal data cART-naive enrolled between December 2004 and May 2010 into an care treatment program Kinshasa, Democratic Republic Congo were analyzed. To estimate the effect...

Several approaches to the disclosure of HIV status children and adolescents have been described. Each these places particular emphasis on role parents health care workers (HCWs) mitigate impact adolescent without exploring possible roles that other individuals might play in process disclosure. This article assesses perceptions living with (ALHIV) about done by parents, guardians, HCWs, peer educators supporters, accidentally or self-discovery, subsequent effects method their mental health....

Appropriately informing HIV-infected children of their diagnosis is a real challenge in sub-Saharan Africa. Until now, there no consensus on who ought to disclose and how disclose. This paper describes the model for HIV status disclosure which HIV-positive children/adolescents are informed about process conducted by young peers under healthcare worker (HCW) supervision hospital Kinshasa, Democratic Republic Congo. new take involving includes four stages that help trained peer supporters...

The performance of the WHO recommendations for pediatric antiretroviral treatment (ART) in resource poor settings is insufficiently documented routine care. We compared clinical and immunological criteria 366 children aged 0 to 12 years Kinshasa evaluated a simple computation estimate CD4 percent, based on count, total white blood cell count percentage lymphocytes. Kappa (κ) statistic was used evaluate eligibility linear regression determine trends lymphocyte (TLC). Agreement between (κ =...

Psychosocial support services are essential for effective HIV care, yet this area remains under-researched in sub-Saharan settings where the epidemic is most devastating. We explored relationships between social support, perceived stigma, and quality of life (QOL) HIV-positive adults participating a family-centered pediatric care treatment program Kinshasa, Democratic Republic Congo (DRC). Baseline interviews were conducted with 275 who caregivers or first-line relatives enrolled children....

Pulmonary emphysema and bronchiectasis in HIV seropositive patients has been described the presence of injection drug use, malnutrition, repeated opportunistic infections, such as Pneumocytis jirovici pneumonia Mycobacterium tuberculosis infection, linked to virus lung tissue. Given high burden pulmonary infections malnutrition among people living with resource poor settings, these individuals may be at increased risk developing emphysema, potentially reducing long term benefit...

Background/Objectives: Understanding the neurocognitive profile of children with sickle cell disease in Democratic Republic Congo is essential, as this condition can significantly affect their development. Our study aims to assess these children’s and developmental profiles identify related factors. Methods: We conducted a descriptive cross-sectional involving 287 children, aged 0 68 months, using Mullen Scales Early Learning Gensini Gavito Scale. also screened for maternal depression...

Background: To assess the mortality, immunological, hematological, and clinical outcomes of children initiating antiretroviral therapy (ART) during first 5 years (November 2004 – October 2009) a standardized HIV care treatment program at Kalembe-Lembe pediatric hospital in Kinshasa, DRC. Methods: Retrospective analysis routine data from cohort 603 HIV-infected children) 17 age ART initiation. Results: Children initiated median 6.4 [interquartile range 3.2–10.5] years. At initiation, 27.1%...

HIV status disclosure to children remains a challenge in sub-Saharan Africa. For sociocultural reasons, parents often delay with subsequent risks treatment compliance and the child’s psychological well-being. This article assesses effects of on second-line ART after first-line failure. We conducted retrospective study 52 HIV-positive at Kalembelembe Pediatric Hospital Kinshasa who were unaware their had failed respond ART. Before starting ART, some agreed disclosure. All followed before...

Objectives:The decision to initiate the antiretroviral therapy in HIV-infected children living poor countries is compromised by lack of resources. The objective this study identify simple clinical and biological markers other than CD4+ count viral load measurement that could help introduce treatment monitor patients.Methods:A cross sectional was conducted between January March 2005 Kinshasa, Democratic Republic Congo.Results:Eighty-four infected with HIV were recruited. In cohort,...

The visual dosing aid (VDA) was developed to facilitate calculations in response children's; growth and weight during antiretroviral treatment. theoretical accuracy of the VDA assessed using anthropometric data from 55 children receiving care USA 324 Democratic Republic Congo. dose similar WHO recommended dose. A potentially significant relative difference ≥20% occurred <3% for NVP, AZT d4T, but observed 20% 3TC, overdosing being more frequent. compared well with generic pediatric fixed...

<i>Objective</i>: description of a case neonatal hemoperitoneum due to splenic rupture after delivery by Kristeller obstetric maneuver in country with limited resources. <i>Methods</i>: This is clinical observation vaginal following maneuvers. The newborn presented on the 4th day life fever, anemic shock and abdominal distension for which ultrasound exploration showed hyperechoic fluid collection suggesting peritonitis. Urgent surgical revealed incoagulable blood laceration spleen two large...