A5028230573- Renal Diseases and Glomerulopathies
- Hemoglobinopathies and Related Disorders
- Chronic Kidney Disease and Diabetes
- Iron Metabolism and Disorders
- Trypanosoma species research and implications
- Dialysis and Renal Disease Management
- Chronic Lymphocytic Leukemia Research
- Lysosomal Storage Disorders Research
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Acute Lymphoblastic Leukemia research
- HIV/AIDS Research and Interventions
- Viral Infections and Outbreaks Research
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Central Venous Catheters and Hemodialysis
- Epigenetics and DNA Methylation
- Health, Environment, Cognitive Aging
- Urinary Tract Infections Management
- SARS-CoV-2 and COVID-19 Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Global Public Health Policies and Epidemiology
- Lymphatic Disorders and Treatments
- Acute Kidney Injury Research
- Viral Infections and Vectors
University of Kinshasa
2018-2024
KU Leuven
2021-2024
Apolipoprotein-L1 (
BackgroundBas-Congo virus (BASV), an emerging tibrovirus, was associated with outbreak of acute haemorrhagic fever in Mangala, Democratic Republic the Congo, 2009. In 2012, neutralising antibodies to BASV were detected lone survivor and one his close contacts. However, subsequent serological molecular surveys unsuccessful as neither nor its RNA detected. this study, we determined seroprevalence infection Mangala 13 years after initial outbreak.MethodsWe conducted a population-based survey...
In the Democratic Republic of Congo (DRC), acute kidney injury (AKI) contributes to high rate child mortality owing conjunction poverty, deficiency qualified health-care providers in pediatric nephrology, and lack dialysis programs. We aimed describe recent experience first peritoneal (PD) program DRC. This is a retrospective cohort study on epidemiology, clinical features outcomes children admitted from January 2018 2019 at University Hospital Kinshasa for AKI treated with PD. PD started by...
Summary Clinical and genetic factors have been reported as influencing the development of sickle cell nephropathy (SCN). However, such data remain limited in paediatric population. In this cross‐sectional study, we enrolled 361 disease children from Democratic Republic Congo. Participants were genotyped for beta (β)‐globin gene, apolipoprotein L1 ( APOL1 ) risk variants, haem oxygenase‐1 HMOX1 GT‐dinucleotide repeats. As markers kidney damage, albuminuria, hyperfiltration decreased estimated...
Apolipoprotein L1 (APOL1) high-risk genotypes (HRG), G1 and G2, increase the risk of various non-diabetic kidney diseases in African population. To date, precise mechanisms by which APOL1 variants induce injury on podocytes other cells remain unclear. Trying to unravel these mechanisms, most studies have used animal or cell models created gene editing. We developed characterised conditionally immortalised human podocyte lines derived from urine a donor carrying HRG G2/G2. Following induction...
Purpose. An association between APOL1 risk genotypes (HRG) and hypertension has been reported in African Americans with chronic kidney diseases (CKD). However, such data from populations living a Human Trypanosomiasis (HAT) endemic area remain limited.This study assessed the high-risk among sub-Saharan T.b. gambiense area.
 Methodology. This cross-sectional enrolled 94 HAT-infected 144 non–infected participants Masimanimba, Democratic Republic of Congo, April 2019 to 2021. We evaluated...
Objective: this study assessed the frequency of Apolipoprotein-L1 high-risk genotypes in an African rural endemic area to Trypanosoma Brucei Gambiense, and evaluated their association with arterial hypertension according human trypanosomiasis infection status. Design method: The enrolled 94 trypanosomiasis-infected 144 non–infected participants Masimanimba, Democratic Republic Congo. genotype was presence two variants (G1G1, G2G2, or G1G2), low-risk 0 1 variant. Albuminuria...
Purpose. The relationship between APOL1 variants and cardiovascular disease remains controversial, thus, this study assessed the association high-risk genotypes left ventricular hypertrophy (LVH) among sub-Saharan African in T.b. gambiense endemic area. Methodology. We enrolled 238 subjects living region of Masimanimba, an area T.b.gambiense HAT. evaluated LVH on echocardiography status genes participants with or without genotype (HRG) was defined as presence two risk (G1/G1, G2/G2, G1/G2),...
Summary Glomerular hyperfiltration and albuminuria are frequent kidney abnormalities in children with sickle cell anaemia (SCA). However, little is known about their persistence African SCA children. This prospective study included 600 steady‐state aged 2–18 years from the Democratic Republic of Congo. Participants were genotyped for apolipoprotein L1 ( APOL1 ) risk variants (RVs) haem oxygenase‐1 HMOX1 GT‐dinucleotide repeats. Kidney defined as albuminuria, or decreased estimated...
Introduction: Apolipoprotein L1 (APOL1) risk variants (G1, G2) are known to enhance the protective ability against human African trypanosomiasis (HAT), in addition their role kidney and cardiovascular disease. The effects of these on trypanosome infection could differ regionally owing local adaptations host pathogen. This study explored APOL1 distribution HAT-infected non-infected populations from a rural Trypanosoma brucei gambiense (T. b. gambiense) endemic area Central Africa....
Context and objective. Urinary screening is a useful inexpensive tool for the early detection of urinary abnormalities in asymptomatic children. This might contribute to prevention chronic kidney disease later life. study aimed determine prevalence among school children town Kisantu. Methods. In cross-sectional study, apparently healthy aged 6 16 years were randomly recruited from 7 schools. Using dipstick test, recorded parameters interest proteinuria, hematuria, tract infection (defined as...
Abstract Background and Aims Chronic kidney disease (CKD) is associated with significant morbidity mortality among patients sickle cell anemia (SCA). Glomerular hyperfiltration (GHF) albuminuria are known as early manifestations of occurring in childhood can predict the progression to CKD these patients. Studies reported prevalence abnormalities SCA children using a single measure their association genetic risk factors, especially co-inheritance APOL1 variants (RVs). However, data on...
In 2015, the WHO adopted strategy "Treat all" which recommends initiation of ART in everyone living with HIV regardless number CD4 count. This has decreased mortality and increased survival infected individuals. However, limited information is available regarding burden kidney abnormalities children since implementation this strategy. Our study aimed to describe prevalence Democratic Republic Congo (DRC) 2015-WHO therapeutic recommendations.
Clinical and genetic factors have been reported to influence the development of sickle cell nephropathy (SCN). However, data on such association between these SCN remain limited in pediatric population, especially sub-Saharan Africa. Our study aimed to: (i) determine prevalence markers SCN, including albuminuria, glomerular hyperfiltration reduced kidney function a anemia (SCA) population control (HbAA) from Democratic Republic Congo (DRC); (ii) examine some clinical factors.