A5058552309- Neonatal and Maternal Infections
- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Bacterial biofilms and quorum sensing
- Animal Disease Management and Epidemiology
- Antibiotic Resistance in Bacteria
- Sepsis Diagnosis and Treatment
- Urinary Tract Infections Management
- Vibrio bacteria research studies
- Cell Image Analysis Techniques
- T-cell and Retrovirus Studies
- Global Maternal and Child Health
- Bacterial Identification and Susceptibility Testing
- Global Cancer Incidence and Screening
- Global Public Health Policies and Epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Maternal and Neonatal Healthcare
- 3D Printing in Biomedical Research
- Parasitic Infections and Diagnostics
- Family Support in Illness
- Rabies epidemiology and control
- Public Health and Nutrition
- Microbial Inactivation Methods
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
University of Oxford
2021-2024
Cardiff University
2021-2022
Ineos (United Kingdom)
2022
Aberystwyth University
2015
Moredun Research Institute
1994-2001
University of Manitoba
1996
Antimicrobial resistance in neonatal sepsis is rising, yet mechanisms of that often spread between species via mobile genetic elements, ultimately limiting treatments low- and middle-income countries (LMICs), are poorly characterized. The Burden Antibiotic Resistance Neonates from Developing Societies (BARNARDS) network was initiated to characterize the cause burden antimicrobial for seven LMICs Africa South Asia. A total 36,285 neonates were enrolled BARNARDS study November 2015 December...
BackgroundNeonatal sepsis is a primary cause of neonatal mortality and an urgent global health concern, especially within low-income middle-income countries (LMICs), where 99% occurs. The aims this study were to determine the incidence associations with all-cause in facility-born neonates LMICs.MethodsThe Burden Antibiotic Resistance Neonates from Developing Societies (BARNARDS) recruited mothers their into prospective observational cohort across 12 clinical sites Bangladesh, Ethiopia,...
Abstract Hospital surfaces can harbour bacterial pathogens, which may disseminate and cause nosocomial infections, contributing towards mortality in low- middle-income countries (LMICs). During the BARNARDS study, hospital from neonatal wards were sampled to assess degree of environmental surface patient care equipment colonisation by Gram-negative bacteria (GNB) carrying antibiotic resistance genes (ARGs). Here, we perform PCR screening for extended-spectrum β-lactamases ( bla CTX-M-15 )...
Sepsis is a major contributor to neonatal mortality, particularly in low-income and middle-income countries (LMICs). WHO advocates ampicillin-gentamicin as first-line therapy for the management of sepsis. In BARNARDS observational cohort study sepsis antimicrobial resistance LMICs, common pathogens were characterised via whole genome sequencing (WGS) profiles. this substudy BARNARDS, we aimed assess use efficacy empirical antibiotic therapies commonly used LMICs
Abstract Early development of the microbiome has been shown to affect general health and physical infant and, although some studies have undertaken in high-income countries, there are few from low- middle-income countries. As part BARNARDS study, we examined rectal microbiota 2,931 neonates (term used up 60 d) with clinical signs sepsis 15,217 mothers screening for bla CTX-M-15 , NDM KPC OXA-48 -like genes, which were detected 56.1%, 18.5%, 0% 4.1% neonates’ swabs 47.1%, 4.6%, 1.6% mothers’...
Newborn sepsis accounts for more than a third of neonatal deaths globally and one in five Ethiopia. The first-line treatment recommended by WHO is the combination gentamicin with ampicillin or benzylpenicillin. Gram-negative bacteria (GNB) are increasingly resistant to previously effective antibiotics.
In low- and middle-income countries (LMIC) Staphylococcus aureus is regarded as one of the leading bacterial causes neonatal sepsis, however there limited knowledge on species diversity antimicrobial resistance caused by Gram-positive bacteria (GPB).We characterised GPB isolates from blood cultures LMICs in Africa (Ethiopia, Nigeria, Rwanda, South Africa) South-Asia (Bangladesh Pakistan) between 2015-2017. We determined minimum inhibitory concentrations performed whole genome sequencing...
Sheep can be immunised against toxoplasma abortion with a live vaccine composed of S48 tachyzoites. In this study the immunity induced in sheep was examined 18 months after vaccination. Seventy-three were divided into three groups. Group 1 vaccinated and later, when they 90 days pregnant, 27 challenged orally Toxoplasma gondii oocysts. These ewes produced significantly more lambs, longer gestation period, than 34 unvaccinated, group 2. addition there less placental damage fewer lambs born...
In this article, the role of information, support, and communication in promoting adaptation to risk breast cancer is reported. These variables emerged from an in-depth study women at for because one or more their primary (first degree) relatives. Fifty-five with mothers, sisters, mother sister, another relative were interviews using semi-structured, tape-recorded interviews. After transcription, data analyzed qualitative analysis procedures. A three-phase process was uncovered, which...
In this study, a new rapid automated yeast cell counter was assessed. The (Aber Countstar) uses bright-field microscopy and dye-exclusion method. This study's aim to determine whether method could be effectively employed in an slide based assess viability compare with results from traditional radio-frequency impedance-based instrument Compact Lab Yeast Analyser). Excellent correlations were observed between methods. performed well over range of concentrations (R2 = 0.9913 correlation manual...
Experimentally induced toxoplasmosis in pregnant ewes was treated with a combination of sulphamezathine and pyrimethamine. Fifteen untreated gave birth to 14 live six dead lambs whereas all the 15 born 12 were viable. The placental lesions less severe, gestation period longer precolostral antibody titres Toxoplasma gondii lower, significantly, for ewes.
Background Performing accurate sample analyses during the culture of mammalian cells is vital in order to track number and viability present. This allows operators recognise when reagents may need be added maximise yield, harvest appropriately identify a targeted cell concentration has been reached. commonly performed via manual counts. Cell stains, such as Trypan blue are classically utilised for ‘dye exclusion’ assessment viability, whereby dead stained colour dye live remain colourless....