A5078767515- Salmonella and Campylobacter epidemiology
- earthquake and tectonic studies
- Viral gastroenteritis research and epidemiology
- Earthquake Detection and Analysis
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- High-pressure geophysics and materials
- Veterinary medicine and infectious diseases
- Seismic Waves and Analysis
- Yeasts and Rust Fungi Studies
- Animal Nutrition and Physiology
- Seismic Imaging and Inversion Techniques
- Vibrio bacteria research studies
- Seismology and Earthquake Studies
- Plant Pathogens and Fungal Diseases
- Streptococcal Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- Escherichia coli research studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Geological and Geophysical Studies
- Bacterial Genetics and Biotechnology
- Enterobacteriaceae and Cronobacter Research
- Antimicrobial Resistance in Staphylococcus
- Biosensors and Analytical Detection
- Gut microbiota and health
Central South University
2025
Iowa State University
2015-2024
University of Michigan
2023
King University
2019
Peking University
2019
Guangxi University
2017
Ames National Laboratory
2014-2017
Chinese Academy of Sciences
2004-2016
Institute of Microbiology
2004-2016
Southern Medical University
2015
IncX4 plasmids are associated with the dissemination of mcr-1 genes in Enterobacteriaceae. We screened among 2,470 isolates Enterobacteriaceae and determined positive isolates. Forty-three were observed to carry type plasmid, which 13 identified gene. Three representative mcr-1-positive selected for high-throughput sequencing. Comparative genomics showed that mcr-1-carrying exhibit remarkable similarity backbone, major distinction lies region containing mcr-1. The variable regions all fully...
The aim of the study was to investigate mode action (-)-α-pinene in terms its modulation antibiotic resistance Campylobacter jejuni. Broth microdilution and ethidium bromide accumulation assays were used evaluate antimicrobial activity, resistance, inhibition efflux. target efflux systems identified using an insertion mutagenesis approach, C. jejuni adaptation evaluated DNA microarrays. Knock-out mutants key up-regulated transcriptional regulators hspR hrcA constructed their roles several...
To identify and characterize a novel cfr variant that recently emerged confers multidrug resistance in Campylobacter , major foodborne pathogen.WGS was initially used to the (C) gene isolates its function further verified by cloning into an antibiotic-susceptible jejuni strain. Distribution of various determined PCR analysis. Genotyping (C)-positive strains done PFGE MLST.The is predicted encode protein shares 55.1% 54.9% identity with Cfr Cfr(B), respectively. located on conjugative plasmid...
Streptococcus suis is a previously neglected, newly emerging multidrug-resistant zoonotic pathogen. Mobile genetic elements (MGEs) play key role in intra- and interspecies horizontal transfer of antimicrobial resistance (AMR) determinants. Although, previous studies showed the presence several MGEs, comprehensive analysis AMR-associated mobilome as well their interaction evolution has not been performed. In this study, we presented insertion hotspots S. suis. Integrative conjugative (ICEs),...
Abstract Bacille Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis currently used as a vaccine against tuberculosis. Global distribution and propagation BCG has contributed to the in vitro evolution thought partially account for different outcomes trials. Previous efforts by several molecular techniques effectively identified large sequence polymorphisms among daughter strains, but lacked resolution identify smaller changes. In this study, we have NimbleGen tiling array...
Background Leptospira interrogans is the major causative agent of leptospirosis. Phagocytosis plays important roles in innate immune responses to L. infection, and can evade killing phagocytes. However, little known about adaptation during this process. Methodology/Principal Findings To better understand interaction pathogenic immunity, we employed microarray comparative genomics analyzing macrophage-derived cells. During process, altered expressions many genes involved carbohydrate lipid...
Weaning is one of the most stressful challenges in pig's life, which contributes to dysfunctions intestinal and immune system, disrupts gut microbial ecosystem, therefore compromises growth performance health piglets. To mitigate negative impact stress on early-weaned piglets, effective measures are needed promote health. Toward this end, we tamed a Saccharomyces cerevisiae strain developed probiotic Duan-Nai-An, yeast culture S. egg white. In study, tested Duan-Nai-An piglets analyzed its...
Abstract Antibiotic resistance, particularly to fluoroquinolones and macrolides, in the major foodborne pathogen Campylobacter is considered a serious threat public health. Although ruminant animals serve as significant reservoir for , limited information available on antibiotic-resistant of bovine origin. Here, we analyzed antimicrobial susceptibilities 320 C. jejuni 115 coli isolates obtained from feedlot cattle farms multiple states U.S. The results indicate that fluoroquinolone...
Health care-associated infections, also known as nosocomial are the most frequent adverse events in health care delivery worldwide, causing high rates of morbidity and mortality costs. Pseudomonas aeruginosa is one leading bacterial species infections. Carbapenems effective antimicrobial agents for treatment its severe
Prophages play important roles in the transduction of various functional traits, including virulence factors, but remain debatable harboring and transmitting antimicrobial resistance genes (ARGs). Herein we characterize a prevalent family prophages Streptococcus, designated SMphages, which harbor twenty-five ARGs that collectively confer to ten classes, vanG-type vancomycin locus oxazolidinone gene optrA. SMphages integrate into four chromosome attachment sites by utilizing three types...
Research Article| May 01, 2011 Developing a Prototype Earthquake Early Warning System in the Beijing Capital Region Hanshu Peng; Peng Institute of Geophysics China Administration 100081 penghs@cea-igp.ac.cn (H. P.) 1Institute Geophysics, Administration, Search for other works by this author on: GSW Google Scholar Zhongliang Wu; Wu Yih-Min 2Department Geosciences, National Taiwan University, Taipei Shuming Yu; Yu 3Department Monitoring and Prediction, Dongning Zhang; Zhang Wenhui Huang...
We describe the setup of testing regions for China Earthquake Forecast Testing Center and provide preliminary forecast results in scope Collaboratory Study Predictability (CSEP) project. investigate spatiotemporal variations completeness magnitude M c by using frequency‐magnitude distribution Networks (CENC) catalog. find three periods significantly different histories: (I) 1 January 1970–30 September 2001, (II) October 2001–30 2008, (III) 2008–31 August 2011. mapping provides median values...
Significance Identification of specific genetic changes responsible for pathogen emergence and evolution is critical disease prevention control. By using a powerful high throughput approach (directed genome evolution), we identified the point mutations in major outer membrane protein that drive hypervirulence an emergent Campylobacter jejuni clone, which causes abortion ruminants foodborne outbreaks humans. This finding reveals virulence factor potential target control , important zoonotic...
ABSTRACT The recent emergence of a transferable colistin resistance mechanism, MCR-1, has gained global attention because its threat to clinical treatment infections caused by multidrug-resistant Gram-negative bacteria. However, the possible transmission route mcr-1 among Enterobacteriaceae species in settings is largely unknown. Here, we present comprehensive genomic analysis Escherichia coli isolates collected hospital Hangzhou, China. We found that -carrying from and feces inpatients...
Polymyxin acts as an ultimate line of refuge against the severe infections by multidrug-resistant Gram-negative pathogens. This conventional idea is challenged dramatically recent discovery mobile colistin resistance gene (mcr-1) prevalent in food animals and human beings worldwide. More importantly, mcr-1 was found to be co-localized with other antibiotic genes, raising possibility that super-bugs pan-drug are emerging. However, little reported on genomes mcr-1-positive bacterial host...
ABSTRACT Campylobacter jejuni clone SA is the major cause of sheep abortion and contributes significantly to foodborne illnesses in United States. Clone hypervirulent because its distinct ability produce systemic infection predominant role clinical abortion. Despite importance SA, little known about distribution epidemiological features cattle. Here we describe a prospective study on C. prevalence 35 feedlots 5 different states States retrospective analysis isolates collected by National...
Abstract Campylobacter enterocolitis may lead to post-infection irritable bowel syndrome (PI-IBS) and while some C. jejuni strains are more likely than others cause human disease, genomic virulence characteristics promoting PI-IBS development remain uncharacterized. We combined pangenome-wide association studies phenotypic assays compare isolates from patients who developed with those did not. show that variation in bacterial stress response ( Cj0145_phoX ), adhesion protein Cj0628_CapA core...
Proliferative hepatocellular carcinoma (HCC) is an aggressive phenotype associated with unfavorable clinical outcomes. Predicting the preoperative subtype of HCC can aid in development individualized treatment. We retrospectively recruited 180 patients who underwent hepatic resection and established a CT-based radiomics model for predicting proliferative HCCs. The evaluation tumor response to transarterial chemoembolization therapy progression-free survival (PFS) according was further...