A5008767565- Toxoplasma gondii Research Studies
- Parasitic Infections and Diagnostics
- Herpesvirus Infections and Treatments
- Animal Nutrition and Physiology
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Microbial infections and disease research
- Coccidia and coccidiosis research
- Viral Infections and Vectors
- Bird parasitology and diseases
- Sex work and related issues
- Virology and Viral Diseases
- Escherichia coli research studies
- Livestock and Poultry Management
- Power System Reliability and Maintenance
- Power Line Communications and Noise
- Advanced Optical Network Technologies
- Helminth infection and control
- Veterinary medicine and infectious diseases
- Vector-borne infectious diseases
- Insects and Parasite Interactions
- Parasitic infections in humans and animals
- Viral gastroenteritis research and epidemiology
- Cytomegalovirus and herpesvirus research
- Optical Network Technologies
Moredun Research Institute
2014-2024
Ross University School of Veterinary Medicine
2014-2019
University College Dublin
2012-2014
University of Bristol
2007-2009
Dublin City University
2008-2009
Modulation Therapeutics (United States)
2009
Trinity College Dublin
2004-2007
Swedish Veterinary Agency
2003
Williams (United States)
2003
Core Competence
1987-1988
The tenth session of the Conference Parties to Convention on Biological Diversity successfully adopted ‘Nagoya Protocol Access Genetic Resources and Fair Equitable Sharing Benefits Arising from their Utilization Diversity’ in October 2010. This article identifies main challenges final negotiations explains framework for access benefit‐sharing established by both genetic resources traditional knowledge associated with resources. It also describes more detail Protocol's economic, temporal...
We have previously shown that the integral membrane protein CD317 has both a conventional transmembrane domain near its N-terminus and C-terminal glycosyl-phosphatidylinositol (GPI) anchor. With possible exception of minor topological variant prion protein, there remain no other convincing examples mammalian with such topology. is localised to cholesterol-rich lipid microdomains ('lipid rafts') in plasma internalised from cell surface for delivery juxta-nuclear compartment (most probably...
CD317/tetherin is a lipid raft–associated integral membrane protein with novel topology. It has short N-terminal cytosolic domain, conventional transmembrane and C-terminal glycosyl-phosphatidylinositol anchor. We now show that CD317 expressed at the apical surface of polarized epithelial cells, where it interacts indirectly underlying actin cytoskeleton. linked to network via proteins RICH2, EBP50, ezrin. Knocking down expression either or RICH2 gives rise same phenotype: loss concomitant...
Fasciola hepatica is a helminth pathogen that drives Th2/Treg immune responses in its mammalian host. The parasite releases large number of molecules are critical to inducing this type response. Here we have selected recombinant forms two major F. secreted molecules, the protease cathepsin L (rFhCL1) and an antioxidant, sigma class glutathione transferase (rFhGST-si), examine their interactions with dendritic cells (DCs). Despite enzymatic functional differences between these both induced...
Parasitic worms and molecules derived from them have powerful anti-inflammatory properties are shown to therapeutic effects on inflammatory diseases. The helminth Fasciola hepatica has been reported suppress antigen-specific Th1 responses in concurrent bacterial infections, thus demonstrating its ability vivo. Here, F. tegumental antigen (Teg) was significantly serum levels of gamma interferon (IFN-gamma) interleukin-12p70 (IL-12p70) a model septic shock. Since dendritic cells (DCs) good...
A ring trial among five European laboratories was organized to reach consistency in microsatellite (MS) typing of the zoonotic parasite Toxoplasma gondii. Three sample sets were circulated and analyzed by each laboratory following a previously published method that is based on fragment length polymorphism 15 MS markers. The first set compared results general focused effects DNA concentration; second polymorphic fingerprinting markers can differentiate T. gondii strains within same archetypal...
Toxocara canis is a parasitic nematode that infects canines worldwide, and as consequence of the widespread environmental dissemination its ova in host faeces, other abnormal hosts including mice humans are exposed to infection. In such or paratenic hosts, immature third-stage larvae undergo somatic migration through organs body but fail reach maturity adult worms intestine. The presence migrating contributes pathology dependent upon intensity infection location larvae. A phenomenon...
Toxoplasma gondii is a globally important zoonotic parasite ranked as one of the most significant causes disease burden among major foodborne pathogens. Consumption undercooked meat well-known risk factor for infection so aim this study was to investigate presence T. in samples from retail outlets Scotland. In Sampling Period 1, 300 (39 beef, 21 chicken, 87 lamb, 71 pork and 82 venison) were purchased butchers', farmers' markets, farm shops supermarkets, 2, 67 pure venison only supermarkets....
Abstract Livestock abortion is an important cause of productivity losses worldwide and many infectious causes are zoonotic pathogens that impact on human health. Little known about the relative importance livestock in Africa, including subsistence farming communities critically dependent for food, income, wellbeing. We conducted a prospective cohort study abortion, supported by cross-sectional serosurveillance, to determine aetiologies abortions Tanzania. This approach generated several...
Toxoplasma gondii is a protozoan parasite capable of infecting all warm-blooded animals including livestock. In these animals, the forms cysts in tissues which may pose risk to public health if infected meat consumed undercooked or raw. Little known epidemiology T. Caribbean; therefore, aim this study was determine exposure small ruminants from four Caribbean island nations. Sera 305 sheep and 442 goats Dominica, Grenada, Montserrat St. Kitts Nevis were examined for antibodies using an house...
Toxoplasma gondii is a zoonotic parasite of global importance. The outcome infection in humans can depend on number factors including the infecting stage parasite, inoculating dose and virulence strain. Molecular epidemiological studies have demonstrated an abundance atypical strains T. South America, many which been associated with more severe sequelae infection. aim this study was to compare isolated Caribbean virulent Brazilian strain avirulent European One hundred twenty Swiss CD-1 mice...
Toxoplasma gondii is a ubiquitous protozoan parasite capable of infecting all warm-blooded animals including livestock. In these animals, the forms cysts in tissues which may pose risk to public health if infected meat consumed undercooked or raw. The aim this study was determine exposure livestock T. St. Kitts and Nevis. Sera and/or heart tissue juice were collected from pigs (n = 124), sheep 116) goats 66) at Abattoir. screened for reactive antibodies using an in-house ELISA. Heart DNA...
This study aimed to determine the prevalence of Babesia species DNA in lung exudate samples collected from red foxes (Vulpes vulpes) across Great Britain. are small piroplasmid parasites which mainly transmitted through bite infected ticks family Ixodidae. can cause potentially fatal disease a wide-range mammalian including humans, dogs and cattle, making them significant economic importance both medical veterinary fields. was extracted 316 foxes. A semi-nested PCR used initially screen...
CURRENT interest in Newcastle disease makes the presentation of special case histories desirable. This is particularly true when these substantiate and add to observations other investigations as effects on laying birds. Beach (1943) showed that pneumoencephalitis caused a sudden drastic drop egg production mortality about 5.0 percent. Lorenz Newlon (1944) observed abnormal quality manifested by bubbly eggs, decreased albumen height, shells. The data herein presented adds evidence effect an...
The bacterium Coxiella burnetii can cause the disease Q-fever in a wide range of animal hosts. Ruminants, including sheep, are thought to play pivotal role transmission C. humans; however, only existing livestock vaccine, namely, Coxevac® (Ceva Animal Health Ltd., Libourne, France), killed bacterin vaccine based on phase I strain Nine-Mile, is approved for use goats and cattle. In this study, pregnant ewe challenge model was used determine protective effects an experimental II against...
Toxocara canis, the parasitic roundworm of dogs, can infect a number paratenic hosts, such as mice and humans, due to widespread dissemination its ova in environment. In these larvae have been shown exhibit predilection for central nervous system, resulting an increasing parasites migrating brain infection progresses. initial experiment, we investigated differential involvement T. canis 7 strains inbred mice, chose 2 strains, susceptible (BALB/c) resistant (NIH) cerebral infection. second...
Neospora caninum is a protozoan intracellular parasite of animals with global distribution. Dogs act as definitive hosts, infection in cattle leading to reproductive losses. Neosporosis can be major source income loss for livestock keepers, but its impacts sub-Saharan Africa are mostly unknown. This study aimed estimate the seroprevalence and identify risk factors N. northern Tanzania, link herd-level exposure Serum samples from 3,015 were collected 380 households 20 villages between...